prompt
string | hit
int64 | screen_id
int64 | crispr_strategy
string | gene
string | phenotype
string | cell_type
string | gene_context
string |
|---|---|---|---|---|---|---|---|
Does Knockout of Mrpl20 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,838
|
Knockout
|
Mrpl20
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Mrpl20 (mitochondrial ribosomal protein L20)
Type: protein-coding
Summary: Predicted to be a structural constituent of ribosome. Predicted to be involved in mitochondrial translation. Predicted to act upstream of or within translation. Located in mitochondrion. Is expressed in several structures, including extraembryonic component; ganglia; genitourinary system; jaw; and musculoskeletal system. Orthologous to human MRPL20 (mitochondrial ribosomal protein L20). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: mitochondrial translation, translation; MF: rRNA binding, structural constituent of ribosome; CC: mitochondrial inner membrane, mitochondrial large ribosomal subunit, mitochondrial ribosome, mitochondrion, ribonucleoprotein complex, ribosome
Pathways: Metabolism of proteins, Mitochondrial ribosome-associated quality control, Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation termination, Ribosome - Mus musculus (mouse), Translation
UniProt: Q9CQL4
Entrez ID: 66448
|
Does Knockout of Ddx6 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 578
|
Knockout
|
Ddx6
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Ddx6 (DEAD-box helicase 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: P-body assembly, miRNA-mediated gene silencing by inhibition of translation, negative regulation of neuron differentiation, negative regulation of translation, spermatid differentiation, spermatogenesis, stem cell population maintenance, stress granule assembly, viral RNA genome packaging; MF: ATP binding, ATP hydrolysis activity, RNA binding, RNA helicase activity, helicase activity, hydrolase activity, mRNA binding, nucleic acid binding, nucleotide binding, protein domain specific binding; CC: P-body, RISC complex, adherens junction, chromatoid body, concave side of sperm head, cytoplasm, cytoplasmic ribonucleoprotein granule, cytoplasmic stress granule, cytosol, heterochromatin, nucleus, outer dense fiber, perinuclear region of cytoplasm, plasma membrane, sperm annulus
Pathways: Deadenylation-dependent mRNA decay, Metabolism of RNA, RNA degradation - Mus musculus (mouse), mRNA decay by 5' to 3' exoribonuclease
UniProt: P54823
Entrez ID: 13209
|
Does Knockout of Adh4 in Pancreatic Cancer Cell Line causally result in response to chemicals?
| 0
| 2,359
|
Knockout
|
Adh4
|
response to chemicals
|
Pancreatic Cancer Cell Line
|
Gene: Adh4 (alcohol dehydrogenase 4 (class II), pi polypeptide)
Type: protein-coding
Summary: Enables NADPH:quinone reductase activity; alcohol dehydrogenase (NAD+) activity; and aldose reductase (NADPH) activity. Involved in fatty acid omega-oxidation. Acts upstream of or within several processes, including alcohol catabolic process; ethanol metabolic process; and quinone metabolic process. Predicted to be located in nucleoplasm. Predicted to be active in cytosol. Is expressed in several structures, including adrenal cortex; genitourinary system; integumental system; limb; and nervous system. Human ortholog(s) of this gene implicated in alcohol dependence. Orthologous to human ADH4 (alcohol dehydrogenase 4 (class II), pi polypeptide). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: alcohol catabolic process, alcohol metabolic process, aldehyde metabolic process, ethanol metabolic process, fatty acid omega-oxidation, formaldehyde catabolic process, lipid metabolic process, quinone metabolic process, retinoid metabolic process, retinol metabolic process, small molecule catabolic process; MF: NAD binding, S-(hydroxymethyl)glutathione dehydrogenase [NAD(P)+] activity, alcohol dehydrogenase (NAD+) activity, aldose reductase (NADPH) activity, all-trans retinal binding, all-trans-retinol dehydrogenase (NAD+) activity, benzaldehyde dehydrogenase (NAD+) activity, metal ion binding, oxidoreductase activity, quinone reductase (NADPH) activity, retinol binding, zinc ion binding; CC: cytoplasm, cytosol, nucleoplasm
Pathways: Alcoholic liver disease - Mus musculus (mouse), Biological oxidations, Drug metabolism - cytochrome P450 - Mus musculus (mouse), Ethanol oxidation, Fatty acid degradation - Mus musculus (mouse), Glycolysis / Gluconeogenesis - Mus musculus (mouse), Metabolism, Metabolism of xenobiotics by cytochrome P450 - Mus musculus (mouse), Phase I - Functionalization of compounds, Pyruvate metabolism - Mus musculus (mouse), RA biosynthesis pathway, Retinol metabolism - Mus musculus (mouse), Signal Transduction, Signaling by Nuclear Receptors, Signaling by Retinoic Acid, Tyrosine metabolism - Mus musculus (mouse), ethanol degradation II (cytosol), phenylalanine degradation III
UniProt: Q9QYY9
Entrez ID: 26876
|
Does Knockout of Ccr6 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 2,308
|
Knockout
|
Ccr6
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Ccr6 (C-C motif chemokine receptor 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DN2 thymocyte differentiation, DN3 thymocyte differentiation, G protein-coupled receptor signaling pathway, T cell migration, calcium-mediated signaling, cell chemotaxis, chemokine-mediated signaling pathway, chemotaxis, immune response, isotype switching to IgA isotypes, leukocyte migration involved in inflammatory response, lymphocyte migration, positive regulation of cytosolic calcium ion concentration, positive regulation of dendritic cell chemotaxis, positive regulation of epithelial cell migration, positive regulation of flagellated sperm motility involved in capacitation, regulation of T cell migration, regulation of T-helper 17 cell differentiation, signal transduction, thymocyte migration; MF: C-C chemokine binding, C-C chemokine receptor activity, G protein-coupled receptor activity, chemokine receptor activity, protein binding; CC: cell surface, external side of plasma membrane, membrane, plasma membrane, sperm flagellum, sperm midpiece, sperm plasma membrane, sperm principal piece
Pathways: Antimicrobial peptides, Beta defensins, Chemokine receptors bind chemokines, Chemokine signaling pathway - Mus musculus (mouse), Class A/1 (Rhodopsin-like receptors), Cytokine-cytokine receptor interaction - Mus musculus (mouse), Defensins, G alpha (i) signalling events, GPCR downstream signalling, GPCR ligand binding, Immune System, Innate Immune System, Peptide ligand-binding receptors, Signal Transduction, Signaling by GPCR, Viral protein interaction with cytokine and cytokine receptor - Mus musculus (mouse)
UniProt: O54689
Entrez ID: 12458
|
Does Knockout of Fam162b in macrophage causally result in phagocytosis?
| 0
| 1,888
|
Knockout
|
Fam162b
|
phagocytosis
|
macrophage
|
Gene: Fam162b (family with sequence similarity 162, member B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cellular_component, membrane
Pathways:
UniProt: Q9CX19
Entrez ID: 77296
|
Does Knockout of Knop1 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,280
|
Knockout
|
Knop1
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Knop1 (lysine rich nucleolar protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: nucleolus, nucleus
Pathways:
UniProt: Q9Z2Q2
Entrez ID: 66356
|
Does Knockout of Pcdha2 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 579
|
Knockout
|
Pcdha2
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Pcdha2 (protocadherin alpha 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell adhesion, homophilic cell adhesion via plasma membrane adhesion molecules; MF: calcium ion binding, cell adhesion molecule binding, molecular_function; CC: endoplasmic reticulum, membrane, nucleus, plasma membrane
Pathways:
UniProt: Q05C01, Q91Y17, B9EJ92
Entrez ID: 353234
|
Does Knockout of Oas1g in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,277
|
Knockout
|
Oas1g
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Oas1g (2'-5' oligoadenylate synthetase 1G)
Type: protein-coding
Summary: This gene encodes a member of the oligoadenylate synthetase family of proteins. This gene and several other family members are present in a gene cluster on chromosome 5. These proteins are believed to function in antiviral immunity through binding to viral dsRNA and subsequent synthesis of 2'-5'-oligoadenylates. The expression of this gene has been shown to be induced by interferon. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Nov 2014].
Gene Ontology: BP: antiviral innate immune response, cellular response to exogenous dsRNA, cellular response to interferon-alpha, cellular response to interferon-beta, defense response to bacterium, defense response to virus, glucose homeostasis, glucose metabolic process, immune system process, innate immune response, interleukin-27-mediated signaling pathway, negative regulation of IP-10 production, negative regulation of chemokine (C-X-C motif) ligand 2 production, negative regulation of type I interferon-mediated signaling pathway, negative regulation of viral genome replication, positive regulation of cellular respiration, positive regulation of interferon-beta production, positive regulation of monocyte chemotactic protein-1 production, positive regulation of tumor necrosis factor production, protein complex oligomerization, response to virus, surfactant homeostasis, toll-like receptor 3 signaling pathway, toll-like receptor 4 signaling pathway, type I interferon-mediated signaling pathway; MF: 2'-5'-oligoadenylate synthetase activity, RNA binding, double-stranded RNA binding, nucleotidyltransferase activity; CC: cytoplasm, cytosol, membrane, mitochondrion, nucleoplasm, nucleus, ribosome
Pathways: Coronavirus disease - COVID-19 - Mus musculus (mouse), Epstein-Barr virus infection - Mus musculus (mouse), Hepatitis C - Mus musculus (mouse), Herpes simplex virus 1 infection - Mus musculus (mouse), Influenza A - Mus musculus (mouse), Measles - Mus musculus (mouse), NOD-like receptor signaling pathway - Mus musculus (mouse)
UniProt: Q05BJ7, Q8K469
Entrez ID: 23960
|
Does Knockout of Tmem200a in pro-B-lymphocyte causally result in response to chemicals?
| 0
| 1,720
|
Knockout
|
Tmem200a
|
response to chemicals
|
pro-B-lymphocyte
|
Gene: Tmem200a (transmembrane protein 200A)
Type: protein-coding
Summary: Predicted to be located in membrane. Orthologous to human TMEM200A (transmembrane protein 200A). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: CC: cellular_component, membrane
Pathways:
UniProt: Q8C817
Entrez ID: 77220
|
Does Knockout of Gja8 in breast epithelium causally result in cell cycle progression?
| 0
| 1,470
|
Knockout
|
Gja8
|
cell cycle progression
|
breast epithelium
|
Gene: Gja8 (gap junction protein, alpha 8)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: camera-type eye development, cell communication, cell-cell signaling, gap junction-mediated intercellular transport, lens development in camera-type eye, regulation of granulocyte macrophage colony-stimulating factor production, transmembrane transport; MF: gap junction channel activity, identical protein binding; CC: anchoring junction, connexin complex, gap junction, membrane, plasma membrane
Pathways: Gap junction assembly, Gap junction trafficking, Gap junction trafficking and regulation, Membrane Trafficking, Vesicle-mediated transport
UniProt: P28236
Entrez ID: 14616
|
Does Knockout of Pgr in Melanoma Cell Line causally result in protein/peptide accumulation?
| 0
| 1,839
|
Knockout
|
Pgr
|
protein/peptide accumulation
|
Melanoma Cell Line
|
Gene: Pgr (progesterone receptor)
Type: protein-coding
Summary: This gene encodes a member of the steroid receptor superfamily. The encoded protein mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with the establishment and maintenance of pregnancy. [provided by RefSeq, Sep 2015].
Gene Ontology: BP: epithelial cell maturation, female gonad development, female mating behavior, glandular epithelial cell maturation, lung alveolus development, maintenance of protein location in nucleus, mammary gland development, negative regulation of apoptotic process, negative regulation of gene expression, negative regulation of granulosa cell apoptotic process, nuclear receptor-mediated steroid hormone signaling pathway, ovulation cycle process, ovulation from ovarian follicle, paracrine signaling, positive regulation of DNA-templated transcription, positive regulation of cell population proliferation, positive regulation of smooth muscle cell migration, positive regulation of transcription by RNA polymerase II, progesterone receptor signaling pathway, regulation of DNA-templated transcription, regulation of epithelial cell proliferation, regulation of transcription by RNA polymerase II, response to cocaine, steroid hormone receptor signaling pathway, tertiary branching involved in mammary gland duct morphogenesis; MF: ATPase binding, DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, RNA polymerase II cis-regulatory region sequence-specific DNA binding, enzyme binding, estrogen response element binding, hormone binding, identical protein binding, lipid binding, metal ion binding, nuclear receptor activity, nuclear steroid receptor activity, protein binding, sequence-specific DNA binding, signaling receptor binding, steroid binding, transcription cis-regulatory region binding, transcription coactivator binding, zinc ion binding; CC: axon, axon terminus, chromatin, cytoplasm, dendrite, dendritic spine, nucleus, perikaryon, plasma membrane
Pathways: Breast cancer - Mus musculus (mouse), Cellular responses to stimuli, Cellular responses to stress, Chemical carcinogenesis - receptor activation - Mus musculus (mouse), ESR-mediated signaling, Estrogen signaling pathway - Mus musculus (mouse), Estrogen-dependent gene expression, Gene expression (Transcription), Generic Transcription Pathway, HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand, Metabolism of proteins, Nuclear Receptor transcription pathway, Oocyte meiosis - Mus musculus (mouse), Post-translational protein modification, Progesterone-mediated oocyte maturation - Mus musculus (mouse), RNA Polymerase II Transcription, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of intracellular receptors, Signal Transduction, Signaling by Nuclear Receptors
UniProt: Q00175
Entrez ID: 18667
|
Does Knockout of Tcstv3 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 2,403
|
Knockout
|
Tcstv3
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Tcstv3 (2 cell stage variable group member 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: O70518
Entrez ID: 236219
|
Does Knockout of Clec4a2 in Mouse Embryonic Stem Cell causally result in protein/peptide accumulation?
| 0
| 1,077
|
Knockout
|
Clec4a2
|
protein/peptide accumulation
|
Mouse Embryonic Stem Cell
|
Gene: Clec4a2 (C-type lectin domain family 4, member a2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: CD8-positive, alpha-beta T cell activation, adaptive immune response, antifungal innate immune response, antigen processing and presentation of exogenous peptide antigen via MHC class I, immune system process, innate immune response, negative regulation of cytokine production, negative regulation of tumor necrosis factor production, plasmacytoid dendritic cell antigen processing and presentation; MF: D-mannose binding, calcium ion binding, carbohydrate binding, metal ion binding, pattern recognition receptor activity; CC: external side of plasma membrane, membrane, plasma membrane
Pathways:
UniProt: Q9QZ15
Entrez ID: 26888
|
Does Knockout of Tcf21 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,271
|
Knockout
|
Tcf21
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Tcf21 (transcription factor 21)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Sertoli cell differentiation, animal organ morphogenesis, branching involved in ureteric bud morphogenesis, branchiomeric skeletal muscle development, bronchiole development, developmental process, diaphragm development, embryonic digestive tract morphogenesis, epithelial cell differentiation, gland development, glomerulus development, kidney development, lung alveolus development, lung morphogenesis, lung vasculature development, metanephric glomerular capillary formation, metanephric mesenchymal cell differentiation, morphogenesis of a branching structure, muscle structure development, negative regulation of androgen receptor signaling pathway, negative regulation of transcription by RNA polymerase II, positive regulation of transcription by RNA polymerase II, regulation of transcription by RNA polymerase II, reproductive structure development, respiratory system development, roof of mouth development, sex determination, sex differentiation, spleen development, ureteric bud development, vasculature development; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, E-box binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, bHLH transcription factor binding, histone deacetylase binding, nuclear androgen receptor binding, protein binding, protein dimerization activity, sequence-specific double-stranded DNA binding; CC: nucleoplasm, nucleus, transcription regulator complex
Pathways:
UniProt: O35437
Entrez ID: 21412
|
Does Knockout of Car6 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,285
|
Knockout
|
Car6
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Car6 (carbonic anhydrase 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: detection of chemical stimulus involved in sensory perception of bitter taste; MF: carbonate dehydratase activity, lyase activity, metal ion binding, zinc ion binding; CC: cytoplasm, cytosol, extracellular region, extracellular space
Pathways: Metabolism, Nitrogen metabolism - Mus musculus (mouse), Reversible hydration of carbon dioxide
UniProt: P18761
Entrez ID: 12353
|
Does Knockout of Bckdk in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,287
|
Knockout
|
Bckdk
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Bckdk (branched chain ketoacid dehydrogenase kinase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: L-isoleucine catabolic process, L-leucine catabolic process, L-valine catabolic process, branched-chain amino acid catabolic process, lipid biosynthetic process, regulation of glucose metabolic process, regulation of pyruvate decarboxylation to acetyl-CoA, spermatogenesis; MF: ATP binding, [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase activity, catalytic activity, acting on a protein, kinase activity, metal ion binding, nucleotide binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, protein serine/threonine phosphatase activity, pyruvate dehydrogenase (acetyl-transferring) kinase activity, transferase activity, transferase activity, transferring phosphorus-containing groups; CC: mitochondrial matrix, mitochondrion, oxoglutarate dehydrogenase complex
Pathways: Branched-chain amino acid catabolism, Metabolism, Metabolism of amino acids and derivatives
UniProt: O55028
Entrez ID: 12041
|
Does Knockout of Car3 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,259
|
Knockout
|
Car3
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Car3 (carbonic anhydrase 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to hypoxia, cellular response to insulin stimulus, cellular response to leptin stimulus, liver regeneration, negative regulation of apoptotic process, negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide, negative regulation of reactive oxygen species biosynthetic process, positive regulation of cell population proliferation, response to alcohol, response to bacterium, response to ethanol, response to lipid, response to oxidative stress, skeletal muscle contraction; MF: carbonate dehydratase activity, lyase activity, metal ion binding, nickel cation binding, phosphatase activity, zinc ion binding; CC: cytoplasm, cytosol, nucleus, sarcomere
Pathways: Metabolism, Nitrogen metabolism - Mus musculus (mouse), Reversible hydration of carbon dioxide
UniProt: P16015
Entrez ID: 12350
|
Does Knockout of Tomm6 in Regulatory T cell causally result in cell proliferation?
| 0
| 2,127
|
Knockout
|
Tomm6
|
cell proliferation
|
Regulatory T cell
|
Gene: Tomm6 (translocase of outer mitochondrial membrane 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: membrane, mitochondrial outer membrane, mitochondrial outer membrane translocase complex, mitochondrion
Pathways: Autophagy, Macroautophagy, Mitophagy, PINK1-PRKN Mediated Mitophagy, Selective autophagy
UniProt: Q9CQN3
Entrez ID: 66119
|
Does Knockout of Fip1l1 in Microglial Cell Line causally result in response to virus?
| 0
| 2,429
|
Knockout
|
Fip1l1
|
response to virus
|
Microglial Cell Line
|
Gene: Fip1l1 (factor interacting with PAPOLA and CPSF1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mRNA processing, regulation of mRNA 3'-end processing; MF: RNA binding, enzyme regulator activity, protein binding; CC: mRNA cleavage and polyadenylation specificity factor complex, nucleoplasm, nucleus
Pathways: Gene expression (Transcription), Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, Processing of Capped Intronless Pre-mRNA, Processing of Intronless Pre-mRNAs, RNA Polymerase II Transcription, RNA Polymerase II Transcription Termination, Transport of Mature Transcript to Cytoplasm, Transport of Mature mRNA Derived from an Intronless Transcript, Transport of Mature mRNAs Derived from Intronless Transcripts, mRNA 3'-end processing, mRNA surveillance pathway - Mus musculus (mouse)
UniProt: Q9D824
Entrez ID: 66899
|
Does Knockout of Plcl2 in Immortal mouse chromaffin cells causally result in cell viability?
| 0
| 2,469
|
Knockout
|
Plcl2
|
cell viability
|
Immortal mouse chromaffin cells
|
Gene: Plcl2 (phospholipase C-like 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: B cell proliferation involved in immune response, B-1a B cell differentiation, gamma-aminobutyric acid signaling pathway, intracellular signal transduction, lipid metabolic process, negative regulation of B cell receptor signaling pathway, negative regulation of cold-induced thermogenesis, phosphatidylinositol metabolic process, phosphatidylinositol-mediated signaling, regulation of synaptic transmission, GABAergic, release of sequestered calcium ion into cytosol, signal transduction; MF: GABA receptor binding, inositol 1,4,5 trisphosphate binding, phosphatidylinositol-4,5-bisphosphate phospholipase C activity, phosphoric diester hydrolase activity
Pathways:
UniProt: Q8K394
Entrez ID: 224860
|
Does Knockout of Best2 in Colonic Cancer Cell Line causally result in tumorigenicity?
| 0
| 2,181
|
Knockout
|
Best2
|
tumorigenicity
|
Colonic Cancer Cell Line
|
Gene: Best2 (bestrophin 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: bicarbonate transport, chloride transmembrane transport, chloride transport, membrane depolarization, monoatomic cation transmembrane transport, monoatomic ion transmembrane transport, monoatomic ion transport, sensory perception of smell; MF: bicarbonate channel activity, channel activity, chloride channel activity, intracellularly ligand-gated monoatomic ion channel activity, ligand-gated monoatomic anion channel activity, ligand-gated monoatomic cation channel activity, metal ion binding; CC: basolateral plasma membrane, chloride channel complex, cilium, membrane, plasma membrane
Pathways: Ion channel transport, Salivary secretion - Mus musculus (mouse), Stimuli-sensing channels, Transport of small molecules
UniProt: Q8BGM5
Entrez ID: 212989
|
Does Knockout of Prph2 in Colonic Cancer Cell Line causally result in tumorigenicity?
| 0
| 2,181
|
Knockout
|
Prph2
|
tumorigenicity
|
Colonic Cancer Cell Line
|
Gene: Prph2 (peripherin 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell adhesion, detection of light stimulus involved in visual perception, photoreceptor cell outer segment organization, protein heterooligomerization, protein homooligomerization, protein localization to plasma membrane, protein maturation, response to light stimulus, response to low light intensity stimulus, retina development in camera-type eye, visual perception; MF: protein binding, protein homodimerization activity; CC: cell projection, membrane, photoreceptor inner segment, photoreceptor outer segment, plasma membrane
Pathways:
UniProt: P15499
Entrez ID: 19133
|
Does Knockout of D930020B18Rik in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 2,403
|
Knockout
|
D930020B18Rik
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: D930020B18Rik (RIKEN cDNA D930020B18 gene)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: D6RIN2, D3Z3G0, D3YXS3, F6XLN3
Entrez ID: 216393
|
Does Knockout of Prmt6 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,679
|
Knockout
|
Prmt6
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Prmt6 (protein arginine N-methyltransferase 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, cellular response to stress, cellular senescence, chromatin organization, chromatin remodeling, methylation, negative regulation of DNA-templated transcription, negative regulation of transcription by RNA polymerase II, negative regulation of ubiquitin-dependent protein catabolic process, regulation of DNA-templated transcription, regulation of mitochondrion organization, regulation of signal transduction by p53 class mediator; MF: chromatin binding, histone H2AR3 methyltransferase activity, histone H3 methyltransferase activity, histone H3R2 methyltransferase activity, histone H4R3 methyltransferase activity, histone arginine N-methyltransferase activity, histone binding, histone methyltransferase activity, methyltransferase activity, protein binding, protein-arginine N-methyltransferase activity, protein-arginine omega-N asymmetric methyltransferase activity, protein-arginine omega-N monomethyltransferase activity, transferase activity; CC: nucleolus, nucleoplasm, nucleus
Pathways: Chromatin modifying enzymes, Chromatin organization, Gene expression (Transcription), Generic Transcription Pathway, RMTs methylate histone arginines, RNA Polymerase II Transcription, RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function, Transcriptional regulation by RUNX1
UniProt: Q6NZB1
Entrez ID: 99890
|
Does Knockout of Gstz1 in Mouse cell causally result in protein/peptide accumulation?
| 0
| 1,047
|
Knockout
|
Gstz1
|
protein/peptide accumulation
|
Mouse cell
|
Gene: Gstz1 (glutathione transferase zeta 1 (maleylacetoacetate isomerase))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: L-phenylalanine catabolic process, L-tyrosine catabolic process, aromatic amino acid metabolic process, cellular detoxification, glutathione metabolic process; MF: catalytic activity, glutathione transferase activity, identical protein binding, isomerase activity, maleylacetoacetate isomerase activity, protein homodimerization activity, transferase activity; CC: cytoplasm, cytosol, mitochondrial matrix, mitochondrion
Pathways: Aerobic respiration and respiratory electron transport, Biological oxidations, Glutathione conjugation, Metabolism, Metabolism of amino acids and derivatives, Phase II - Conjugation of compounds, Phenylalanine and tyrosine metabolism, Pyruvate metabolism, Regulation of pyruvate dehydrogenase (PDH) complex, Regulation of pyruvate metabolism, Tyrosine catabolism, Tyrosine metabolism - Mus musculus (mouse), glutathione-mediated detoxification, tyrosine degradation I
UniProt: Q9WVL0
Entrez ID: 14874
|
Does Knockout of Zscan30 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,261
|
Knockout
|
Zscan30
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Zscan30 (zinc finger and SCAN domain containing 30)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q149X8
Entrez ID: 328918
|
Does Knockout of Aida in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 163
|
Knockout
|
Aida
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Aida (axin interactor, dorsalization associated)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: determination of ventral identity, dorsal/ventral pattern formation, negative regulation of JNK cascade, negative regulation of Wnt signaling pathway, negative regulation of determination of dorsal identity, negative regulation of protein-containing complex assembly, regulation of protein-containing complex assembly; MF: phosphatidylinositol binding, protein binding, protein domain specific binding; CC: cytoplasm, membrane
Pathways:
UniProt: Q8C4Q6
Entrez ID: 108909
|
Does Knockout of Arap1 in Neuroblastoma Cell Line causally result in response to virus?
| 0
| 1,422
|
Knockout
|
Arap1
|
response to virus
|
Neuroblastoma Cell Line
|
Gene: Arap1 (ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of stress fiber assembly, photoreceptor cell maintenance, positive regulation of DNA-templated transcription, positive regulation of cellular component organization, positive regulation of filopodium assembly, positive regulation of phagocytosis, positive regulation of receptor recycling, regulation of actin cytoskeleton organization, regulation of bone resorption, regulation of cell projection organization, regulation of cell shape, regulation of endocytosis, regulation of receptor internalization, signal transduction, transforming growth factor beta receptor signaling pathway; MF: DNA-binding transcription factor activity, GTPase activator activity, R-SMAD binding, RNA polymerase II-specific DNA-binding transcription factor binding, metal ion binding, phosphatidylinositol-3,4,5-trisphosphate binding, transcription cis-regulatory region binding, type 1 angiotensin receptor binding, zinc ion binding; CC: Golgi apparatus, Golgi cisterna membrane, anchoring junction, cell projection, cytoplasm, cytosol, early endosome, endosome, extrinsic component of plasma membrane, membrane, multivesicular body, nucleoplasm, plasma membrane, podosome, ruffle, trans-Golgi network
Pathways: CDC42 GTPase cycle, Endocytosis - Mus musculus (mouse), PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1, RAC1 GTPase cycle, RHO GTPase cycle, RHOA GTPase cycle, Signal Transduction, Signaling by Non-Receptor Tyrosine Kinases, Signaling by PTK6, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q4LDD4
Entrez ID: 69710
|
Does Knockout of Hormad2 in Mouse cell causally result in protein/peptide accumulation?
| 0
| 1,047
|
Knockout
|
Hormad2
|
protein/peptide accumulation
|
Mouse cell
|
Gene: Hormad2 (HORMA domain containing 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: meiotic cell cycle, meiotic sister chromatid cohesion; CC: centrosome, chromosome, cytosol, nucleoplasm, nucleus, synaptonemal complex
Pathways:
UniProt: Q5SQP1
Entrez ID: 75828
|
Does Knockout of Ankrd17 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Ankrd17
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Ankrd17 (ankyrin repeat domain 17)
Type: protein-coding
Summary: This gene encodes a protein with ankyrin repeats, which are associated with protein-protein interactions. Studies suggest that this protein is involved in liver development. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: blood vessel maturation, defense response to bacterium, endoderm development, immune system process, innate immune response, negative regulation of smooth muscle cell differentiation, positive regulation of G1/S transition of mitotic cell cycle, positive regulation of MDA-5 signaling pathway, positive regulation of RIG-I signaling pathway, positive regulation of canonical NF-kappaB signal transduction, positive regulation of cell cycle, regulation of DNA replication; MF: RNA binding, chromatin binding, nucleic acid binding; CC: chromatin, cytoplasm, male germ cell nucleus, nuclear membrane, nucleoplasm, nucleus
Pathways:
UniProt: Q99NH0
Entrez ID: 81702
|
Does Knockout of Ncln in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,269
|
Knockout
|
Ncln
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Ncln (nicalin)
Type: protein-coding
Summary: Predicted to enable ribosome binding activity. Predicted to be involved in several processes, including multi-pass transmembrane protein insertion into ER membrane; protein stabilization; and regulation of protein complex stability. Predicted to be part of multi-pass translocon complex. Predicted to be active in endoplasmic reticulum membrane. Is expressed in neural retinal epithelium; retina inner nuclear layer; retina nuclear layer; and retina outer nuclear layer. Orthologous to human NCLN (nicalin). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: multi-pass transmembrane protein insertion into ER membrane, protein stabilization, regulation of protein complex stability, regulation of protein-containing complex assembly, regulation of signal transduction; MF: ribosome binding; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane, multi-pass translocon complex, protein-containing complex
Pathways:
UniProt: Q8VCM8
Entrez ID: 103425
|
Does Knockout of Ackr4 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,684
|
Knockout
|
Ackr4
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Ackr4 (atypical chemokine receptor 4)
Type: protein-coding
Summary: Predicted to enable C-C chemokine binding activity and C-C chemokine receptor activity. Predicted to be involved in several processes, including calcium-mediated signaling; cell chemotaxis; and positive regulation of cytosolic calcium ion concentration. Predicted to be located in early endosome; plasma membrane; and recycling endosome. Predicted to be active in external side of plasma membrane. Is expressed in several structures, including central nervous system; gut; immune system; male reproductive gland or organ; and sensory organ. Orthologous to human ACKR4 (atypical chemokine receptor 4). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: G protein-coupled receptor signaling pathway, calcium-mediated signaling, cell chemotaxis, chemokine-mediated signaling pathway, chemotaxis, immune response, positive regulation of cytosolic calcium ion concentration, signal transduction, vesicle-mediated transport; MF: C-C chemokine binding, C-C chemokine receptor activity, G protein-coupled receptor activity, chemokine binding, chemokine receptor activity, scavenger receptor activity; CC: early endosome, endosome, external side of plasma membrane, membrane, plasma membrane, recycling endosome
Pathways: Chemokine receptors bind chemokines, Class A/1 (Rhodopsin-like receptors), Cytokine-cytokine receptor interaction - Mus musculus (mouse), GPCR ligand binding, Peptide ligand-binding receptors, Signal Transduction, Signaling by GPCR, Viral protein interaction with cytokine and cytokine receptor - Mus musculus (mouse)
UniProt: Q924I3
Entrez ID: 252837
|
Does Knockout of Nmi in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,276
|
Knockout
|
Nmi
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Nmi (N-myc (and STAT) interactor)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: immune system process, innate immune response, macrophage activation involved in immune response, negative regulation of cell population proliferation, negative regulation of innate immune response, negative regulation of interferon-alpha production, negative regulation of interferon-beta production, negative regulation of non-canonical NF-kappaB signal transduction, negative regulation of type I interferon production, positive regulation of inflammatory response, positive regulation of innate immune response, positive regulation of non-canonical NF-kappaB signal transduction, positive regulation of protein K48-linked ubiquitination, response to virus, toll-like receptor 4 signaling pathway; MF: identical protein binding, protein binding; CC: cytoplasm, cytosol, extracellular region, extracellular space, membrane, nucleoplasm, nucleus
Pathways:
UniProt: O35309
Entrez ID: 64685
|
Does Knockout of Pcdhga2 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 688
|
Knockout
|
Pcdhga2
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Pcdhga2 (protocadherin gamma subfamily A, 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell adhesion, homophilic cell adhesion via plasma membrane adhesion molecules; MF: calcium ion binding, cell adhesion molecule binding, molecular_function; CC: membrane, plasma membrane
Pathways:
UniProt: Q91XY6
Entrez ID: 93710
|
Does Knockout of Nudc in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,281
|
Knockout
|
Nudc
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Nudc (nudC nuclear distribution protein)
Type: protein-coding
Summary: Predicted to enable unfolded protein binding activity. Predicted to be involved in several processes, including mitotic metaphase chromosome alignment; mitotic spindle organization; and protein folding. Predicted to be located in cytosol; midbody; and mitotic spindle. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Orthologous to human NUDC (nuclear distribution C, dynein complex regulator). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: cell division, establishment of organelle localization, mitotic metaphase chromosome alignment, mitotic spindle organization, nuclear migration, protein folding, response to peptide hormone; MF: protein binding, unfolded protein binding; CC: cytoplasm, cytoskeleton, cytosol, microtubule, midbody, mitotic spindle, nucleus, spindle
Pathways: Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal, Amplification of signal from the kinetochores, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, EML4 and NUDC in mitotic spindle formation, M Phase, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Mitotic Spindle Checkpoint, RHO GTPase Effectors, RHO GTPase cycle, RHO GTPases Activate Formins, RND2 GTPase cycle, Resolution of Sister Chromatid Cohesion, Separation of Sister Chromatids, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: O35685
Entrez ID: 18221
|
Does Knockout of 1110065P20Rik in Melanoma Cell Line causally result in protein/peptide accumulation?
| 0
| 1,839
|
Knockout
|
1110065P20Rik
|
protein/peptide accumulation
|
Melanoma Cell Line
|
Gene: 1110065P20Rik (RIKEN cDNA 1110065P20 gene)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: B1ARW8
Entrez ID: 68920
|
Does Knockout of Pcsk5 in Mouse cell causally result in protein/peptide accumulation?
| 0
| 1,047
|
Knockout
|
Pcsk5
|
protein/peptide accumulation
|
Mouse cell
|
Gene: Pcsk5 (proprotein convertase subtilisin/kexin type 5)
Type: protein-coding
Summary: This gene encodes a subtilisin-like proprotein convertase that mediates posttranslational endoproteolytic processing of various proprotein substrates traversing the secretory pathway. The encoded protein is an inactive zymogen that undergoes autoproteolytic processing in the endoplasmic reticulum and the Golgi network to generate an active enzyme. Mice lacking the encoded protein die at an early embryonic stage. Conditional inactivation this gene in the epiblast but not in the extraembryonic tissue bypasses embryonic lethality but results in death at birth. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2015].
Gene Ontology: BP: anterior/posterior pattern specification, cardiac septum development, coronary vasculature development, cytokine precursor processing, determination of left/right symmetry, embryo implantation, embryonic digestive tract development, embryonic skeletal system development, female pregnancy, heart development, kidney development, limb morphogenesis, peptide biosynthetic process, peptide hormone processing, positive regulation of integrin activation, positive regulation of integrin-mediated signaling pathway, positive regulation of smooth muscle cell-matrix adhesion, positive regulation of vascular associated smooth muscle cell migration, protein processing, proteolysis, respiratory tube development, signal peptide processing, viral life cycle; MF: endopeptidase activity, hydrolase activity, peptidase activity, peptide binding, serine-type endopeptidase activity, serine-type peptidase activity; CC: Golgi apparatus, Golgi medial cisterna, Golgi membrane, cytoplasmic vesicle, endomembrane system, endoplasmic reticulum lumen, extracellular region, extracellular space, membrane, perikaryon, proximal dendrite, secretory granule, trans-Golgi network
Pathways: Assembly of active LPL and LIPC lipase complexes, Expression and Processing of Neurotrophins, NGF processing, Plasma lipoprotein assembly, remodeling, and clearance, Plasma lipoprotein remodeling, Signal Transduction, Signaling by NTRKs, Signaling by Receptor Tyrosine Kinases, Transport of small molecules
UniProt: Q04592
Entrez ID: 18552
|
Does Knockout of Topbp1 in Regulatory T cell causally result in protein/peptide accumulation?
| 0
| 1,481
|
Knockout
|
Topbp1
|
protein/peptide accumulation
|
Regulatory T cell
|
Gene: Topbp1 (topoisomerase (DNA) II binding protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage checkpoint signaling, DNA damage response, DNA repair, DNA replication checkpoint signaling, DNA replication initiation, broken chromosome clustering, chromatin organization, chromosome organization, double-strand break repair, double-strand break repair via alternative nonhomologous end joining, double-strand break repair via classical nonhomologous end joining, double-strand break repair via homologous recombination, homologous recombination, mitotic DNA replication checkpoint signaling, mitotic G2 DNA damage checkpoint signaling, protein localization to site of double-strand break, reciprocal meiotic recombination, response to ionizing radiation; MF: DNA binding, chromatin-protein adaptor activity, identical protein binding, phosphorylation-dependent protein binding, protein serine/threonine kinase activator activity; CC: BRCA1-B complex, PML body, actin cytoskeleton, centrosome, chromosome, condensed nuclear chromosome, cytoplasm, cytoskeleton, male germ cell nucleus, nuclear body, nucleoplasm, nucleus, plasma membrane, site of DNA damage, site of double-strand break, spindle pole
Pathways: Cell Cycle, Cell Cycle Checkpoints, DNA Double-Strand Break Repair, DNA Repair, G2/M Checkpoints, G2/M DNA damage checkpoint, Gene expression (Transcription), Generic Transcription Pathway, HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), HDR through Single Strand Annealing (SSA), Homologous recombination - Mus musculus (mouse), Homology Directed Repair, Processing of DNA double-strand break ends, RNA Polymerase II Transcription, Regulation of TP53 Activity, Regulation of TP53 Activity through Phosphorylation, Transcriptional Regulation by TP53
UniProt: Q6ZQF0
Entrez ID: 235559
|
Does Knockout of Ptf1a in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,260
|
Knockout
|
Ptf1a
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Ptf1a (pancreas specific transcription factor, 1a)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: amacrine cell differentiation, cell differentiation, cell fate commitment, central nervous system neuron differentiation, cerebellum development, developmental process, exocrine pancreas development, generation of neurons, hindbrain development, nervous system development, neuron fate commitment, pancreas development, positive regulation of DNA-templated transcription, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of neural retina development, regulation of transcription by RNA polymerase II, retina layer formation, retina morphogenesis in camera-type eye, retinoic acid receptor signaling pathway, tissue development; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, RNA polymerase II-specific, E-box binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, chromatin binding, protein binding, protein dimerization activity, sequence-specific DNA binding, sequence-specific double-stranded DNA binding; CC: cytoplasm, cytosol, nucleoplasm, nucleus, transcription regulator complex
Pathways:
UniProt: Q9QX98
Entrez ID: 19213
|
Does Knockout of Echdc3 in macrophage causally result in phagocytosis?
| 0
| 1,890
|
Knockout
|
Echdc3
|
phagocytosis
|
macrophage
|
Gene: Echdc3 (enoyl Coenzyme A hydratase domain containing 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: fatty acid metabolic process, lipid metabolic process, positive regulation of cellular response to insulin stimulus; MF: enoyl-CoA hydratase activity, hydro-lyase activity; CC: mitochondrion
Pathways:
UniProt: Q9D7J9
Entrez ID: 67856
|
Does Knockout of Erich4 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 84
|
Knockout
|
Erich4
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Erich4 (glutamate rich 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q3UNU4
Entrez ID: 632778
|
Does Knockout of Mlxip in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,260
|
Knockout
|
Mlxip
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Mlxip (MLX interacting protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: nucleocytoplasmic transport, positive regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding, protein binding, protein dimerization activity; CC: RNA polymerase II transcription regulator complex, cytoplasm, membrane, mitochondrial outer membrane, mitochondrion, nucleus
Pathways: Insulin resistance - Mus musculus (mouse), Non-alcoholic fatty liver disease - Mus musculus (mouse)
UniProt: Q2VPU4
Entrez ID: 208104
|
Does Knockout of Hsf4 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,275
|
Knockout
|
Hsf4
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Hsf4 (heat shock transcription factor 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: lens fiber cell differentiation, negative regulation of DNA-templated transcription, negative regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, identical protein binding, protein phosphatase binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding; CC: chromatin, nuclear speck, nucleus
Pathways:
UniProt: Q9R0L1
Entrez ID: 26386
|
Does Knockout of Aip in renal medulla cell line causally result in response to bacteria?
| 0
| 2,049
|
Knockout
|
Aip
|
response to bacteria
|
renal medulla cell line
|
Gene: Aip (aryl-hydrocarbon receptor-interacting protein)
Type: protein-coding
Summary: This gene encodes an Hsp90-associated protein that is localized to the cytoplasm. The encoded protein interacts with the aryl hydrocarbon receptor (AhR) and the tyrosine kinase receptor RET, inhibits AhR ubiquitination, and regulates the intracellular localization of AhR. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013].
Gene Ontology: BP: protein kinase A signaling, protein maturation, protein targeting to mitochondrion, xenobiotic metabolic process; MF: GAF domain binding, aryl hydrocarbon receptor binding, enzyme binding, peptidyl-prolyl cis-trans isomerase activity, protein binding, transcription coregulator activity, unfolded protein binding; CC: aryl hydrocarbon receptor complex, cytoplasm, cytosol, membrane, plasma membrane
Pathways: Aryl hydrocarbon receptor signalling, Biological oxidations, Chemical carcinogenesis - receptor activation - Mus musculus (mouse), Cushing syndrome - Mus musculus (mouse), Metabolism, Phase I - Functionalization of compounds
UniProt: O08915
Entrez ID: 11632
|
Does Knockout of Actc1 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,267
|
Knockout
|
Actc1
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Actc1 (actin, alpha, cardiac muscle 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: actin filament organization, actin filament-based movement, actin-myosin filament sliding, actomyosin structure organization, cardiac muscle contraction, cardiac muscle tissue morphogenesis, cardiac myofibril assembly, cytoplasmic actin-based contraction involved in cell motility, heart contraction, mesenchyme migration, negative regulation of apoptotic process, positive regulation of gene expression, response to ethanol, response to xenobiotic stimulus, skeletal muscle thin filament assembly; MF: ATP binding, hydrolase activity, microfilament motor activity, myosin binding, nucleotide binding, protein binding; CC: I band, actin cytoskeleton, actin filament, cell body, cytoplasm, cytoskeleton, filopodium, glutamatergic synapse, lamellipodium, sarcomere, synapse
Pathways: Adherens junctions interactions, Adrenergic signaling in cardiomyocytes - Mus musculus (mouse), Cardiac muscle contraction - Mus musculus (mouse), Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Dilated cardiomyopathy - Mus musculus (mouse), Extracellular matrix organization, Formation of the dystrophin-glycoprotein complex (DGC), Hypertrophic cardiomyopathy - Mus musculus (mouse), Muscle contraction, Non-integrin membrane-ECM interactions, RHO GTPase cycle, RHOA GTPase cycle, RHOB GTPase cycle, Regulation of CDH1 Expression and Function, Regulation of CDH1 Function, Regulation of Expression and Function of Type I Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Striated Muscle Contraction
UniProt: P68033
Entrez ID: 11464
|
Does Knockout of Tinf2 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 2,488
|
Knockout
|
Tinf2
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Tinf2 (Terf1 (TRF1)-interacting nuclear factor 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of epithelial cell proliferation, negative regulation of telomere maintenance, negative regulation of telomere maintenance via telomerase, positive regulation of telomere maintenance, protein localization to chromosome, telomeric region, regulation of telomere maintenance via telomere lengthening, telomere assembly, telomere capping; MF: protein binding, telomeric DNA binding; CC: chromosome, chromosome, telomeric region, nuclear body, nuclear telomere cap complex, nucleoplasm, nucleus, perinucleolar chromocenter, shelterin complex
Pathways:
UniProt: A0A2I3BRL3, Q8K1K3, A0A2I3BRI7, A0A2I3BRW2, A0A2I3BPS4
Entrez ID: 28113
|
Does Knockout of Gpr15 in renal medulla cell line causally result in response to bacteria?
| 0
| 2,049
|
Knockout
|
Gpr15
|
response to bacteria
|
renal medulla cell line
|
Gene: Gpr15 (G protein-coupled receptor 15)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, T cell migration, adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway, angiogenesis, signal transduction, symbiont entry into host cell; MF: G protein-coupled receptor activity, coreceptor activity, virus receptor activity; CC: cytoplasm, endosome, membrane, plasma membrane
Pathways: G alpha (s) signalling events, GPCR downstream signalling, Signal Transduction, Signaling by GPCR
UniProt: Q0VDU3
Entrez ID: 71223
|
Does Knockout of Paip1 in Embryonic Fibroblast Cell Line causally result in response to virus?
| 0
| 1,133
|
Knockout
|
Paip1
|
response to virus
|
Embryonic Fibroblast Cell Line
|
Gene: Paip1 (polyadenylate binding protein-interacting protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: CRD-mediated mRNA stabilization, host-mediated activation of viral process, negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay, positive regulation of cytoplasmic translation, regulation of translation, regulation of translational initiation; MF: RNA binding, protein binding, translation activator activity; CC: cytoplasm, cytosol, mCRD-mediated mRNA stability complex
Pathways: Deadenylation of mRNA, Deadenylation-dependent mRNA decay, Metabolism of RNA
UniProt: Q8VE62
Entrez ID: 218693
|
Does Knockout of Brca1 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 2,307
|
Knockout
|
Brca1
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Brca1 (breast cancer 1, early onset)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA recombination, DNA repair, DNA strand resection involved in replication fork processing, cellular response to indole-3-methanol, cellular response to ionizing radiation, cellular response to tumor necrosis factor, centrosome cycle, centrosome duplication, chordate embryonic development, chromosome segregation, double-strand break repair, double-strand break repair via homologous recombination, fatty acid biosynthetic process, fatty acid metabolic process, homologous recombination, intrinsic apoptotic signaling pathway in response to DNA damage, lipid metabolic process, mitotic G2 DNA damage checkpoint signaling, mitotic G2/M transition checkpoint, negative regulation of DNA-templated transcription, negative regulation of cell growth, negative regulation of extrinsic apoptotic signaling pathway via death domain receptors, negative regulation of fatty acid biosynthetic process, negative regulation of gene expression via chromosomal CpG island methylation, negative regulation of intracellular estrogen receptor signaling pathway, negative regulation of reactive oxygen species metabolic process, positive regulation of DNA repair, positive regulation of DNA-templated transcription, positive regulation of angiogenesis, positive regulation of cell cycle, positive regulation of gene expression, positive regulation of protein import into nucleus, positive regulation of transcription by RNA polymerase II, positive regulation of vascular endothelial growth factor production, postreplication repair, protein K6-linked ubiquitination, protein autoubiquitination, protein ubiquitination, random inactivation of X chromosome, regulation of DNA damage checkpoint, regulation of DNA repair, regulation of cell cycle, regulation of transcription by RNA polymerase II, response to ionizing radiation, sex-chromosome dosage compensation; MF: DNA binding, RNA binding, RNA polymerase binding, chromatin binding, damaged DNA binding, enzyme binding, identical protein binding, metal ion binding, p53 binding, transcription cis-regulatory region binding, transcription coactivator activity, transferase activity, ubiquitin protein ligase activity, ubiquitin protein ligase binding, ubiquitin-protein transferase activity, zinc ion binding; CC: BRCA1-A complex, BRCA1-B complex, BRCA1-BARD1 complex, BRCA1-C complex, DNA repair complex, XY body, centrosome, chromosome, condensed chromosome, condensed nuclear chromosome, cytoplasm, intracellular organelle lumen, lateral element, male germ cell nucleus, mitochondrial matrix, nuclear body, nuclear ubiquitin ligase complex, nucleoplasm, nucleus, plasma membrane, protein-containing complex, ribonucleoprotein complex
Pathways: Breast cancer - Mus musculus (mouse), Cell Cycle, Cell Cycle Checkpoints, DNA Double Strand Break Response, DNA Double-Strand Break Repair, DNA Repair, Deubiquitination, Fanconi anemia pathway - Mus musculus (mouse), G2/M Checkpoints, G2/M DNA damage checkpoint, Gene expression (Transcription), Generic Transcription Pathway, HDR through Homologous Recombination (HRR), HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), HDR through Single Strand Annealing (SSA), Homologous DNA Pairing and Strand Exchange, Homologous recombination - Mus musculus (mouse), Homology Directed Repair, Metabolism of proteins, Metalloprotease DUBs, MicroRNAs in cancer - Mus musculus (mouse), Nonhomologous End-Joining (NHEJ), PI3K-Akt signaling pathway - Mus musculus (mouse), Post-translational protein modification, Presynaptic phase of homologous DNA pairing and strand exchange, Processing of DNA double-strand break ends, RNA Polymerase II Transcription, Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks, Regulation of TP53 Activity, Regulation of TP53 Activity through Phosphorylation, Resolution of D-Loop Structures, Resolution of D-loop Structures through Holliday Junction Intermediates, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of DNA damage response and repair proteins, Transcriptional Regulation by TP53, Ubiquitin mediated proteolysis - Mus musculus (mouse)
UniProt: P48754
Entrez ID: 12189
|
Does Knockout of Zhx3 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 688
|
Knockout
|
Zhx3
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Zhx3 (zinc fingers and homeoboxes 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell differentiation, negative regulation of DNA-templated transcription, negative regulation of transcription by RNA polymerase II, positive regulation of osteoblast differentiation, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II transcription regulatory region sequence-specific DNA binding, metal ion binding, protein binding, protein heterodimerization activity, protein homodimerization activity, zinc ion binding; CC: cell cortex, nucleoplasm, nucleus
Pathways:
UniProt: Q8C0Q2
Entrez ID: 320799
|
Does Knockout of Taar2 in macrophage causally result in phagocytosis?
| 0
| 1,888
|
Knockout
|
Taar2
|
phagocytosis
|
macrophage
|
Gene: Taar2 (trace amine-associated receptor 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, signal transduction; MF: G protein-coupled amine receptor activity, G protein-coupled receptor activity, trace-amine receptor activity; CC: membrane, plasma membrane
Pathways: Amine ligand-binding receptors, Class A/1 (Rhodopsin-like receptors), G alpha (s) signalling events, GPCR downstream signalling, GPCR ligand binding, Neuroactive ligand-receptor interaction - Mus musculus (mouse), Signal Transduction, Signaling by GPCR
UniProt: Q5QD17
Entrez ID: 209512
|
Does Knockout of Iqgap1 in breast epithelium causally result in cell cycle progression?
| 0
| 1,469
|
Knockout
|
Iqgap1
|
cell cycle progression
|
breast epithelium
|
Gene: Iqgap1 (IQ motif containing GTPase activating protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: MAPK cascade, caveola assembly, cell migration, cellular response to calcium ion, cellular response to epidermal growth factor stimulus, cellular response to fibroblast growth factor stimulus, cellular response to platelet-derived growth factor stimulus, epidermal growth factor receptor signaling pathway, fibroblast growth factor receptor signaling pathway, fibroblast migration, mitotic actomyosin contractile ring assembly actin filament organization, negative regulation of dephosphorylation, neuron projection extension, platelet-derived growth factor receptor signaling pathway, podocyte development, positive regulation of MAPK cascade, positive regulation of dendrite development, positive regulation of focal adhesion assembly, positive regulation of protein localization, positive regulation of vascular associated smooth muscle cell migration, regulation of cytokine production, regulation of mitotic cell cycle, regulation of postsynapse assembly, response to angiotensin; MF: GTPase activator activity, MAP-kinase scaffold activity, S100 protein binding, actin filament binding, calcium ion binding, calmodulin binding, mitogen-activated protein kinase binding, molecular adaptor activity, phosphatidylinositol-3,4,5-trisphosphate binding, protein binding, protein domain specific binding, protein kinase binding, protein phosphatase binding, protein serine/threonine kinase activator activity, protein-containing complex binding, small GTPase binding; CC: actin cytoskeleton, apical plasma membrane, axon, basolateral plasma membrane, cell cortex, cell leading edge, cell-cell junction, cortical actin cytoskeleton, cytoplasm, cytoplasmic ribonucleoprotein granule, cytoplasmic side of plasma membrane, focal adhesion, growth cone, lateral plasma membrane, membrane, microtubule, microtubule cytoskeleton, midbody, neuron projection, nucleus, plasma membrane, plasma membrane bounded cell projection, postsynapse, protein-containing complex, ribonucleoprotein complex, ruffle, slit diaphragm
Pathways: Adherens junction - Mus musculus (mouse), Cell-Cell communication, Immune System, Innate Immune System, MAP2K and MAPK activation, MAPK family signaling cascades, MAPK1/MAPK3 signaling, Nephrin family interactions, Neutrophil degranulation, Proteoglycans in cancer - Mus musculus (mouse), RAC1 GTPase cycle, RAC2 GTPase cycle, RAF/MAP kinase cascade, RHO GTPase Effectors, RHO GTPase cycle, RHO GTPases activate IQGAPs, RHOA GTPase cycle, RHOC GTPase cycle, RHOQ GTPase cycle, RHOU GTPase cycle, RHOV GTPase cycle, Regulation of actin cytoskeleton - Mus musculus (mouse), Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q9JKF1
Entrez ID: 29875
|
Does Knockout of Hgf in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,266
|
Knockout
|
Hgf
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Hgf (hepatocyte growth factor)
Type: protein-coding
Summary: This gene encodes a protein that binds to the hepatocyte growth factor receptor to regulate cell growth, cell motility and morphogenesis in numerous cell and tissue types. The encoded preproprotein is proteolytically processed to generate multiple protein products, including the hepatocyte growth factor alpha and beta chains, which heterodimerize to form the mature active protein. Although this protein is a member of the peptidase S1 family of serine proteases, it lacks peptidase activity. Homozygous knockout mice for this gene exhibit embryonic lethality due to impaired development of the placenta and liver. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015].
Gene Ontology: BP: animal organ development, cell chemotaxis, cell morphogenesis, cellular response to hepatocyte growth factor stimulus, epithelial cell proliferation, hepatocyte growth factor receptor signaling pathway, liver development, myoblast proliferation, negative regulation of apoptotic process, negative regulation of extrinsic apoptotic signaling pathway via death domain receptors, negative regulation of hydrogen peroxide-mediated programmed cell death, negative regulation of inflammatory response, negative regulation of interleukin-6 production, negative regulation of release of cytochrome c from mitochondria, positive chemotaxis, positive regulation of DNA biosynthetic process, positive regulation of MAPK cascade, positive regulation of angiogenesis, positive regulation of cell migration, positive regulation of interleukin-10 production, positive regulation of myelination, positive regulation of neuron projection regeneration, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, proteolysis, regulation of anatomical structure morphogenesis, regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling, regulation of multicellular organismal process, regulation of p38MAPK cascade, signal transduction, skeletal muscle cell proliferation; MF: chemoattractant activity, endopeptidase activity, growth factor activity, identical protein binding, protein binding, protein-containing complex binding, signaling receptor binding; CC: extracellular region, extracellular space
Pathways: Calcium signaling pathway - Mus musculus (mouse), Chemical carcinogenesis - reactive oxygen species - Mus musculus (mouse), Drug-mediated inhibition of MET activation, Focal adhesion - Mus musculus (mouse), Gastric cancer - Mus musculus (mouse), Hemostasis, Hepatocellular carcinoma - Mus musculus (mouse), Intracellular signaling by second messengers, MAPK family signaling cascades, MAPK signaling pathway - Mus musculus (mouse), MAPK1/MAPK3 signaling, MET Receptor Activation, MET activates PI3K/AKT signaling, MET activates PTK2 signaling, MET activates PTPN11, MET activates RAP1 and RAC1, MET activates RAS signaling, MET activates STAT3, MET interacts with TNS proteins, MET promotes cell motility, MET receptor recycling, Malaria - Mus musculus (mouse), Melanoma - Mus musculus (mouse), Negative regulation of MET activity, Negative regulation of the PI3K/AKT network, Non-small cell lung cancer - Mus musculus (mouse), PI3K-Akt signaling pathway - Mus musculus (mouse), PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling, PIP3 activates AKT signaling, Pathways in cancer - Mus musculus (mouse), Platelet activation, signaling and aggregation, Platelet degranulation , Proteoglycans in cancer - Mus musculus (mouse), RAF/MAP kinase cascade, Rap1 signaling pathway - Mus musculus (mouse), Ras signaling pathway - Mus musculus (mouse), Renal cell carcinoma - Mus musculus (mouse), Response to elevated platelet cytosolic Ca2+, Signal Transduction, Signaling by MET, Signaling by Receptor Tyrosine Kinases
UniProt: Q08048
Entrez ID: 15234
|
Does Knockout of Ror1 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,281
|
Knockout
|
Ror1
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Ror1 (receptor tyrosine kinase-like orphan receptor 1)
Type: protein-coding
Summary: This gene encodes a receptor tyrosine kinase that has been implicated in nervous system development, specifically in the maintenance of neural progenitor cell fate, neurite extension and synapse formation. The encoded protein, likely a pseudokinase that lacks catalytic activity, may also regulate adipogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015].
Gene Ontology: BP: Wnt signaling pathway, astrocyte development, cell population proliferation, cell surface receptor protein tyrosine kinase signaling pathway, inner ear development, positive regulation of NF-kappaB transcription factor activity, positive regulation of canonical NF-kappaB signal transduction, sensory perception of sound; MF: ATP binding, Wnt receptor activity, Wnt-protein binding, nucleotide binding, protein kinase activity, signaling receptor activity, transmembrane receptor protein tyrosine kinase activity; CC: axon, axon terminus, cell projection, cell surface, membrane, plasma membrane, receptor complex, stress fiber
Pathways: Beta-catenin independent WNT signaling, PCP/CE pathway, Signal Transduction, Signaling by WNT, WNT5A-dependent internalization of FZD2, FZD5 and ROR2, Wnt signaling pathway - Mus musculus (mouse)
UniProt: Q9Z139
Entrez ID: 26563
|
Does Knockout of Gm19345 in Neuroblastoma Cell Line causally result in response to virus?
| 0
| 1,422
|
Knockout
|
Gm19345
|
response to virus
|
Neuroblastoma Cell Line
|
Gene: Gm19345 (predicted gene, 19345)
Type: protein-coding
Summary: predicted gene, 19345
Gene Ontology:
Pathways:
UniProt: G3UYD9
Entrez ID: 100502736
|
Does Knockout of Fst in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,266
|
Knockout
|
Fst
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Fst (follistatin)
Type: protein-coding
Summary: The protein encoded by this gene binds to and negatively regulates activin, as well as other members of the transforming growth factor beta family, and acts to prevent uncontrolled cellular proliferation. This protein also contains a heparin-binding sequence. It is expressed in many of the tissues in which activin is synthesized and is thought to clear activin from the circulation by attachment to the cell surface. Alternative splicing results in multiple transcript variants that encode multiple protein isoforms, including FST315 and FST288, that differ at their C-terminus. Another isoform, FST303 is thought to be produced by proteolytic cleavage of FST315. These isoforms differ in their localization and in their ability to bind heparin. While FST315 is a circulating protein, FST288 is tissue-bound, and FST303 is gonad-specific. While deletion of all isoforms results in embryonic lethality, expression of just FST288 is sufficient for embryonic development, but the resultant mice have fertility defects. [provided by RefSeq, Aug 2014].
Gene Ontology: BP: BMP signaling pathway, ameloblast differentiation, cell differentiation, cellular response to growth factor stimulus, female gonad development, gamete generation, hair follicle morphogenesis, hematopoietic progenitor cell differentiation, keratinocyte proliferation, negative regulation of activin receptor signaling pathway, negative regulation of epithelial cell differentiation, negative regulation of transcription by RNA polymerase II, odontogenesis of dentin-containing tooth, pattern specification process, positive regulation of hair follicle development, regulation of BMP signaling pathway, skeletal system development; MF: activin binding, activin receptor antagonist activity, heparan sulfate proteoglycan binding; CC: cytoplasm, extracellular region, extracellular space, nucleolus, nucleus
Pathways: Antagonism of Activin by Follistatin, Signal Transduction, Signaling by Activin, Signaling by TGFB family members, TGF-beta signaling pathway - Mus musculus (mouse)
UniProt: P47931
Entrez ID: 14313
|
Does Knockout of Sema4b in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,271
|
Knockout
|
Sema4b
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Sema4b (sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: axon guidance, cell differentiation, negative chemotaxis, nervous system development, neural crest cell migration, positive regulation of cell migration, semaphorin-plexin signaling pathway; MF: chemorepellent activity, neuropilin binding, protein binding, semaphorin receptor binding; CC: glutamatergic synapse, membrane, plasma membrane, postsynaptic density membrane, synapse
Pathways: Axon guidance - Mus musculus (mouse)
UniProt: Q62179
Entrez ID: 20352
|
Does Knockout of Ccnl2 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,266
|
Knockout
|
Ccnl2
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Ccnl2 (cyclin L2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: regulation of RNA splicing, regulation of apoptotic process, regulation of cell cycle, regulation of centrosome cycle, regulation of transcription by RNA polymerase II; MF: cyclin-dependent protein serine/threonine kinase regulator activity, protein binding; CC: cyclin-dependent protein kinase holoenzyme complex, nuclear speck, nucleoplasm, nucleus
Pathways:
UniProt: Q9JJA7
Entrez ID: 56036
|
Does Knockout of Mbd3l1 in Embryonic Fibroblast Cell Line causally result in cell proliferation?
| 0
| 345
|
Knockout
|
Mbd3l1
|
cell proliferation
|
Embryonic Fibroblast Cell Line
|
Gene: Mbd3l1 (methyl-CpG binding domain protein 3-like 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA methylation-dependent constitutive heterochromatin formation, negative regulation of transcription by RNA polymerase II; CC: nucleus
Pathways:
UniProt: Q9D9H3
Entrez ID: 73503
|
Does Knockout of Tbc1d7 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,282
|
Knockout
|
Tbc1d7
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Tbc1d7 (TBC1 domain family, member 7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: activation of GTPase activity, cellular response to starvation, negative regulation of TOR signaling, negative regulation of TORC1 signaling, negative regulation of cilium assembly, positive regulation of protein ubiquitination, response to growth factor; MF: GTPase activator activity, TSC1-TSC2 complex binding, small GTPase binding; CC: TSC1-TSC2 complex, ciliary basal body, cytoplasm, cytoplasmic vesicle, cytosol, lysosomal membrane, lysosome, membrane
Pathways: Membrane Trafficking, Rab regulation of trafficking, TBC/RABGAPs, Vesicle-mediated transport, mTOR signaling pathway - Mus musculus (mouse)
UniProt: Q9D0K0
Entrez ID: 67046
|
Does Knockout of Zmynd15 in macrophage causally result in phagocytosis?
| 0
| 1,888
|
Knockout
|
Zmynd15
|
phagocytosis
|
macrophage
|
Gene: Zmynd15 (zinc finger, MYND-type containing 15)
Type: protein-coding
Summary: Enables histone deacetylase binding activity. Acts upstream of or within negative regulation of DNA-templated transcription and spermatid development. Located in cytoplasm and male germ cell nucleus. Is expressed in central nervous system and retina. Human ortholog(s) of this gene implicated in spermatogenic failure 14. Orthologous to human ZMYND15 (zinc finger MYND-type containing 15). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: cell differentiation, negative regulation of DNA-templated transcription, spermatid development, spermatogenesis; MF: histone deacetylase binding, metal ion binding, zinc ion binding; CC: cytoplasm, male germ cell nucleus, nucleus
Pathways:
UniProt: Q8C0R7
Entrez ID: 574428
|
Does Knockout of Gm15455 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 81
|
Knockout
|
Gm15455
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Gm15455 (predicted gene 15455)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt:
Entrez ID: 433287
|
Does Knockout of Dclre1a in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,683
|
Knockout
|
Dclre1a
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Dclre1a (DNA cross-link repair 1A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, cell division, double-strand break repair via nonhomologous end joining, interstrand cross-link repair, nucleotide-excision repair; MF: 5'-3' DNA exonuclease activity, DNA binding, beta-lactamase activity, damaged DNA binding, hydrolase activity, metal ion binding, zinc ion binding; CC: fibrillar center, nucleoplasm, nucleus
Pathways:
UniProt: S4R284, S4R1N2
Entrez ID: 55947
|
Does Knockout of Smndc1 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 1
| 1,266
|
Knockout
|
Smndc1
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Smndc1 (survival motor neuron domain containing 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, apoptotic process, mRNA processing; CC: Cajal body, cytoplasm, nuclear speck, nucleus, spliceosomal complex
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, Spliceosome - Mus musculus (mouse), mRNA Splicing, mRNA Splicing - Major Pathway
UniProt: Q8BGT7
Entrez ID: 76479
|
Does Knockout of Defb36 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,680
|
Knockout
|
Defb36
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Defb36 (defensin beta 36)
Type: protein-coding
Summary: Predicted to be involved in defense response to bacterium and innate immune response. Predicted to be located in extracellular region. Orthologous to human DEFB123 (defensin beta 123). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: defense response, defense response to bacterium, innate immune response
Pathways: Antimicrobial peptides, Beta defensins, Defensins, Immune System, Innate Immune System
UniProt: Q8K3U4
Entrez ID: 266620
|
Does Knockout of Sarnp in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 1
| 1,565
|
Knockout
|
Sarnp
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Sarnp (SAP domain containing ribonucleoprotein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mRNA export from nucleus, mRNA transport, negative regulation of transcription by RNA polymerase II, poly(A)+ mRNA export from nucleus, regulation of translation; MF: DNA binding, RNA binding, chromatin binding; CC: cytoplasmic ribonucleoprotein granule, nuclear speck, nucleus, transcription export complex
Pathways: Gene expression (Transcription), Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, RNA Polymerase II Transcription, RNA Polymerase II Transcription Termination, Transport of Mature Transcript to Cytoplasm, Transport of Mature mRNA derived from an Intron-Containing Transcript, mRNA 3'-end processing
UniProt: Q9D1J3
Entrez ID: 66118
|
Does Knockout of Olfml2a in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,260
|
Knockout
|
Olfml2a
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Olfml2a (olfactomedin-like 2A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: extracellular matrix organization, signal transduction; MF: extracellular matrix binding, identical protein binding; CC: extracellular matrix, extracellular region, extracellular space
Pathways:
UniProt: Q8BHP7
Entrez ID: 241327
|
Does Knockout of Acan in macrophage causally result in phagocytosis?
| 0
| 1,890
|
Knockout
|
Acan
|
phagocytosis
|
macrophage
|
Gene: Acan (aggrecan)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cartilage condensation, cartilage development, cell adhesion, central nervous system development, chondrocyte development, collagen fibril organization, heart development, negative regulation of cell migration, proteoglycan biosynthetic process, skeletal system development; MF: calcium ion binding, carbohydrate binding, hyaluronic acid binding, metal ion binding, protein binding; CC: GABA-ergic synapse, basement membrane, extracellular matrix, extracellular region, extracellular space, glutamatergic synapse, neuronal cell body, perineuronal net, perisynaptic extracellular matrix, synapse
Pathways: Degradation of the extracellular matrix, ECM proteoglycans, Extracellular matrix organization, Glycosaminoglycan metabolism, Keratan sulfate biosynthesis, Keratan sulfate degradation, Keratan sulfate/keratin metabolism, Metabolism, Metabolism of carbohydrates and carbohydrate derivatives
UniProt: Q61282
Entrez ID: 11595
|
Does Knockout of Ctxn2 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,274
|
Knockout
|
Ctxn2
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Ctxn2 (cortexin 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cellular_component, membrane
Pathways:
UniProt: Q3URE8
Entrez ID: 381418
|
Does Knockout of Klrb1c in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,264
|
Knockout
|
Klrb1c
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Klrb1c (killer cell lectin-like receptor subfamily B member 1C)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: natural killer cell activation, positive regulation of natural killer cell mediated cytotoxicity, regulation of natural killer cell mediated cytotoxicity; MF: carbohydrate binding, identical protein binding, signaling receptor activity; CC: cell surface, external side of plasma membrane, membrane, plasma membrane
Pathways: Malaria - Mus musculus (mouse), Natural killer cell mediated cytotoxicity - Mus musculus (mouse)
UniProt: P27814
Entrez ID: 17059
|
Does Knockout of Nr4a3 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,289
|
Knockout
|
Nr4a3
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Nr4a3 (nuclear receptor subfamily 4, group A, member 3)
Type: protein-coding
Summary: This gene encodes a member of the NR4A subfamily of nuclear hormone receptors that bind to DNA and modulate gene expression. The encoded protein has been implicated in T and B lymphocyte apoptosis, and immune cell proliferation. Mice lacking the encoded protein exhibit partial bidirectional circling behavior and inner ear dysfunction. Disruption of this gene in mice also results in defective hippocampal axonal growth and postnatal neuronal cell death. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015].
Gene Ontology: BP: adult behavior, axon guidance, cellular respiration, cellular response to catecholamine stimulus, cellular response to corticotropin-releasing hormone stimulus, cellular response to leptin stimulus, common myeloid progenitor cell proliferation, energy homeostasis, fat cell differentiation, gastrulation, hippocampus development, inner ear morphogenesis, intracellular receptor signaling pathway, intracellular signal transduction, mast cell degranulation, mesoderm formation, negative regulation of neuron apoptotic process, negative regulation of smooth muscle cell apoptotic process, negative regulation of transcription by RNA polymerase II, neuromuscular process controlling balance, platelet-derived growth factor receptor signaling pathway, positive regulation of D-glucose transmembrane transport, positive regulation of DNA-templated transcription, positive regulation of cardiac muscle hypertrophy, positive regulation of cell cycle, positive regulation of dendritic cell apoptotic process, positive regulation of epithelial cell proliferation, positive regulation of feeding behavior, positive regulation of mast cell activation by Fc-epsilon receptor signaling pathway, positive regulation of mast cell cytokine production, positive regulation of monocyte aggregation, positive regulation of smooth muscle cell proliferation, positive regulation of transcription by RNA polymerase II, positive regulation of vascular associated smooth muscle cell migration, positive regulation of vascular associated smooth muscle cell proliferation, regulation of DNA-templated transcription, regulation of apoptotic process, regulation of smooth muscle cell proliferation, regulation of transcription by RNA polymerase II, regulation of type B pancreatic cell proliferation, response to hydrogen peroxide, semicircular canal morphogenesis, vestibular reflex; MF: DNA binding, DNA-binding transcription activator activity, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, cAMP response element binding, double-stranded DNA binding, histone acetyltransferase binding, metal ion binding, nuclear glucocorticoid receptor binding, nuclear receptor activity, protein homodimerization activity, protein kinase binding, sequence-specific DNA binding, transcription coactivator binding, zinc ion binding; CC: nucleus, transcription regulator complex
Pathways: Gene expression (Transcription), Generic Transcription Pathway, Nuclear Receptor transcription pathway, RNA Polymerase II Transcription, Transcriptional misregulation in cancer - Mus musculus (mouse)
UniProt: Q9QZB6
Entrez ID: 18124
|
Does Knockout of Serpina10 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 2,170
|
Knockout
|
Serpina10
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Serpina10 (serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the large serpin family of proteins, and is also known as serpin PZ-dependent protease inhibitor (ZPI or PZI). This protein is thought to play an important role in the regulation of coagulation. It directly inhibits factor XIa, and also inhibits factor Xa in the presence of calcium, phospholipids, and protein Z (PZ). Deficiencies in this gene lead to an increase in thrombosis. Alternative splicing results in multiple transcript variants that encode multiple protein isoforms. [provided by RefSeq, Aug 2014].
Gene Ontology: BP: blood coagulation, hemostasis, liver regeneration; MF: heparin binding, peptidase inhibitor activity, serine-type endopeptidase inhibitor activity; CC: extracellular region, extracellular space
Pathways: Metabolism of proteins, Post-translational protein modification, Post-translational protein phosphorylation, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
UniProt: Q8R121
Entrez ID: 217847
|
Does Knockout of Slc37a3 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,277
|
Knockout
|
Slc37a3
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Slc37a3 (solute carrier family 37 (glycerol-3-phosphate transporter), member 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: transmembrane transport, xenobiotic transmembrane transport; MF: protein binding, transmembrane transporter activity, xenobiotic transmembrane transporter activity; CC: endoplasmic reticulum, endoplasmic reticulum membrane, lysosomal membrane, lysosome, membrane
Pathways:
UniProt: Q3TIT8
Entrez ID: 72144
|
Does Knockout of Lce1i in Microglial Cell Line causally result in protein/peptide accumulation?
| 0
| 1,399
|
Knockout
|
Lce1i
|
protein/peptide accumulation
|
Microglial Cell Line
|
Gene: Lce1i (late cornified envelope 1I)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, epidermis development, keratinization; MF: identical protein binding, molecular_function
Pathways:
UniProt: Q9D6P5
Entrez ID: 76585
|
Does Knockout of Ltc4s in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,281
|
Knockout
|
Ltc4s
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Ltc4s (leukotriene C4 synthase)
Type: protein-coding
Summary: The protein encoded by this gene is an enzyme that catalyzes the synthesis of leukotriene C4 by combining leukotriene A4 with reduced glutathione. The encoded protein is found in the outer nuclear membrane and in the peripheral endoplasmic reticulum. Leukotrienes have been implicated as mediators of anaphylaxis and inflammatory conditions such as bronchial asthma in humans. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Sep 2015].
Gene Ontology: BP: cellular oxidant detoxification, leukotriene biosynthetic process, leukotriene metabolic process, lipid metabolic process, long-chain fatty acid biosynthetic process; MF: enzyme activator activity, glutathione binding, glutathione peroxidase activity, glutathione transferase activity, identical protein binding, leukotriene-C4 synthase activity, lipid binding, lyase activity, protein-containing complex binding, transferase activity; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane, nuclear envelope, nuclear membrane, nuclear outer membrane, nucleus
Pathways: Arachidonate metabolism, Arachidonic acid metabolism - Mus musculus (mouse), Biosynthesis of DHA-derived SPMs, Biosynthesis of DHA-derived sulfido conjugates, Biosynthesis of Lipoxins (LX), Biosynthesis of maresin conjugates in tissue regeneration (MCTR), Biosynthesis of protectin and resolvin conjugates in tissue regeneration (PCTR and RCTR), Biosynthesis of specialized proresolving mediators (SPMs), Fatty acid metabolism, Metabolism, Metabolism of lipids, Synthesis of 5-eicosatetraenoic acids, Synthesis of Leukotrienes (LT) and Eoxins (EX)
UniProt: Q60860
Entrez ID: 17001
|
Does Knockout of Onecut3 in Microglial Cell Line causally result in protein/peptide accumulation?
| 0
| 1,398
|
Knockout
|
Onecut3
|
protein/peptide accumulation
|
Microglial Cell Line
|
Gene: Onecut3 (one cut domain, family member 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: positive regulation of transcription by RNA polymerase II, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, sequence-specific double-stranded DNA binding; CC: cytosol, nucleus, transcription regulator complex
Pathways:
UniProt: Q8K557
Entrez ID: 246086
|
Does Knockout of Pip4k2b in Microglial Cell Line causally result in protein/peptide accumulation?
| 0
| 1,398
|
Knockout
|
Pip4k2b
|
protein/peptide accumulation
|
Microglial Cell Line
|
Gene: Pip4k2b (phosphatidylinositol-5-phosphate 4-kinase, type II, beta)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process, autophagosome-lysosome fusion, lipid metabolic process, negative regulation of insulin receptor signaling pathway, phosphatidylinositol metabolic process, phosphatidylinositol phosphate biosynthetic process, positive regulation of autophagosome assembly, regulation of autophagy; MF: 1-phosphatidylinositol-4-phosphate 5-kinase activity, 1-phosphatidylinositol-5-phosphate 4-kinase activity, ATP binding, GTP binding, kinase activity, nucleotide binding, phosphatidylinositol kinase activity, protein binding, protein homodimerization activity, transferase activity; CC: autophagosome, cytoplasm, endoplasmic reticulum, endoplasmic reticulum membrane, membrane, nucleoplasm, nucleus, plasma membrane
Pathways: D-<i>myo</i>-inositol (1,4,5)-trisphosphate biosynthesis, D-<i>myo</i>-inositol-5-phosphate metabolism, Gene expression (Transcription), Generic Transcription Pathway, Inositol phosphate metabolism - Mus musculus (mouse), Intracellular signaling by second messengers, Metabolism, Metabolism of lipids, Negative regulation of the PI3K/AKT network, PI Metabolism, PI5P Regulates TP53 Acetylation, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling, PIP metabolism, PIP3 activates AKT signaling, Phosphatidylinositol signaling system - Mus musculus (mouse), Phospholipid metabolism, RNA Polymerase II Transcription, Regulation of TP53 Activity, Regulation of TP53 Activity through Acetylation, Regulation of actin cytoskeleton - Mus musculus (mouse), Signal Transduction, Synthesis of PIPs at the plasma membrane, Synthesis of PIPs in the nucleus, Transcriptional Regulation by TP53
UniProt: Q80XI4
Entrez ID: 108083
|
Does Knockout of Vdr in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,276
|
Knockout
|
Vdr
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Vdr (vitamin D (1,25-dihydroxyvitamin D3) receptor)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: animal organ morphogenesis, apoptotic signaling pathway, calcium ion transport, cell differentiation, cell morphogenesis, cell-cell junction maintenance, decidualization, intestinal absorption, intracellular calcium ion homeostasis, intracellular receptor signaling pathway, lactation, mRNA transcription by RNA polymerase II, mammary gland branching involved in pregnancy, negative regulation of DNA-templated transcription, negative regulation of bone trabecula formation, negative regulation of cell population proliferation, negative regulation of keratinocyte proliferation, negative regulation of ossification, negative regulation of phosphate transmembrane transport, negative regulation of transcription by RNA polymerase II, nuclear receptor-mediated bile acid signaling pathway, nuclear receptor-mediated steroid hormone signaling pathway, phosphate ion transmembrane transport, positive regulation of apoptotic process involved in mammary gland involution, positive regulation of bone mineralization, positive regulation of gene expression, positive regulation of keratinocyte differentiation, positive regulation of parathyroid hormone secretion, positive regulation of transcription by RNA polymerase II, positive regulation of vitamin D receptor signaling pathway, regulation of DNA-templated transcription, regulation of calcium ion transport, response to bile acid, retinoic acid receptor signaling pathway, skeletal system development, vitamin D receptor signaling pathway; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II cis-regulatory region sequence-specific DNA binding, bile acid nuclear receptor activity, calcitriol binding, lithocholic acid binding, metal ion binding, nuclear receptor activity, nuclear retinoid X receptor binding, nuclear steroid receptor activity, protein binding, sequence-specific DNA binding, vitamin D binding, vitamin D response element binding, zinc ion binding; CC: RNA polymerase II transcription regulator complex, T-tubule, caveola, chromatin, cytoplasm, cytosol, dense fibrillar component, euchromatin, heterochromatin, nuclear matrix, nucleoplasm, nucleus, perinuclear region of cytoplasm, receptor complex
Pathways: Chemical carcinogenesis - receptor activation - Mus musculus (mouse), Endocrine and other factor-regulated calcium reabsorption - Mus musculus (mouse), Gene expression (Transcription), Generic Transcription Pathway, Metabolism, Metabolism of lipids, Metabolism of proteins, Metabolism of steroids, Mineral absorption - Mus musculus (mouse), Nuclear Receptor transcription pathway, Parathyroid hormone synthesis, secretion and action - Mus musculus (mouse), Post-translational protein modification, RNA Polymerase II Transcription, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of intracellular receptors, Tuberculosis - Mus musculus (mouse), Vitamin D (calciferol) metabolism
UniProt: P48281
Entrez ID: 22337
|
Does Knockout of Calr in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,683
|
Knockout
|
Calr
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Calr (calreticulin)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ERAD pathway, cardiac muscle cell differentiation, cellular response to electrical stimulus, cellular response to lithium ion, cellular response to virus, cellular senescence, cortical actin cytoskeleton organization, negative regulation of DNA-templated transcription, negative regulation of intracellular steroid hormone receptor signaling pathway, negative regulation of neuron differentiation, negative regulation of retinoic acid receptor signaling pathway, negative regulation of transcription by RNA polymerase II, negative regulation of translation, negative regulation of trophoblast cell migration, peptide antigen assembly with MHC class I protein complex, positive regulation of cell cycle, positive regulation of cell population proliferation, positive regulation of dendritic cell chemotaxis, positive regulation of endothelial cell migration, positive regulation of gene expression, positive regulation of non-canonical NF-kappaB signal transduction, positive regulation of phagocytosis, positive regulation of substrate adhesion-dependent cell spreading, protein export from nucleus, protein folding, protein localization to nucleus, protein maturation, protein stabilization, regulation of meiotic nuclear division, response to biphenyl, response to estradiol, response to glycoside, response to peptide, response to testosterone, response to xenobiotic stimulus, spermatogenesis; MF: calcium ion binding, carbohydrate binding, complement component C1q complex binding, hormone binding, integrin binding, iron ion binding, mRNA binding, metal ion binding, molecular sequestering activity, nuclear androgen receptor binding, nuclear export signal receptor activity, peptide binding, protein binding, protein folding chaperone, ubiquitin protein ligase binding, unfolded protein binding; CC: MHC class I peptide loading complex, acrosomal vesicle, cell surface, cortical granule, cytolytic granule, cytoplasm, cytoplasmic vesicle, cytosol, endomembrane system, endoplasmic reticulum, endoplasmic reticulum lumen, endoplasmic reticulum membrane, endoplasmic reticulum quality control compartment, external side of plasma membrane, extracellular matrix, extracellular region, extracellular space, glutamatergic synapse, lysosome, membrane, mitochondrion, nuclear envelope, nucleus, perinuclear region of cytoplasm, phagocytic vesicle, postsynapse, protein-containing complex, ribosome, sarcoplasmic reticulum, sarcoplasmic reticulum lumen, smooth endoplasmic reticulum
Pathways: Adaptive Immune System, Antigen Presentation: Folding, assembly and peptide loading of class I MHC, Antigen processing and presentation - Mus musculus (mouse), Antigen processing-Cross presentation, Asparagine N-linked glycosylation, Binding and Uptake of Ligands by Scavenger Receptors, Calnexin/calreticulin cycle, Chagas disease - Mus musculus (mouse), Class I MHC mediated antigen processing & presentation, ER-Phagosome pathway, Epstein-Barr virus infection - Mus musculus (mouse), Herpes simplex virus 1 infection - Mus musculus (mouse), Human T-cell leukemia virus 1 infection - Mus musculus (mouse), Human cytomegalovirus infection - Mus musculus (mouse), Human immunodeficiency virus 1 infection - Mus musculus (mouse), Immune System, Metabolism of proteins, N-glycan trimming in the ER and Calnexin/Calreticulin cycle, Phagosome - Mus musculus (mouse), Post-translational protein modification, Protein processing in endoplasmic reticulum - Mus musculus (mouse), Scavenging by Class A Receptors, Vesicle-mediated transport
UniProt: P14211
Entrez ID: 12317
|
Does Knockout of Sertad2 in Neuroblastoma Cell Line causally result in response to virus?
| 0
| 1,422
|
Knockout
|
Sertad2
|
response to virus
|
Neuroblastoma Cell Line
|
Gene: Sertad2 (SERTA domain containing 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of cell growth, positive regulation of DNA-templated transcription; MF: protein binding, transcription coactivator activity; CC: cytoplasm, cytosol, nucleoplasm, nucleus
Pathways:
UniProt: Q9JJG5
Entrez ID: 58172
|
Does Knockout of Wrn in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,679
|
Knockout
|
Wrn
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Wrn (Werner syndrome RecQ like helicase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA geometric change, DNA metabolic process, DNA recombination, DNA repair, DNA replication, DNA synthesis involved in DNA repair, base-excision repair, cellular response to gamma radiation, cellular response to starvation, cellular senescence, determination of adult lifespan, double-strand break repair, double-strand break repair via homologous recombination, mismatch repair, nucleobase-containing compound metabolic process, positive regulation of strand invasion, protein localization to nucleolus, regulation of apoptotic process, regulation of growth rate, replication fork processing, replicative senescence, response to UV-C, response to oxidative stress, telomere maintenance, telomeric D-loop disassembly; MF: 3'-5' DNA helicase activity, 3'-5' exonuclease activity, 3'-flap-structured DNA binding, 8-hydroxy-2'-deoxyguanosine DNA binding, ATP binding, ATP hydrolysis activity, DNA binding, DNA helicase activity, G-quadruplex DNA binding, MutLalpha complex binding, Y-form DNA binding, bubble DNA binding, catalytic activity, chromatin binding, exonuclease activity, forked DNA-dependent helicase activity, four-way junction DNA binding, four-way junction helicase activity, helicase activity, hydrolase activity, isomerase activity, magnesium ion binding, manganese ion binding, metal ion binding, nuclease activity, nucleic acid binding, nucleotide binding, protein binding, protein homodimerization activity, protein-containing complex binding, telomeric D-loop binding, telomeric G-quadruplex DNA binding; CC: centrosome, chromosome, chromosome, telomeric region, cytoplasm, nuclear speck, nucleolus, nucleoplasm, nucleus, replication fork
Pathways: Cell Cycle, Cell Cycle Checkpoints, Chromosome Maintenance, DNA Double-Strand Break Repair, DNA Repair, Extension of Telomeres, G2/M Checkpoints, G2/M DNA damage checkpoint, Gene expression (Transcription), Generic Transcription Pathway, HDR through Homologous Recombination (HRR), HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), HDR through Single Strand Annealing (SSA), Homologous DNA Pairing and Strand Exchange, Homology Directed Repair, Presynaptic phase of homologous DNA pairing and strand exchange, Processing of DNA double-strand break ends, Processive synthesis on the C-strand of the telomere, RNA Polymerase II Transcription, Regulation of TP53 Activity, Regulation of TP53 Activity through Phosphorylation, Removal of the Flap Intermediate from the C-strand, Resolution of D-Loop Structures, Resolution of D-loop Structures through Holliday Junction Intermediates, Telomere C-strand (Lagging Strand) Synthesis, Telomere Maintenance, Transcriptional Regulation by TP53
UniProt: O09053
Entrez ID: 22427
|
Does Knockout of Bzw2 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,276
|
Knockout
|
Bzw2
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Bzw2 (basic leucine zipper and W2 domains 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: regulation of translation, regulation of translational initiation; CC: cytoplasm
Pathways:
UniProt: Q91VK1
Entrez ID: 66912
|
Does Knockout of Btnl10 in Mouse cell causally result in protein/peptide accumulation?
| 0
| 1,047
|
Knockout
|
Btnl10
|
protein/peptide accumulation
|
Mouse cell
|
Gene: Btnl10 (butyrophilin-like 10)
Type: protein-coding
Summary: Predicted to enable signaling receptor binding activity. Predicted to be involved in T cell receptor signaling pathway and regulation of cytokine production. Predicted to be located in membrane. Predicted to be active in external side of plasma membrane. Is expressed in liver lobe. Orthologous to human BTNL10P (butyrophilin like 10, pseudogene). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: T cell receptor signaling pathway, regulation of cytokine production; CC: external side of plasma membrane, membrane
Pathways:
UniProt: Q9JK39
Entrez ID: 192194
|
Does Knockout of Usp26 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,288
|
Knockout
|
Usp26
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Usp26 (ubiquitin specific peptidase 26)
Type: protein-coding
Summary: Predicted to enable K48-linked deubiquitinase activity and cysteine-type deubiquitinase activity. Involved in negative regulation of proteasomal ubiquitin-dependent protein catabolic process. Predicted to be located in nucleoplasm and sperm flagellum. Predicted to be active in cytosol and nucleus. Is expressed in testis. Human ortholog(s) of this gene implicated in X-linked spermatogenic failure 6. Orthologous to human USP26 (ubiquitin specific peptidase 26). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: G1/S transition of mitotic cell cycle, negative regulation of proteasomal ubiquitin-dependent protein catabolic process, protein deubiquitination, proteolysis, regulation of androgen receptor signaling pathway, regulation of protein stability, spermatogenesis; MF: K48-linked deubiquitinase activity, cysteine-type deubiquitinase activity, cysteine-type peptidase activity, deubiquitinase activity, hydrolase activity, peptidase activity; CC: cell projection, cilium, cytoplasm, cytoskeleton, cytosol, motile cilium, nucleoplasm, nucleus, sperm flagellum
Pathways: Deubiquitination, Metabolism of proteins, Post-translational protein modification, Ub-specific processing proteases
UniProt: Q99MX1
Entrez ID: 83563
|
Does Knockout of Retnla in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 1,130
|
Knockout
|
Retnla
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Retnla (resistin like alpha)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: response to nematode, response to selenium ion, signal transduction; CC: extracellular region, extracellular space
Pathways:
UniProt: Q9EP95
Entrez ID: 57262
|
Does Knockout of Zfp275 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,268
|
Knockout
|
Zfp275
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Zfp275 (zinc finger protein 275)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II transcription regulatory region sequence-specific DNA binding, metal ion binding, zinc ion binding; CC: nucleus
Pathways: Herpes simplex virus 1 infection - Mus musculus (mouse)
UniProt: Q3UQ14, A2AIE7, G3X904
Entrez ID: 27081
|
Does Knockout of Chrm4 in Embryonic Fibroblast Cell Line causally result in cell proliferation?
| 0
| 345
|
Knockout
|
Chrm4
|
cell proliferation
|
Embryonic Fibroblast Cell Line
|
Gene: Chrm4 (cholinergic receptor, muscarinic 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger, adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway, chemical synaptic transmission, regulation of locomotion, signal transduction; MF: G protein-coupled acetylcholine receptor activity, G protein-coupled receptor activity, guanyl-nucleotide exchange factor activity; CC: asymmetric synapse, axon terminus, dendrite, glutamatergic synapse, membrane, neuronal cell body, plasma membrane, postsynaptic density membrane, postsynaptic membrane, presynaptic membrane, sarcolemma, synapse
Pathways: Amine ligand-binding receptors, Cholinergic synapse - Mus musculus (mouse), Class A/1 (Rhodopsin-like receptors), G alpha (i) signalling events, GPCR downstream signalling, GPCR ligand binding, Muscarinic acetylcholine receptors, Neuroactive ligand-receptor interaction - Mus musculus (mouse), Regulation of actin cytoskeleton - Mus musculus (mouse), Signal Transduction, Signaling by GPCR
UniProt: P32211
Entrez ID: 12672
|
Does Knockout of Ctxn1 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 579
|
Knockout
|
Ctxn1
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Ctxn1 (cortexin 1)
Type: protein-coding
Summary: Predicted to be located in membrane. Is expressed in several structures, including central nervous system; gut; nose; retina; and trigeminal nerve. Orthologous to human CTXN1 (cortexin 1). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: CC: cellular_component, membrane
Pathways:
UniProt: Q8K129
Entrez ID: 330695
|
Does Knockout of Mbp in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,286
|
Knockout
|
Mbp
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Mbp (myelin basic protein)
Type: protein-coding
Summary: The protein encoded by the classic Mbp gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. However, Mbp-related transcripts are also present in the bone marrow and the immune system. These mRNAs arise from the long Mbp gene (otherwise called 'Golli-Mbp') that contains 3 additional exons located upstream of the classic Mbp exons. Alternative splicing from the Golli and the Mbp transcription start sites gives rise to 2 sets of Mbp-related transcripts and gene products. The Golli mRNAs contain 3 exons unique to Golli-Mbp, spliced in-frame to 1 or more Mbp exons. They encode hybrid proteins that have N-terminal Golli aa sequence linked to Mbp aa sequence. The second family of transcripts contain only Mbp exons and produce the well characterized myelin basic proteins. This complex gene structure is conserved among species suggesting that the Mbp transcription unit is an integral part of the Golli transcription unit and that this arrangement is important for the function and/or regulation of these genes. Mutation of the Mbp gene is associated with the 'shiverer' and 'myelin deficient' phenotypes in mouse. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: MAPK cascade, maintenance of blood-brain barrier, membrane organization, myelination, negative regulation of axonogenesis, negative regulation of heterotypic cell-cell adhesion, positive regulation of chemokine (C-X-C motif) ligand 2 production, positive regulation of interleukin-6 production, response to progesterone, response to toxic substance, sensory perception of sound; MF: calmodulin binding, lipid binding, protease binding, structural constituent of myelin sheath; CC: cell periphery, cell projection, cell surface, compact myelin, cytoplasm, internode region of axon, membrane, myelin sheath, neuronal cell body, nucleus, plasma membrane, protein-containing complex
Pathways:
UniProt: P04370
Entrez ID: 17196
|
Does Knockout of Arxes2 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,682
|
Knockout
|
Arxes2
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Arxes2 (adipocyte-related X-chromosome expressed sequence 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: fat cell differentiation, protein targeting to ER, signal peptide processing; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane, signal peptidase complex
Pathways: Protein export - Mus musculus (mouse)
UniProt: C0HK80
Entrez ID: 76976
|
Does Knockout of Eng in Microglial Cell Line causally result in protein/peptide accumulation?
| 0
| 1,399
|
Knockout
|
Eng
|
protein/peptide accumulation
|
Microglial Cell Line
|
Gene: Eng (endoglin)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: angiogenesis, artery morphogenesis, atrial cardiac muscle tissue morphogenesis, atrioventricular canal morphogenesis, branching involved in blood vessel morphogenesis, cardiac atrium morphogenesis, cardiac jelly development, cardiac ventricle morphogenesis, cell adhesion, cell chemotaxis, cell migration, cell migration involved in endocardial cushion formation, cell motility, central nervous system vasculogenesis, detection of hypoxia, dorsal aorta morphogenesis, endocardial cushion morphogenesis, endocardial cushion to mesenchymal transition, epithelial to mesenchymal transition involved in endocardial cushion formation, extracellular matrix constituent secretion, extracellular matrix disassembly, heart development, heart looping, negative regulation of SMAD protein signal transduction, negative regulation of cell migration, negative regulation of endothelial cell proliferation, negative regulation of gene expression, negative regulation of transcription by RNA polymerase II, outflow tract septum morphogenesis, positive regulation of BMP signaling pathway, positive regulation of SMAD protein signal transduction, positive regulation of angiogenesis, positive regulation of collagen biosynthetic process, positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation, positive regulation of gene expression, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, positive regulation of systemic arterial blood pressure, positive regulation of transcription by RNA polymerase II, positive regulation of vascular associated smooth muscle cell differentiation, regulation of DNA-templated transcription, regulation of cardiac muscle cell apoptotic process, regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis, regulation of cell proliferation involved in heart morphogenesis, regulation of transforming growth factor beta receptor signaling pathway, response to hypoxia, smooth muscle tissue development, sprouting angiogenesis, transforming growth factor beta receptor signaling pathway, vascular associated smooth muscle cell development, vasculogenesis, venous blood vessel morphogenesis, ventricular trabecula myocardium morphogenesis, wound healing; MF: BMP binding, coreceptor activity, galactose binding, glycosaminoglycan binding, identical protein binding, protein binding, protein homodimerization activity, signaling receptor activator activity, transforming growth factor beta binding, type I transforming growth factor beta receptor binding, type II transforming growth factor beta receptor binding; CC: cell surface, endothelial microparticle, external side of plasma membrane, extracellular space, membrane, nuclear body, plasma membrane, receptor complex
Pathways:
UniProt: Q63961
Entrez ID: 13805
|
Does Knockout of Ces1a in Pancreatic Cancer Cell Line causally result in response to chemicals?
| 0
| 2,359
|
Knockout
|
Ces1a
|
response to chemicals
|
Pancreatic Cancer Cell Line
|
Gene: Ces1a (carboxylesterase 1A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to cholesterol, cellular response to low-density lipoprotein particle stimulus, cholesterol biosynthetic process, cholesterol homeostasis, cholesterol metabolic process, epithelial cell differentiation, lipid catabolic process, medium-chain fatty acid metabolic process, negative regulation of cholesterol storage, positive regulation of cholesterol efflux, positive regulation of cholesterol metabolic process, regulation of bile acid biosynthetic process, regulation of bile acid secretion, reverse cholesterol transport; MF: carboxylesterase activity, carboxylic ester hydrolase activity, hydrolase activity, sterol ester esterase activity; CC: cytoplasm, endoplasmic reticulum, lipid droplet
Pathways:
UniProt: Q5FWH4, E9PYP1
Entrez ID: 244595
|
Does Knockout of Mlxipl in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 81
|
Knockout
|
Mlxipl
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Mlxipl (MLX interacting protein-like)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to glucose stimulus, energy homeostasis, fatty acid homeostasis, glucose homeostasis, glucose mediated signaling pathway, lipid biosynthetic process, negative regulation of DNA-templated transcription, negative regulation of oxidative phosphorylation, negative regulation of signal transduction by p53 class mediator, negative regulation of transcription by RNA polymerase II, positive regulation of DNA-templated transcription, positive regulation of cell population proliferation, positive regulation of fatty acid biosynthetic process, positive regulation of glycolytic process, positive regulation of insulin secretion involved in cellular response to glucose stimulus, positive regulation of lipid biosynthetic process, positive regulation of transcription by RNA polymerase II, positive regulation of transcription from RNA polymerase II promoter by glucose, regulation of glycolytic process, regulation of transcription by RNA polymerase II, response to glucose; MF: DNA binding, DNA-binding transcription activator activity, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription factor binding, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II-specific DNA-binding transcription factor binding, carbohydrate response element binding, protein binding, protein dimerization activity, protein heterodimerization activity, protein kinase binding, sequence-specific DNA binding; CC: RNA polymerase II transcription regulator complex, chromatin, cytoplasm, cytosol, nucleoplasm, nucleus, transcription regulator complex
Pathways: Insulin resistance - Mus musculus (mouse), Non-alcoholic fatty liver disease - Mus musculus (mouse)
UniProt: Q99MZ3
Entrez ID: 58805
|
Does Knockout of Arpc1a in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,279
|
Knockout
|
Arpc1a
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Arpc1a (actin related protein 2/3 complex, subunit 1A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Arp2/3 complex-mediated actin nucleation; MF: actin binding, actin filament binding, protein binding; CC: Arp2/3 protein complex, actin cytoskeleton, cytoplasm, cytoskeleton, glutamatergic synapse, muscle cell projection membrane, nucleus, site of double-strand break, synapse
Pathways: Axon guidance, Bacterial invasion of epithelial cells - Mus musculus (mouse), Clathrin-mediated endocytosis, Developmental Biology, EPH-Ephrin signaling, EPHB-mediated forward signaling, Endocytosis - Mus musculus (mouse), Fc gamma R-mediated phagocytosis - Mus musculus (mouse), Fcgamma receptor (FCGR) dependent phagocytosis, Immune System, Innate Immune System, Membrane Trafficking, Nervous system development, RHO GTPase Effectors, RHO GTPases Activate WASPs and WAVEs, Regulation of actin cytoskeleton - Mus musculus (mouse), Regulation of actin dynamics for phagocytic cup formation, Salmonella infection - Mus musculus (mouse), Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Tight junction - Mus musculus (mouse), Vesicle-mediated transport, Yersinia infection - Mus musculus (mouse)
UniProt: Q9R0Q6
Entrez ID: 56443
|
Does Knockout of Coro2b in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,682
|
Knockout
|
Coro2b
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Coro2b (coronin, actin binding protein, 2B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: focal adhesion assembly, negative regulation of cell-substrate adhesion, negative regulation of establishment of protein localization, negative regulation of stress fiber assembly, positive regulation of establishment of protein localization, regulation of actin cytoskeleton organization, regulation of cellular response to stress, regulation of glomerular filtration; MF: actin binding, actin filament binding, talin binding, vinculin binding; CC: cytoplasm, cytoskeleton, focal adhesion, stress fiber
Pathways:
UniProt: Q8BH44
Entrez ID: 235431
|
Does Knockout of Wscd1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,287
|
Knockout
|
Wscd1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Wscd1 (WSC domain containing 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: molecular_function, sulfotransferase activity; CC: Golgi apparatus, Golgi membrane, cellular_component, membrane
Pathways:
UniProt: Q80XH4
Entrez ID: 216881
|
Does Knockout of Cpt2 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 2,170
|
Knockout
|
Cpt2
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Cpt2 (carnitine palmitoyltransferase 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: carnitine metabolic process, carnitine shuttle, fatty acid beta-oxidation, fatty acid metabolic process, in utero embryonic development, lipid metabolic process, long-chain fatty acid metabolic process, positive regulation of cold-induced thermogenesis; MF: acyltransferase activity, carnitine O-octanoyltransferase activity, carnitine O-palmitoyltransferase activity, transferase activity; CC: membrane, mitochondrial inner membrane, mitochondrial matrix, mitochondrion, nucleolus, nucleoplasm
Pathways: Carnitine shuttle, Diabetic cardiomyopathy - Mus musculus (mouse), Fatty acid degradation - Mus musculus (mouse), Fatty acid metabolism, Metabolism, Metabolism of lipids, PPAR signaling pathway - Mus musculus (mouse), Thermogenesis - Mus musculus (mouse)
UniProt: P52825
Entrez ID: 12896
|
Does Knockout of Mtx1 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 2,179
|
Knockout
|
Mtx1
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Mtx1 (metaxin 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrion organization, protein transport; CC: SAM complex, membrane, mitochondrial inner membrane, mitochondrial outer membrane, mitochondrion
Pathways:
UniProt: D3Z3F4, Q8R5C0, A0A6I8MWZ8, D3YVW0, G3UYJ5, G3UXB5, G3UXX9, G3UXP6, G3XA66, G3XA75
Entrez ID: 17827
|
Does Knockout of Gzmn in Embryonic Fibroblast Cell Line causally result in cell proliferation?
| 0
| 345
|
Knockout
|
Gzmn
|
cell proliferation
|
Embryonic Fibroblast Cell Line
|
Gene: Gzmn (granzyme N)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: protein maturation, proteolysis; MF: hydrolase activity, peptidase activity, serine-type endopeptidase activity, serine-type peptidase activity; CC: cytolytic granule, cytoplasm, extracellular space
Pathways:
UniProt: Q920S1, Q76HN3
Entrez ID: 245839
|
Does Knockout of Ube3a in Mouse kidney carcinoma cell causally result in cell proliferation?
| 1
| 1,286
|
Knockout
|
Ube3a
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Ube3a (ubiquitin protein ligase E3A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: androgen receptor signaling pathway, animal organ development, cellular response to nutrient levels, locomotory exploration behavior, modulation of chemical synaptic transmission, motor learning, negative regulation of TORC1 signaling, negative regulation of dendritic spine morphogenesis, nuclear receptor-mediated steroid hormone signaling pathway, ovarian follicle development, positive regulation of Golgi lumen acidification, positive regulation of TORC1 signaling, positive regulation of macromolecule metabolic process, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, positive regulation of protein localization to lysosome, positive regulation of protein ubiquitination, positive regulation of transcription by RNA polymerase II, progesterone receptor signaling pathway, prostate gland growth, proteasome-mediated ubiquitin-dependent protein catabolic process, protein K48-linked ubiquitination, protein autoubiquitination, protein polyubiquitination, protein ubiquitination, regulation of circadian rhythm, regulation of primary metabolic process, regulation of synaptic plasticity, regulation of ubiquitin-dependent protein catabolic process, response to progesterone, rhythmic process, sperm entry, system development, ubiquitin-dependent protein catabolic process; MF: metal ion binding, protein binding, transcription coactivator activity, transferase activity, ubiquitin protein ligase activity, ubiquitin-protein transferase activity, zinc ion binding; CC: cytoplasm, cytosol, glutamatergic synapse, nucleus, postsynaptic cytosol, proteasome complex, synaptic vesicle
Pathways: Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Class I MHC mediated antigen processing & presentation, Human papillomavirus infection - Mus musculus (mouse), Immune System, Targeted protein degradation, Ubiquitin mediated proteolysis - Mus musculus (mouse), Viral carcinogenesis - Mus musculus (mouse)
UniProt: O08759
Entrez ID: 22215
|
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