prompt
string | hit
int64 | screen_id
int64 | crispr_strategy
string | gene
string | phenotype
string | cell_type
string | gene_context
string |
|---|---|---|---|---|---|---|---|
Does Knockout of Vmn2r20 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,684
|
Knockout
|
Vmn2r20
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Vmn2r20 (vomeronasal 2, receptor 20)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, regulation of calcium ion transport, signal transduction; MF: G protein-coupled receptor activity; CC: membrane, plasma membrane
Pathways:
UniProt: A0A3B2WD50, L7N2B1
Entrez ID: 667180
|
Does Knockout of Best3 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 165
|
Knockout
|
Best3
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Best3 (bestrophin 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chloride transmembrane transport, chloride transport, inorganic anion transport, monoatomic anion transmembrane transport, monoatomic ion transmembrane transport, monoatomic ion transport, negative regulation of monoatomic ion transport; MF: channel activity, chloride channel activity, intracellularly calcium-gated chloride channel activity, ligand-gated monoatomic anion channel activity, metal ion binding; CC: chloride channel complex, membrane, plasma membrane
Pathways: Ion channel transport, Stimuli-sensing channels, Transport of small molecules
UniProt: Q6H1V1
Entrez ID: 382427
|
Does Knockout of Sfswap in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,288
|
Knockout
|
Sfswap
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Sfswap (splicing factor SWAP)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA processing, RNA splicing, alternative mRNA splicing, via spliceosome, mRNA 5'-splice site recognition, mRNA processing, negative regulation of mRNA splicing, via spliceosome; MF: RNA binding, protein binding
Pathways:
UniProt: Q3USH5
Entrez ID: 231769
|
Does Knockout of Lrrc55 in Immortal mouse chromaffin cells causally result in cell viability?
| 1
| 2,469
|
Knockout
|
Lrrc55
|
cell viability
|
Immortal mouse chromaffin cells
|
Gene: Lrrc55 (leucine rich repeat containing 55)
Type: protein-coding
Summary: Predicted to enable potassium channel activator activity; transmembrane transporter binding activity; and voltage-gated potassium channel activity. Predicted to be involved in positive regulation of voltage-gated potassium channel activity and potassium ion transmembrane transport. Predicted to be located in plasma membrane. Predicted to be part of voltage-gated potassium channel complex. Orthologous to human LRRC55 (leucine rich repeat containing 55). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: monoatomic ion transmembrane transport, monoatomic ion transport, potassium ion transmembrane transport; MF: potassium channel activator activity, transmembrane transporter binding, voltage-gated potassium channel activity; CC: membrane, plasma membrane, voltage-gated potassium channel complex
Pathways:
UniProt: Q3UY51
Entrez ID: 241528
|
Does Knockout of Cacna1f in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,290
|
Knockout
|
Cacna1f
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Cacna1f (calcium channel, voltage-dependent, alpha 1F subunit)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: axonogenesis, calcium ion import across plasma membrane, calcium ion transmembrane transport, calcium ion transport, dendrite morphogenesis, detection of light stimulus involved in visual perception, gene expression, intracellular calcium ion homeostasis, monoatomic ion transmembrane transport, monoatomic ion transport, retina development in camera-type eye, transmembrane transport, visual perception; MF: calcium channel activity, high voltage-gated calcium channel activity, metal ion binding, monoatomic ion channel activity, voltage-gated calcium channel activity; CC: membrane, monoatomic ion channel complex, neuronal cell body, perikaryon, photoreceptor outer segment, plasma membrane, voltage-gated calcium channel complex
Pathways: Adrenergic signaling in cardiomyocytes - Mus musculus (mouse), Aldosterone synthesis and secretion - Mus musculus (mouse), Alzheimer disease - Mus musculus (mouse), Arrhythmogenic right ventricular cardiomyopathy - Mus musculus (mouse), Calcium signaling pathway - Mus musculus (mouse), Cardiac muscle contraction - Mus musculus (mouse), Chemical carcinogenesis - receptor activation - Mus musculus (mouse), Cholinergic synapse - Mus musculus (mouse), Cortisol synthesis and secretion - Mus musculus (mouse), Cushing syndrome - Mus musculus (mouse), Dilated cardiomyopathy - Mus musculus (mouse), GABAergic synapse - Mus musculus (mouse), GnRH secretion - Mus musculus (mouse), GnRH signaling pathway - Mus musculus (mouse), Growth hormone synthesis, secretion and action - Mus musculus (mouse), Hypertrophic cardiomyopathy - Mus musculus (mouse), Insulin secretion - Mus musculus (mouse), MAPK signaling pathway - Mus musculus (mouse), Oxytocin signaling pathway - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Prion disease - Mus musculus (mouse), Renin secretion - Mus musculus (mouse), Retrograde endocannabinoid signaling - Mus musculus (mouse), Serotonergic synapse - Mus musculus (mouse), Vascular smooth muscle contraction - Mus musculus (mouse), cAMP signaling pathway - Mus musculus (mouse), cGMP-PKG signaling pathway - Mus musculus (mouse)
UniProt: Q8C8Q4, Q7TNI3, B1AVA5, B1AVA4, B1AVA6, S4R182
Entrez ID: 54652
|
Does Knockout of Strn4 in Melanoma Cell Line causally result in cell proliferation?
| 1
| 1,157
|
Knockout
|
Strn4
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Strn4 (striatin, calmodulin binding protein 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, negative regulation of hippo signaling, regulation of modification of postsynaptic structure; MF: armadillo repeat domain binding, calmodulin binding, molecular_function, protein binding, protein domain specific binding, protein phosphatase 2A binding, protein-containing complex binding, protein-macromolecule adaptor activity; CC: FAR/SIN/STRIPAK complex, GABA-ergic synapse, cell projection, cytoplasm, dendrite, dendritic spine, glutamatergic synapse, membrane, neuronal cell body, postsynapse, protein-containing complex, synapse
Pathways:
UniProt: P58404
Entrez ID: 97387
|
Does Knockout of Fancl in Lymphoma Cell Line causally result in response to chemicals?
| 1
| 1,547
|
Knockout
|
Fancl
|
response to chemicals
|
Lymphoma Cell Line
|
Gene: Fancl (Fanconi anemia, complementation group L)
Type: protein-coding
Summary: This gene encodes the complementation group L subunit of the multimeric Fanconi anemia (FA) nuclear complex composed of proteins encoded by over ten Fanconi anemia complementation (FANC) group genes. The FA complex is necessary for protection against DNA damage. This gene product, an E3 ubiquitin ligase, catalyzes and is required for the monoubiquitination of the protein encoded by the Fanconi anemia, complementation group D2 gene, a critical step in the FA pathway (PMID: 12973351, 21229326). In mouse, mutations of this E3 ubiquitin ligase gene can lead to infertility in adult males and females, and a deletion of this gene can cause embryonic lethality in some genetic backgrounds. A pseudogene of this gene has been identified on chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013].
Gene Ontology: BP: DNA damage response, DNA repair, gamete generation, interstrand cross-link repair, protein monoubiquitination, protein ubiquitination, regulation of cell population proliferation; MF: metal ion binding, protein binding, transferase activity, ubiquitin protein ligase activity, ubiquitin protein ligase binding, ubiquitin-protein transferase activity, zinc ion binding; CC: Fanconi anaemia nuclear complex, chromatin, cytoplasm, nuclear body, nuclear envelope, nucleus
Pathways: Antiviral mechanism by IFN-stimulated genes, Cytokine Signaling in Immune system, DNA Repair, Fanconi Anemia Pathway, Fanconi anemia pathway - Mus musculus (mouse), Immune System, Interferon Signaling, PKR-mediated signaling, Ubiquitin mediated proteolysis - Mus musculus (mouse)
UniProt: Q9CR14
Entrez ID: 67030
|
Does Knockout of Ddrgk1 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 2,307
|
Knockout
|
Ddrgk1
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Ddrgk1 (DDRGK domain containing 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cartilage development, negative regulation of IRE1-mediated unfolded protein response, negative regulation of PERK-mediated unfolded protein response, negative regulation of apoptotic process, negative regulation of gene expression, negative regulation of proteasomal ubiquitin-dependent protein catabolic process, positive regulation of I-kappaB phosphorylation, positive regulation of NF-kappaB transcription factor activity, positive regulation of canonical NF-kappaB signal transduction, positive regulation of cell migration, positive regulation of cell population proliferation, positive regulation of gene expression, positive regulation of plasma cell differentiation, positive regulation of proteasomal protein catabolic process, positive regulation of proteasomal ubiquitin-dependent protein catabolic process, positive regulation of protein localization to endoplasmic reticulum, positive regulation of proteolysis involved in protein catabolic process, positive regulation of reticulophagy, positive regulation of transcription by RNA polymerase II, protein K69-linked ufmylation, protein localization to endoplasmic reticulum, protein ufmylation, regulation of intracellular estrogen receptor signaling pathway, regulation of protein stability, rescue of stalled ribosome, response to endoplasmic reticulum stress, reticulophagy, ribosome disassembly; MF: UFM1-modified protein reader activity, protein binding, ubiquitin-like protein ligase binding; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane, nucleolus
Pathways: RHO GTPase cycle, RHOA GTPase cycle, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q80WW9
Entrez ID: 77006
|
Does Knockout of Cnmd in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,289
|
Knockout
|
Cnmd
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Cnmd (chondromodulin)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cartilage development, cell differentiation, endothelial cell morphogenesis, negative regulation of angiogenesis, negative regulation of endothelial cell proliferation, negative regulation of vascular endothelial growth factor receptor signaling pathway; CC: endomembrane system, extracellular region, membrane
Pathways:
UniProt: Q9Z1F6
Entrez ID: 16840
|
Does Knockout of Dut in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Dut
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Dut (deoxyuridine triphosphatase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: dTMP biosynthetic process, dUMP biosynthetic process, dUTP catabolic process, nucleotide metabolic process, pyrimidine deoxyribonucleoside monophosphate biosynthetic process, pyrimidine deoxyribonucleotide biosynthetic process, regulation of protein-containing complex assembly; MF: dUTP diphosphatase activity, hydrolase activity, identical protein binding, magnesium ion binding, metal ion binding, peroxisome proliferator activated receptor binding, pyrimidine deoxyribonucleotide binding, signaling receptor inhibitor activity; CC: mitochondrion, nucleoplasm, nucleus
Pathways: Drug metabolism - other enzymes - Mus musculus (mouse), Interconversion of nucleotide di- and triphosphates, Metabolism, Metabolism of nucleotides, Pyrimidine metabolism - Mus musculus (mouse), pyrimidine deoxyribonucleotides <i>de novo</i> biosynthesis I
UniProt: Q9CQ43
Entrez ID: 110074
|
Does Knockout of Serac1 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 1
| 1,152
|
Knockout
|
Serac1
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Serac1 (serine active site containing 1)
Type: protein-coding
Summary: Acts upstream of or within extracellular matrix organization. Located in endoplasmic reticulum membrane; extracellular matrix; and mitochondrial outer membrane. Used to study 3-methylglutaconic aciduria with deafness, encephalopathy, and Leigh-like syndrome. Human ortholog(s) of this gene implicated in 3-methylglutaconic aciduria with deafness, encephalopathy, and Leigh-like syndrome. Orthologous to human SERAC1 (serine active site containing 1). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: extracellular matrix organization, intracellular cholesterol transport, lipid metabolic process, phosphatidylglycerol acyl-chain remodeling, phospholipid biosynthetic process; CC: endoplasmic reticulum, endoplasmic reticulum membrane, extracellular matrix, membrane, mitochondria-associated endoplasmic reticulum membrane contact site, mitochondrial membrane, mitochondrial outer membrane, mitochondrion
Pathways:
UniProt: Q3U213
Entrez ID: 321007
|
Does Knockout of Sec61b in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 81
|
Knockout
|
Sec61b
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Sec61b (SEC61 translocon subunit beta)
Type: protein-coding
Summary: Enables ribosome binding activity. Predicted to be involved in SRP-dependent cotranslational protein targeting to membrane, translocation; post-translational protein targeting to membrane, translocation; and retrograde protein transport, ER to cytosol. Located in endoplasmic reticulum quality control compartment. Orthologous to human SEC61B (SEC61 translocon subunit beta). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: ERAD pathway, SRP-dependent cotranslational protein targeting to membrane, translocation, intracellular protein transport, post-translational protein targeting to membrane, translocation, protein transport, retrograde protein transport, ER to cytosol; MF: epidermal growth factor binding, guanyl-nucleotide exchange factor activity, protein binding, ribosome binding; CC: Sec61 translocon complex, endoplasmic reticulum, endoplasmic reticulum membrane, endoplasmic reticulum quality control compartment, membrane
Pathways: Insertion of tail-anchored proteins into the endoplasmic reticulum membrane, Phagosome - Mus musculus (mouse), Protein export - Mus musculus (mouse), Protein localization, Protein processing in endoplasmic reticulum - Mus musculus (mouse)
UniProt: Q9CQS8
Entrez ID: 66212
|
Does Knockout of Lrp5 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,286
|
Knockout
|
Lrp5
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Lrp5 (low density lipoprotein receptor-related protein 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Norrin signaling pathway, Wnt signaling pathway, adipose tissue development, amino acid transport, anatomical structure regression, anterior/posterior pattern specification, apoptotic process involved in blood vessel morphogenesis, blood vessel morphogenesis, bone development, bone marrow development, bone morphogenesis, bone remodeling, branching involved in mammary gland duct morphogenesis, canonical Wnt signaling pathway, cell migration involved in gastrulation, cell-cell adhesion, cell-cell signaling involved in mammary gland development, cholesterol homeostasis, cholesterol metabolic process, embryonic digit morphogenesis, endocytosis, establishment of blood-brain barrier, establishment of blood-retinal barrier, extracellular matrix-cell signaling, gastrulation with mouth forming second, gene expression, glucose catabolic process, limb morphogenesis, mammary gland development, mammary gland duct morphogenesis, mesodermal cell migration, negative regulation of osteoblast differentiation, nervous system development, osteoblast development, positive regulation of DNA-templated transcription, positive regulation of cell differentiation, positive regulation of cell population proliferation, positive regulation of fat cell differentiation, positive regulation of mesenchymal cell proliferation, positive regulation of mitotic nuclear division, positive regulation of osteoblast differentiation, positive regulation of osteoblast proliferation, positive regulation of skeletal muscle acetylcholine-gated channel clustering, positive regulation of transcription by RNA polymerase II, regulation of apoptotic process, regulation of biological quality, regulation of blood pressure, regulation of insulin secretion involved in cellular response to glucose stimulus, regulation of osteoblast differentiation, response to peptide hormone, retina morphogenesis in camera-type eye, retina vasculature development in camera-type eye, retina vasculature morphogenesis in camera-type eye, retinal blood vessel morphogenesis, small molecule metabolic process, somatic stem cell population maintenance, vasculature development; MF: Wnt receptor activity, Wnt-protein binding, coreceptor activity, protein binding; CC: endoplasmic reticulum, membrane, mitochondrion, plasma membrane, receptor complex
Pathways: Alzheimer disease - Mus musculus (mouse), Breast cancer - Mus musculus (mouse), Disassembly of the destruction complex and recruitment of AXIN to the membrane, Gastric cancer - Mus musculus (mouse), Hepatocellular carcinoma - Mus musculus (mouse), Negative regulation of TCF-dependent signaling by WNT ligand antagonists, Parathyroid hormone synthesis, secretion and action - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Regulation of FZD by ubiquitination, Signal Transduction, Signaling by WNT, TCF dependent signaling in response to WNT, Wnt signaling pathway - Mus musculus (mouse), mTOR signaling pathway - Mus musculus (mouse)
UniProt: Q91VN0
Entrez ID: 16973
|
Does Knockout of Dhrs7b in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,275
|
Knockout
|
Dhrs7b
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Dhrs7b (dehydrogenase/reductase 7B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: adipose tissue development, brown fat cell differentiation, ether lipid biosynthetic process, fat cell differentiation, inflammatory response, negative regulation of DNA-templated transcription, neutrophil differentiation, phosphatidylcholine biosynthetic process, regulation of DNA-templated transcription, regulation of cold-induced thermogenesis, regulation of gene expression; MF: DNA-binding transcription factor binding, acylglycerone-phosphate reductase (NADP+) activity, oxidoreductase activity, oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor, protein binding, transcription corepressor activity; CC: cytoplasm, endoplasmic reticulum, endoplasmic reticulum membrane, membrane, nucleus, peroxisomal membrane, peroxisome, transcription regulator complex
Pathways: Metabolism, Metabolism of lipids, Plasmalogen biosynthesis, Wax and plasmalogen biosynthesis
UniProt: Q99J47
Entrez ID: 216820
|
Does Knockout of Fam124a in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,681
|
Knockout
|
Fam124a
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Fam124a (family with sequence similarity 124, member A)
Type: protein-coding
Summary: Orthologous to human FAM124A (family with sequence similarity 124 member A). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology:
Pathways:
UniProt: D3Z5V4
Entrez ID: 629059
|
Does Knockout of Mettl27 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,280
|
Knockout
|
Mettl27
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Mettl27 (methyltransferase like 27)
Type: protein-coding
Summary: Orthologous to human METTL27 (methyltransferase like 27). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology:
Pathways:
UniProt: Q8BGM4, Q8BY07, F6RCZ2, A0A0J9YUG5, D3Z271
Entrez ID: 79565
|
Does Knockout of Smug1 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,275
|
Knockout
|
Smug1
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Smug1 (single-strand selective monofunctional uracil DNA glycosylase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, base-excision repair; MF: DNA N-glycosylase activity, DNA binding, hydrolase activity, identical protein binding, oxidized base lesion DNA N-glycosylase activity, oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity, single-strand selective uracil DNA N-glycosylase activity, single-stranded DNA binding, uracil DNA N-glycosylase activity; CC: cytosol, fibrillar center, nucleolus, nucleoplasm, nucleus
Pathways: Base Excision Repair, Base excision repair - Mus musculus (mouse), Base-Excision Repair, AP Site Formation, Cleavage of the damaged pyrimidine , DNA Repair, Depyrimidination, Displacement of DNA glycosylase by APEX1, Resolution of Abasic Sites (AP sites)
UniProt: Q6P5C5
Entrez ID: 71726
|
Does Knockout of Syn1 in Microglial Cell Line causally result in protein/peptide distribution?
| 0
| 1,585
|
Knockout
|
Syn1
|
protein/peptide distribution
|
Microglial Cell Line
|
Gene: Syn1 (synapsin I)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: neuron development, neurotransmitter secretion, regulation of short-term neuronal synaptic plasticity, regulation of synaptic vesicle cycle, regulation of synaptic vesicle exocytosis, synapse organization, synaptic vesicle clustering, synaptic vesicle cycle; MF: ATP binding, actin binding, calcium-dependent protein binding, identical protein binding, protein binding, protein kinase binding; CC: Golgi apparatus, Schaffer collateral - CA1 synapse, axon, cell body, cell projection, clathrin-sculpted glutamate transport vesicle membrane, cytoplasmic vesicle, cytoskeleton, dendrite, extrinsic component of synaptic vesicle membrane, myelin sheath, postsynaptic density, presynapse, presynaptic active zone, synapse, synaptic vesicle, synaptic vesicle membrane, synaptonemal complex
Pathways: Dopamine Neurotransmitter Release Cycle, Neuronal System, Neurotransmitter release cycle, Serotonin Neurotransmitter Release Cycle, Transmission across Chemical Synapses
UniProt: O88935
Entrez ID: 20964
|
Does Knockout of Cxcl14 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 2,477
|
Knockout
|
Cxcl14
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Cxcl14 (C-X-C motif chemokine ligand 14)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: antimicrobial humoral immune response mediated by antimicrobial peptide, cell chemotaxis, immune response, inner ear development, killing of cells of another organism, negative regulation of myoblast differentiation, positive regulation of natural killer cell chemotaxis, signal transduction; MF: chemokine activity, cytokine activity; CC: Golgi apparatus, extracellular region, extracellular space
Pathways: Chemokine signaling pathway - Mus musculus (mouse), Cytokine-cytokine receptor interaction - Mus musculus (mouse), Viral protein interaction with cytokine and cytokine receptor - Mus musculus (mouse)
UniProt: Q9WUQ5
Entrez ID: 57266
|
Does Knockout of Rassf4 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 2,477
|
Knockout
|
Rassf4
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Rassf4 (Ras association (RalGDS/AF-6) domain family member 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: signal transduction
Pathways: Hippo signaling pathway - multiple species - Mus musculus (mouse)
UniProt: Q8CB96
Entrez ID: 213391
|
Does Knockout of Foxp4 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,278
|
Knockout
|
Foxp4
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Foxp4 (forkhead box P4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: embryonic foregut morphogenesis, heart development, lung epithelium development, lung secretory cell differentiation, negative regulation of lung goblet cell differentiation, negative regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of lung goblet cell differentiation, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, identical protein binding, metal ion binding, protein binding, sequence-specific DNA binding, zinc ion binding; CC: cytosol, nucleoplasm, nucleus
Pathways:
UniProt: Q9DBY0
Entrez ID: 74123
|
Does Knockout of Naprt in Embryonic Fibroblast Cell Line causally result in response to virus?
| 0
| 1,133
|
Knockout
|
Naprt
|
response to virus
|
Embryonic Fibroblast Cell Line
|
Gene: Naprt (nicotinate phosphoribosyltransferase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: NAD+ biosynthetic process, NAD+ biosynthetic process via the salvage pathway, pyridine nucleotide biosynthetic process, response to oxidative stress; MF: ligase activity, metal ion binding, nicotinate phosphoribosyltransferase activity, transferase activity; CC: cytoplasm, cytosol
Pathways: Immune System, Innate Immune System, Metabolism, Metabolism of vitamins and cofactors, Metabolism of water-soluble vitamins and cofactors, Neutrophil degranulation, Nicotinate and nicotinamide metabolism - Mus musculus (mouse), Nicotinate metabolism, pyridine nucleotide cycling
UniProt: Q8CC86
Entrez ID: 223646
|
Does Knockout of Bcl11b in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,679
|
Knockout
|
Bcl11b
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Bcl11b (B cell leukemia/lymphoma 11B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: T cell differentiation, T cell differentiation in thymus, T cell receptor V(D)J recombination, alpha-beta T cell differentiation, axonogenesis, central nervous system neuron differentiation, commitment of neuronal cell to specific neuron type in forebrain, epithelial cell morphogenesis, hematopoietic stem cell migration, keratinocyte development, lymphoid lineage cell migration into thymus, negative regulation of T cell apoptotic process, negative regulation of cell population proliferation, negative regulation of thymocyte apoptotic process, odontogenesis of dentin-containing tooth, olfactory bulb axon guidance, positive T cell selection, positive regulation of transcription by RNA polymerase II, post-embryonic camera-type eye development, post-embryonic development, regulation of gene expression, regulation of keratinocyte proliferation, regulation of lipid metabolic process, regulation of neuron differentiation, regulation of transcription by RNA polymerase II, skin development, striatal medium spiny neuron differentiation, thymus development; MF: DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, protein binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding, zinc ion binding; CC: SWI/SNF complex, neuron projection, nucleoplasm, nucleus
Pathways: ATP-dependent chromatin remodelers, Chromatin organization, Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF), Formation of the embryonic stem cell BAF (esBAF) complex, SWI/SNF chromatin remodelers, Transcriptional misregulation in cancer - Mus musculus (mouse)
UniProt: Q99PV8
Entrez ID: 58208
|
Does Knockout of Lin54 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Lin54
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Lin54 (lin-54 DREAM MuvB core complex component)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: nucleosome organization, regulation of DNA-templated transcription; MF: DNA binding, metal ion binding, minor groove of adenine-thymine-rich DNA binding, transcription regulatory region nucleic acid binding; CC: RNA polymerase II transcription repressor complex, nucleus
Pathways: Cell Cycle, Cell Cycle, Mitotic, Cellular senescence - Mus musculus (mouse), G0 and Early G1, Mitotic G1 phase and G1/S transition
UniProt: Q571G4
Entrez ID: 231506
|
Does Knockout of Washc4 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 1
| 2,307
|
Knockout
|
Washc4
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Washc4 (WASH complex subunit 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cognition, endolysosomal toll-like receptor signaling pathway, endosomal transport, endosome organization, neuromuscular process, protein transport, regulation of Arp2/3 complex-mediated actin nucleation, regulation of protein complex stability; CC: BLOC-1 complex, WASH complex, early endosome, early endosome membrane, endosome, nucleoplasm
Pathways: Endocytosis - Mus musculus (mouse)
UniProt: Q3UMB9
Entrez ID: 319277
|
Does Knockout of Ctbp2 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 2,477
|
Knockout
|
Ctbp2
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Ctbp2 (C-terminal binding protein 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell differentiation, cellular response to leukemia inhibitory factor, maintenance of presynaptic active zone structure, negative regulation of DNA-templated transcription, positive regulation of retinoic acid receptor signaling pathway, positive regulation of transcription by RNA polymerase II, regulation of transcription by RNA polymerase II, synaptic vesicle docking, white fat cell differentiation; MF: DNA-binding transcription factor binding, NAD binding, chromatin binding, identical protein binding, nuclear retinoic acid receptor binding, oxidoreductase activity, oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor, protein binding, protein kinase binding, protein-containing complex binding, structural constituent of presynaptic active zone, transcription coactivator activity, transcription coregulator binding, transcription corepressor activity, transcription corepressor binding; CC: GABA-ergic synapse, cytosol, glutamatergic synapse, nucleus, photoreceptor ribbon synapse, presynaptic active zone cytoplasmic component, presynaptic cytosol, ribbon synapse, synapse, transcription repressor complex
Pathways: Adherens junctions interactions, Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Chronic myeloid leukemia - Mus musculus (mouse), Degradation of beta-catenin by the destruction complex, Negative Regulation of CDH1 Gene Transcription, Notch signaling pathway - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Regulation of CDH1 Expression and Function, Regulation of CDH1 Gene Transcription, Regulation of Expression and Function of Type I Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion, Repression of WNT target genes, Signal Transduction, Signaling by WNT, Wnt signaling pathway - Mus musculus (mouse)
UniProt: P56546
Entrez ID: 13017
|
Does Knockout of Gm13040 in Immortal mouse chromaffin cells causally result in cell viability?
| 0
| 2,469
|
Knockout
|
Gm13040
|
cell viability
|
Immortal mouse chromaffin cells
|
Gene: Gm13040 (predicted gene 13040)
Type: protein-coding
Summary: Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be part of Cul2-RING ubiquitin ligase complex. Predicted to be active in cytoplasm. Orthologous to several human genes including PRAMEF1 (PRAME family member 1); PRAMEF10 (PRAME family member 10); and PRAMEF11 (PRAME family member 11). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: biological_process, negative regulation of DNA-templated transcription, negative regulation of apoptotic process, negative regulation of cell differentiation, positive regulation of cell population proliferation, proteasome-mediated ubiquitin-dependent protein catabolic process; MF: molecular_function, ubiquitin-like ligase-substrate adaptor activity; CC: Cul2-RING ubiquitin ligase complex, cellular_component, cytoplasm
Pathways:
UniProt: Q4FZF9
Entrez ID: 100040854
|
Does Knockout of Mterf2 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,264
|
Knockout
|
Mterf2
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Mterf2 (mitochondrial transcription termination factor 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: DNA binding, nucleic acid binding; CC: mitochondrial matrix, mitochondrial nucleoid, mitochondrion
Pathways:
UniProt: Q8BKY8
Entrez ID: 74238
|
Does Knockout of Rad52 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 579
|
Knockout
|
Rad52
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Rad52 (RAD52 homolog, DNA repair protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA double-strand break processing involved in repair via single-strand annealing, DNA recombinase assembly, DNA recombination, DNA repair, cellular response to oxidative stress, double-strand break repair via homologous recombination, double-strand break repair via single-strand annealing, mitotic recombination, regulation of nucleotide-excision repair; MF: DNA binding, identical protein binding, single-stranded DNA binding; CC: nucleus, protein-DNA complex, protein-containing complex
Pathways: DNA Double-Strand Break Repair, DNA Repair, HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), HDR through MMEJ (alt-NHEJ), HDR through Single Strand Annealing (SSA), Homologous recombination - Mus musculus (mouse), Homology Directed Repair, Metabolism of proteins, Post-translational protein modification, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of DNA damage response and repair proteins
UniProt: P43352
Entrez ID: 19365
|
Does Knockout of Rai1 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 161
|
Knockout
|
Rai1
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Rai1 (retinoic acid induced 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: circadian regulation of gene expression, negative regulation of multicellular organism growth, positive regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II, rhythmic process, skeletal system development; MF: metal ion binding, zinc ion binding; CC: cytoplasm, nucleoplasm, nucleus
Pathways:
UniProt: Q61818
Entrez ID: 19377
|
Does Knockout of Picalm in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 83
|
Knockout
|
Picalm
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Picalm (phosphatidylinositol binding clathrin assembly protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: amyloid-beta clearance by transcytosis, axonogenesis, clathrin coat assembly, clathrin-dependent endocytosis, dendrite morphogenesis, endocytosis, endosomal transport, hemopoiesis, intracellular iron ion homeostasis, learning or memory, membrane bending, multicellular organismal-level iron ion homeostasis, negative regulation of gene expression, negative regulation of protein localization to cell surface, negative regulation of protein localization to plasma membrane, negative regulation of receptor-mediated endocytosis, positive regulation of DNA-templated transcription, positive regulation of Ras protein signal transduction, positive regulation of amyloid precursor protein catabolic process, positive regulation of amyloid-beta formation, positive regulation of axonogenesis, positive regulation of dendrite extension, positive regulation of synaptic vesicle clustering, positive regulation of synaptic vesicle endocytosis, receptor internalization, receptor-mediated endocytosis, regulation of amyloid precursor protein catabolic process, regulation of amyloid-beta formation, regulation of endocytosis, regulation of protein localization, regulation of protein transport, regulation of synaptic vesicle endocytosis, regulation of synaptic vesicle transport, regulation of terminal button organization, regulation of vesicle size, synaptic vesicle endocytosis, synaptic vesicle maturation, vesicle budding from membrane, vesicle cargo loading, vesicle-mediated transport; MF: 1-phosphatidylinositol binding, SH3 domain binding, SNARE binding, clathrin binding, clathrin heavy chain binding, identical protein binding, low-density lipoprotein particle receptor binding, phosphatidylinositol-4,5-bisphosphate binding, phospholipid binding, small GTPase binding, tau protein binding; CC: Golgi apparatus, Schaffer collateral - CA1 synapse, cell surface, clathrin coat of coated pit, clathrin-coated pit, clathrin-coated vesicle, cytoplasmic vesicle, early endosome, endosome, endosome to plasma membrane transport vesicle, extrinsic component of presynaptic endocytic zone membrane, membrane, neurofibrillary tangle, neuronal cell body, nucleus, parallel fiber to Purkinje cell synapse, perinuclear region of cytoplasm, plasma membrane, postsynapse, postsynaptic density, postsynaptic endocytic zone, postsynaptic membrane, presynaptic membrane, synaptic vesicle, vesicle
Pathways: Cargo recognition for clathrin-mediated endocytosis, Clathrin-mediated endocytosis, Golgi Associated Vesicle Biogenesis, Membrane Trafficking, RHO GTPase cycle, RND3 GTPase cycle, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Vesicle-mediated transport, trans-Golgi Network Vesicle Budding
UniProt: Q7M6Y3
Entrez ID: 233489
|
Does Knockout of Dpep2 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 83
|
Knockout
|
Dpep2
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Dpep2 (dipeptidase 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: leukotriene D4 catabolic process, leukotriene metabolic process, lipid metabolic process, proteolysis; MF: dipeptidase activity, exopeptidase activity, hydrolase activity, metal ion binding, metallodipeptidase activity, metallopeptidase activity, peptidase activity; CC: membrane, plasma membrane, side of membrane
Pathways: Aflatoxin activation and detoxification, Arachidonate metabolism, Biological oxidations, Fatty acid metabolism, Metabolism, Metabolism of lipids, Synthesis of Leukotrienes (LT) and Eoxins (EX)
UniProt: Q8C255
Entrez ID: 319446
|
Does Knockout of Ints3 in Melanoma Cell Line causally result in cell proliferation?
| 1
| 1,270
|
Knockout
|
Ints3
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Ints3 (integrator complex subunit 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, RNA polymerase II transcription initiation surveillance, double-strand break repair via homologous recombination, mitotic G2/M transition checkpoint, response to ionizing radiation, snRNA processing; CC: INTAC complex, SOSS complex, cytoplasm, integrator complex, nucleus, site of double-strand break
Pathways: Gene expression (Transcription), RNA Polymerase II Transcription, RNA polymerase II transcribes snRNA genes
UniProt: Q7TPD0
Entrez ID: 229543
|
Does Knockout of Ano3 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,681
|
Knockout
|
Ano3
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Ano3 (anoctamin 3)
Type: protein-coding
Summary: Enables phospholipid scramblase activity. Acts upstream of or within calcium activated galactosylceramide scrambling; calcium activated phosphatidylcholine scrambling; and establishment of localization in cell. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; apical ectodermal ridge; nervous system; sensory organ; and skeleton. Human ortholog(s) of this gene implicated in dystonia 24. Orthologous to human ANO3 (anoctamin 3). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: calcium activated galactosylceramide scrambling, calcium activated phosphatidylcholine scrambling, chloride transmembrane transport, detection of mechanical stimulus, detection of temperature stimulus, establishment of localization in cell, lipid transport; MF: chloride channel activity, phospholipid scramblase activity, protein dimerization activity; CC: membrane, plasma membrane
Pathways: Ion channel transport, Stimuli-sensing channels, Transport of small molecules
UniProt: A2AHL1
Entrez ID: 228432
|
Does Knockout of Rdx in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 165
|
Knockout
|
Rdx
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Rdx (radixin)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: actin filament capping, apical protein localization, barbed-end actin filament capping, cellular response to platelet-derived growth factor stimulus, cellular response to thyroid hormone stimulus, establishment of endothelial barrier, establishment of protein localization, establishment of protein localization to plasma membrane, microvillus assembly, positive regulation of G1/S transition of mitotic cell cycle, positive regulation of early endosome to late endosome transport, positive regulation of gene expression, positive regulation of protein catabolic process, positive regulation of protein localization to early endosome, protein kinase A signaling, protein localization to plasma membrane, regulation of Rap protein signal transduction, regulation of adherens junction organization, regulation of cell shape, regulation of organelle assembly, regulation of postsynaptic neurotransmitter receptor diffusion trapping; MF: ATPase binding, actin binding, cell adhesion molecule binding, cytoskeletal protein binding, protein binding, protein domain specific binding, protein kinase A binding; CC: T-tubule, adherens junction, apical part of cell, apical plasma membrane, cell periphery, cell projection, cell tip, cleavage furrow, cortical actin cytoskeleton, cytoplasm, cytoskeleton, cytosol, filopodium, focal adhesion, lamellipodium, membrane, microvillus, midbody, myelin sheath, plasma membrane, ruffle, stereocilium, stereocilium base
Pathways: Axon guidance, Developmental Biology, L1CAM interactions, MicroRNAs in cancer - Mus musculus (mouse), Nervous system development, Proteoglycans in cancer - Mus musculus (mouse), Recycling pathway of L1, Regulation of actin cytoskeleton - Mus musculus (mouse), Tight junction - Mus musculus (mouse)
UniProt: P26043
Entrez ID: 19684
|
Does Knockout of Fzd4 in Embryonic Fibroblast Cell Line causally result in response to virus?
| 0
| 1,133
|
Knockout
|
Fzd4
|
response to virus
|
Embryonic Fibroblast Cell Line
|
Gene: Fzd4 (frizzled class receptor 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, Norrin signaling pathway, Wnt signaling pathway, Wnt signaling pathway, calcium modulating pathway, angiogenesis, blood vessel development, canonical Wnt signaling pathway, cell population proliferation, cell surface receptor signaling pathway, cellular response to leukemia inhibitory factor, cerebellum vasculature morphogenesis, cytokine-mediated signaling pathway, endothelial cell differentiation, establishment of blood-brain barrier, extracellular matrix-cell signaling, locomotion involved in locomotory behavior, luteinization, negative regulation of cell-substrate adhesion, non-canonical Wnt signaling pathway, positive regulation of DNA-templated transcription, positive regulation of cell migration, positive regulation of dendrite morphogenesis, positive regulation of neuron projection arborization, positive regulation of transcription by RNA polymerase II, progesterone secretion, regulation of vascular endothelial growth factor receptor signaling pathway, response to hypoxia, retina vasculature development in camera-type eye, retina vasculature morphogenesis in camera-type eye, retinal blood vessel morphogenesis, sensory perception of sound, signal transduction, substrate adhesion-dependent cell spreading, vasculogenesis; MF: G protein-coupled receptor activity, PDZ domain binding, Wnt receptor activity, Wnt-protein binding, amyloid-beta binding, cytokine binding, cytokine receptor activity, protein binding, protein heterodimerization activity, protein homodimerization activity, protein-containing complex binding, signaling receptor activity, transmembrane signaling receptor activity, ubiquitin protein ligase binding; CC: cell surface, cell-cell junction, cilium, dendrite, glutamatergic synapse, membrane, nucleoplasm, plasma membrane, synapse
Pathways: Alzheimer disease - Mus musculus (mouse), Asymmetric localization of PCP proteins, Basal cell carcinoma - Mus musculus (mouse), Beta-catenin independent WNT signaling, Breast cancer - Mus musculus (mouse), Ca2+ pathway, Cargo recognition for clathrin-mediated endocytosis, Clathrin-mediated endocytosis, Cushing syndrome - Mus musculus (mouse), Gastric cancer - Mus musculus (mouse), Hepatocellular carcinoma - Mus musculus (mouse), Hippo signaling pathway - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), Melanogenesis - Mus musculus (mouse), Membrane Trafficking, PCP/CE pathway, Pathways in cancer - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Proteoglycans in cancer - Mus musculus (mouse), Regulation of FZD by ubiquitination, Signal Transduction, Signaling by WNT, Signaling pathways regulating pluripotency of stem cells - Mus musculus (mouse), TCF dependent signaling in response to WNT, Vesicle-mediated transport, WNT5A-dependent internalization of FZD4, Wnt signaling pathway - Mus musculus (mouse), mTOR signaling pathway - Mus musculus (mouse)
UniProt: Q61088
Entrez ID: 14366
|
Does Knockout of Chst8 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 2,477
|
Knockout
|
Chst8
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Chst8 (carbohydrate sulfotransferase 8)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: carbohydrate biosynthetic process, hormone biosynthetic process, peptide hormone processing, proteoglycan biosynthetic process, sulfur compound metabolic process; MF: dermatan 4-sulfotransferase activity, sulfotransferase activity, transferase activity; CC: Golgi apparatus, Golgi membrane, membrane
Pathways: Asparagine N-linked glycosylation, Metabolism of proteins, N-glycan antennae elongation in the medial/trans-Golgi, Post-translational protein modification, Reactions specific to the complex N-glycan synthesis pathway, Transport to the Golgi and subsequent modification, Various types of N-glycan biosynthesis - Mus musculus (mouse)
UniProt: Q8BQ86
Entrez ID: 68947
|
Does Knockout of Slc6a20b in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 161
|
Knockout
|
Slc6a20b
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Slc6a20b (solute carrier family 6 (neurotransmitter transporter), member 20B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: L-proline import across plasma membrane, amino acid import across plasma membrane, amino acid transport, amino-acid betaine transport, glycine import across plasma membrane, glycine transport, proline import across plasma membrane, proline transport, sodium ion transmembrane transport; MF: L-proline transmembrane transporter activity, amino acid transmembrane transporter activity, amino-acid betaine transmembrane transporter activity, neutral L-amino acid transmembrane transporter activity, proline:sodium symporter activity, protein binding, solute:sodium symporter activity, symporter activity; CC: apical plasma membrane, brush border membrane, membrane, plasma membrane
Pathways:
UniProt: O88575
Entrez ID: 22599
|
Does Knockout of Ntn3 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 165
|
Knockout
|
Ntn3
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Ntn3 (netrin 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: animal organ morphogenesis, axonogenesis, dendrite development, motor neuron axon guidance, myoblast fusion, regulation of DNA-templated transcription, tissue development; MF: signaling receptor binding; CC: Golgi apparatus, basement membrane, cytoplasm, extracellular region
Pathways: Axon guidance - Mus musculus (mouse)
UniProt: Q9R1A3
Entrez ID: 18209
|
Does Knockout of Bard1 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 1,130
|
Knockout
|
Bard1
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Bard1 (BRCA1 associated RING domain 1)
Type: protein-coding
Summary: Predicted to enable RNA binding activity; protein heterodimerization activity; and protein homodimerization activity. Predicted to contribute to ubiquitin-protein transferase activity. Predicted to be involved in several processes, including negative regulation of protein export from nucleus; protein K6-linked ubiquitination; and regulation of apoptotic process. Located in nucleus. Is expressed in central nervous system; genitourinary system; limb; and spleen. Used to study breast cancer. Human ortholog(s) of this gene implicated in breast cancer and ovarian cancer. Orthologous to human BARD1 (BRCA1 associated RING domain 1). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: DNA damage response, DNA repair, DNA strand resection involved in replication fork processing, cellular response to ionizing radiation, homologous recombination, mitotic G2/M transition checkpoint, negative regulation of apoptotic process, negative regulation of protein export from nucleus, positive regulation of apoptotic process, positive regulation of cell cycle, protein K6-linked ubiquitination, protein ubiquitination, regulation of DNA damage checkpoint, regulation of DNA repair, regulation of phosphorylation; MF: RNA binding, metal ion binding, protein heterodimerization activity, protein homodimerization activity, transferase activity, ubiquitin protein ligase activity, ubiquitin-protein transferase activity, zinc ion binding; CC: BRCA1-A complex, BRCA1-B complex, BRCA1-BARD1 complex, BRCA1-C complex, cytoplasm, cytoplasmic ribonucleoprotein granule, nuclear speck, nuclear ubiquitin ligase complex, nucleoplasm, nucleus
Pathways: Cell Cycle, Cell Cycle Checkpoints, DNA Double Strand Break Response, DNA Double-Strand Break Repair, DNA Repair, Deubiquitination, G2/M Checkpoints, G2/M DNA damage checkpoint, Gene expression (Transcription), Generic Transcription Pathway, HDR through Homologous Recombination (HRR), HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), HDR through Single Strand Annealing (SSA), Homologous DNA Pairing and Strand Exchange, Homologous recombination - Mus musculus (mouse), Homology Directed Repair, Metabolism of proteins, Metalloprotease DUBs, Nonhomologous End-Joining (NHEJ), Post-translational protein modification, Presynaptic phase of homologous DNA pairing and strand exchange, Processing of DNA double-strand break ends, RNA Polymerase II Transcription, Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks, Regulation of TP53 Activity, Regulation of TP53 Activity through Phosphorylation, Resolution of D-Loop Structures, Resolution of D-loop Structures through Holliday Junction Intermediates, Transcriptional Regulation by TP53, UCH proteinases
UniProt: O70445
Entrez ID: 12021
|
Does Knockout of Il23a in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,267
|
Knockout
|
Il23a
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Il23a (interleukin 23, alpha subunit p19)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: T cell proliferation, cell surface receptor signaling pathway via JAK-STAT, cell surface receptor signaling pathway via STAT, defense response to Gram-negative bacterium, defense response to virus, immune response, immune system process, inflammatory response, innate immune response, negative regulation of interleukin-10 production, positive regulation of NK T cell activation, positive regulation of NK T cell proliferation, positive regulation of T cell mediated cytotoxicity, positive regulation of T cell proliferation, positive regulation of T-helper 1 type immune response, positive regulation of T-helper 17 cell lineage commitment, positive regulation of T-helper 17 type immune response, positive regulation of activated T cell proliferation, positive regulation of alpha-beta T cell activation, positive regulation of defense response to virus by host, positive regulation of granulocyte macrophage colony-stimulating factor production, positive regulation of interleukin-10 production, positive regulation of interleukin-12 production, positive regulation of interleukin-17 production, positive regulation of leukocyte differentiation, positive regulation of macromolecule biosynthetic process, positive regulation of memory T cell differentiation, positive regulation of natural killer cell proliferation, positive regulation of neutrophil chemotaxis, positive regulation of osteoclast differentiation, positive regulation of transcription by RNA polymerase II, positive regulation of tumor necrosis factor production, positive regulation of type II interferon production, regulation of gene expression, regulation of primary metabolic process, tissue remodeling; MF: cytokine activity, interleukin-23 receptor binding, protein binding; CC: extracellular region, extracellular space, interleukin-23 complex
Pathways: C-type lectin receptor signaling pathway - Mus musculus (mouse), Cytokine Signaling in Immune system, Cytokine-cytokine receptor interaction - Mus musculus (mouse), Immune System, Inflammatory bowel disease - Mus musculus (mouse), Interleukin-12 family signaling, Interleukin-23 signaling, JAK-STAT signaling pathway - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Pertussis - Mus musculus (mouse), Rheumatoid arthritis - Mus musculus (mouse), Signaling by Interleukins, Th17 cell differentiation - Mus musculus (mouse), Tuberculosis - Mus musculus (mouse)
UniProt: Q9EQ14
Entrez ID: 83430
|
Does Knockout of Fitm2 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 1
| 1,271
|
Knockout
|
Fitm2
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Fitm2 (fat storage-inducing transmembrane protein 2)
Type: protein-coding
Summary: Enables diacylglycerol binding activity and triglyceride binding activity. Involved in several processes, including fat cell differentiation; intracellular triglyceride homeostasis; and lipid droplet formation. Acts upstream of or within triglyceride storage. Located in endoplasmic reticulum membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and integumental system. Human ortholog(s) of this gene implicated in Siddiqi syndrome. Orthologous to human FITM2 (fat storage inducing transmembrane protein 2). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: cytoskeleton organization, fat cell differentiation, fatty-acyl-CoA catabolic process, intracellular triglyceride homeostasis, lipid droplet formation, lipid droplet organization, lipid homeostasis, lipid metabolic process, lipid storage, phospholipid biosynthetic process, regulation of cell morphogenesis, triglyceride metabolic process, triglyceride storage; MF: coenzyme A diphosphatase activity, diacylglycerol binding, hydrolase activity, triglyceride binding; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane, mitochondrion
Pathways: Lipid particle organization, Metabolism, Metabolism of lipids
UniProt: P59266
Entrez ID: 228859
|
Does Knockout of Slc35b4 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 1,275
|
Knockout
|
Slc35b4
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Slc35b4 (solute carrier family 35, member B4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: UDP-N-acetylglucosamine transmembrane transport, UDP-xylose transmembrane transport, regulation of gluconeogenesis, transmembrane transport; MF: UDP-N-acetylglucosamine transmembrane transporter activity, UDP-xylose transmembrane transporter activity; CC: Golgi apparatus, Golgi membrane, endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways: SLC-mediated transmembrane transport, Transport of nucleotide sugars, Transport of small molecules, Transport of vitamins, nucleosides, and related molecules
UniProt: Q8CIA5
Entrez ID: 58246
|
Does Knockout of Best1 in Immortal mouse chromaffin cells causally result in cell viability?
| 1
| 2,469
|
Knockout
|
Best1
|
cell viability
|
Immortal mouse chromaffin cells
|
Gene: Best1 (bestrophin 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: bicarbonate transport, chloride transmembrane transport, chloride transport, detection of light stimulus involved in visual perception, gamma-aminobutyric acid secretion, neurotransmission, glutamate secretion, monoatomic ion transmembrane transport, monoatomic ion transport, protein complex oligomerization, regulation of calcium ion transport, regulation of synaptic plasticity, transepithelial chloride transport; MF: bicarbonate channel activity, channel activity, chloride channel activity, identical protein binding, intracellularly calcium-gated chloride channel activity, ligand-gated channel activity, metal ion binding; CC: basal plasma membrane, basolateral plasma membrane, chloride channel complex, membrane, membrane microdomain, plasma membrane, presynapse
Pathways: Ion channel transport, Stimuli-sensing channels, Transport of small molecules
UniProt: O88870
Entrez ID: 24115
|
Does Knockout of Ncbp2 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Ncbp2
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Ncbp2 (nuclear cap binding protein subunit 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, alternative mRNA splicing, via spliceosome, cap-dependent translational initiation, histone mRNA metabolic process, mRNA 3'-end processing, mRNA cis splicing, via spliceosome, mRNA export from nucleus, mRNA metabolic process, mRNA processing, mRNA splicing, via spliceosome, mRNA transcription by RNA polymerase II, mRNA transport, miRNA-mediated post-transcriptional gene silencing, nuclear-transcribed mRNA catabolic process, nonsense-mediated decay, positive regulation of RNA export from nucleus, positive regulation of mRNA 3'-end processing, positive regulation of transcription elongation by RNA polymerase II, primary miRNA processing, regulation of translation, regulation of translational initiation, regulatory ncRNA-mediated gene silencing, snRNA export from nucleus; MF: DNA binding, RNA 7-methylguanosine cap binding, RNA binding, RNA cap binding, mRNA binding, nucleic acid binding, snRNA binding; CC: RNA cap binding complex, ciliary basal body, cytoplasm, cytosol, nuclear cap binding complex, nucleoplasm, nucleus
Pathways: FGFR2 alternative splicing, Formation of RNA Pol II elongation complex , Formation of the Early Elongation Complex, Gene expression (Transcription), Metabolism of RNA, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), Nuclear RNA decay, Nucleocytoplasmic transport - Mus musculus (mouse), Processing of Capped Intron-Containing Pre-mRNA, Processing of Capped Intronless Pre-mRNA, Processing of Intronless Pre-mRNAs, RNA Polymerase II Pre-transcription Events, RNA Polymerase II Transcription, RNA Polymerase II Transcription Elongation, RNA Polymerase II Transcription Termination, RNA polymerase II transcribes snRNA genes, SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs, SLBP independent Processing of Histone Pre-mRNAs, Signal Transduction, Signaling by FGFR, Signaling by FGFR2, Signaling by Receptor Tyrosine Kinases, Spliceosome - Mus musculus (mouse), Transport of Mature Transcript to Cytoplasm, Transport of Mature mRNA Derived from an Intronless Transcript, Transport of Mature mRNA derived from an Intron-Containing Transcript, Transport of Mature mRNAs Derived from Intronless Transcripts, Transport of the SLBP Dependant Mature mRNA, Transport of the SLBP independent Mature mRNA, mRNA 3'-end processing, mRNA Capping, mRNA Splicing, mRNA Splicing - Major Pathway, mRNA Splicing - Minor Pathway, mRNA surveillance pathway - Mus musculus (mouse)
UniProt: Q9CQ49
Entrez ID: 68092
|
Does Knockout of Srrd in Mouse kidney carcinoma cell causally result in cell proliferation?
| 1
| 1,271
|
Knockout
|
Srrd
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Srrd (SRR1 domain containing)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: heme biosynthetic process, regulation of circadian rhythm, regulation of heme biosynthetic process, rhythmic process; CC: cytoplasm, nucleus
Pathways:
UniProt: Q8K2M3
Entrez ID: 70118
|
Does Knockout of Ube2v2 in Lymphoma Cell Line causally result in response to chemicals?
| 0
| 1,535
|
Knockout
|
Ube2v2
|
response to chemicals
|
Lymphoma Cell Line
|
Gene: Ube2v2 (ubiquitin-conjugating enzyme E2 variant 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA double-strand break processing, error-free postreplication DNA repair, negative regulation of neuron apoptotic process, positive regulation of DNA repair, positive regulation of double-strand break repair, positive regulation of neuron projection development, positive regulation of proteasomal ubiquitin-dependent protein catabolic process, positive regulation of protein K63-linked ubiquitination, positive regulation of synapse assembly, postreplication repair, protein K63-linked ubiquitination; CC: UBC13-MMS2 complex, nucleoplasm, nucleus, ubiquitin conjugating enzyme complex
Pathways: Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Cell Cycle, Cell Cycle Checkpoints, Class I MHC mediated antigen processing & presentation, DNA Double Strand Break Response, DNA Double-Strand Break Repair, DNA Repair, E3 ubiquitin ligases ubiquitinate target proteins, Formation of Incision Complex in GG-NER, G2/M Checkpoints, G2/M DNA damage checkpoint, Global Genome Nucleotide Excision Repair (GG-NER), HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), Homology Directed Repair, Immune System, Metabolism of proteins, Nonhomologous End-Joining (NHEJ), Nucleotide Excision Repair, Post-translational protein modification, Processing of DNA double-strand break ends, Protein ubiquitination, Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
UniProt: Q9D2M8
Entrez ID: 70620
|
Does Knockout of Wdr73 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 81
|
Knockout
|
Wdr73
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Wdr73 (WD repeat domain 73)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cytoplasmic microtubule organization, nucleus organization; MF: molecular_function, protein-macromolecule adaptor activity; CC: cleavage furrow, cytoplasm, cytoskeleton, cytosol, spindle, spindle pole
Pathways:
UniProt: Q9CWR1
Entrez ID: 71968
|
Does Knockout of Lrrd1 in Embryonic Fibroblast Cell Line causally result in response to virus?
| 0
| 1,133
|
Knockout
|
Lrrd1
|
response to virus
|
Embryonic Fibroblast Cell Line
|
Gene: Lrrd1 (leucine rich repeats and death domain containing 1)
Type: protein-coding
Summary: Predicted to be involved in inflammatory response; innate immune response; and intracellular signal transduction. Orthologous to human LRRD1 (leucine rich repeats and death domain containing 1). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: inflammatory response, innate immune response, intracellular signal transduction
Pathways:
UniProt: Q8C0R9
Entrez ID: 242838
|
Does Knockout of Nelfb in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,262
|
Knockout
|
Nelfb
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Nelfb (negative elongation factor complex member B)
Type: protein-coding
Summary: This gene encodes subunit B of a metazoan-specific, four-subunit protein complex that regulates promoter-proximal pausing of RNA polymerase II. RNA polymerase II pausing is thought to be important for coordination of gene transcription during embryonic development and stress responses. Consistently, disruption of this gene in mouse causes inner cell mass deficiency and embryonic lethality. In addition, this gene is required for maintenance of mouse embryonic stem cells by preventing expression of developmental genes. In adult mice, conditional deletion of this gene results in cardiomyopathy and impaired response to cardiac stress. Multiple protein isoforms are encoded through the use of a non-AUG (CUG) initiation codon and an alternative downstream AUG initiation codon. In addition, alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015].
Gene Ontology: BP: cell population proliferation, negative regulation of DNA-templated transcription, negative regulation of stem cell differentiation, negative regulation of transcription elongation by RNA polymerase II, stem cell differentiation; MF: RNA binding, protein binding; CC: NELF complex, cytoplasm, cytosol, mitochondrial outer membrane, nucleoplasm, nucleus
Pathways: Formation of RNA Pol II elongation complex , Formation of the Early Elongation Complex, Gene expression (Transcription), Generic Transcription Pathway, RNA Polymerase II Pre-transcription Events, RNA Polymerase II Transcription, RNA Polymerase II Transcription Elongation, TP53 Regulates Transcription of DNA Repair Genes, Transcriptional Regulation by TP53
UniProt: Q8C4Y3
Entrez ID: 58202
|
Does Knockout of Acin1 in Microglial Cell Line causally result in response to virus?
| 0
| 2,429
|
Knockout
|
Acin1
|
response to virus
|
Microglial Cell Line
|
Gene: Acin1 (apoptotic chromatin condensation inducer 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, apoptotic chromosome condensation, apoptotic process, erythrocyte differentiation, mRNA processing, negative regulation of mRNA splicing, via spliceosome, positive regulation of apoptotic process, positive regulation of monocyte differentiation; CC: ASAP complex, cytosol, exon-exon junction complex, nuclear lumen, nuclear speck, nucleolus, nucleoplasm, nucleus, plasma membrane
Pathways: Nucleocytoplasmic transport - Mus musculus (mouse), Spliceosome - Mus musculus (mouse), mRNA surveillance pathway - Mus musculus (mouse)
UniProt: Q9JIX8
Entrez ID: 56215
|
Does Knockout of Tpm1 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,265
|
Knockout
|
Tpm1
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Tpm1 (tropomyosin 1, alpha)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: actin filament capping, actin filament organization, cardiac muscle contraction, in utero embryonic development, muscle filament sliding, negative regulation of cell migration, negative regulation of vascular associated smooth muscle cell migration, negative regulation of vascular associated smooth muscle cell proliferation, positive regulation of cell adhesion, positive regulation of heart rate by epinephrine, positive regulation of stress fiber assembly, regulation of cell shape, ruffle organization, sarcomere organization, ventricular cardiac muscle tissue morphogenesis, wound healing; MF: actin binding, actin filament binding, cytoskeletal protein binding, disordered domain specific binding, identical protein binding, protein binding, protein heterodimerization activity, protein homodimerization activity, structural constituent of cytoskeleton; CC: actin cytoskeleton, actin filament, bleb, cytoplasm, cytoskeleton, cytosol, muscle thin filament tropomyosin, myofibril, protein-containing complex, ruffle membrane, stress fiber
Pathways: Adrenergic signaling in cardiomyocytes - Mus musculus (mouse), Cardiac muscle contraction - Mus musculus (mouse), Dilated cardiomyopathy - Mus musculus (mouse), Hypertrophic cardiomyopathy - Mus musculus (mouse), MicroRNAs in cancer - Mus musculus (mouse), Muscle contraction, Smooth Muscle Contraction, Striated Muscle Contraction
UniProt: P58771
Entrez ID: 22003
|
Does Knockout of Ap3s1 in Acute Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 684
|
Knockout
|
Ap3s1
|
cell proliferation
|
Acute Myeloid Leukemia Cell Line
|
Gene: Ap3s1 (adaptor-related protein complex 3, sigma 1 subunit)
Type: protein-coding
Summary: This gene encodes the sigma subunit of the heterotetrameric adaptor protein complex AP-3 which is involved in the formation of specialized lysosome-related compartments such as melanosomes. Alternate splicing of this gene results in multiple transcript variants encoding different isoforms. Pseudogenes of this gene are found on chromosomes 1, 8, 16, 17 and X. [provided by RefSeq, Dec 2014].
Gene Ontology: BP: Golgi to vacuole transport, anterograde axonal transport, anterograde synaptic vesicle transport, clathrin-coated vesicle cargo loading, AP-3-mediated, intracellular protein transport, melanosome assembly, platelet dense granule organization, protein transport, synaptic vesicle coating, synaptic vesicle recycling, vesicle-mediated transport; CC: AP-3 adaptor complex, Golgi apparatus, axon cytoplasm, cytoplasmic vesicle, cytoplasmic vesicle membrane, early endosome, intracellular membrane-bounded organelle, membrane, membrane coat, presynapse, synaptic vesicle, trans-Golgi network
Pathways: Golgi Associated Vesicle Biogenesis, Lysosome - Mus musculus (mouse), Membrane Trafficking, Vesicle-mediated transport, trans-Golgi Network Vesicle Budding
UniProt: Q9DCR2
Entrez ID: 11777
|
Does Knockout of Kat7 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 81
|
Knockout
|
Kat7
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Kat7 (K(lysine) acetyltransferase 7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, DNA replication, DNA replication-dependent chromatin disassembly, T cell differentiation, chromatin organization, internal peptidyl-lysine acetylation, natural killer cell differentiation, positive regulation of DNA replication, positive regulation of DNA-templated transcription, elongation, positive regulation of erythrocyte differentiation, positive regulation of hematopoietic stem cell proliferation, positive regulation of nucleobase-containing compound metabolic process, positive regulation of protein localization to nucleus, positive regulation of transcription by RNA polymerase II, regulation of DNA biosynthetic process, regulation of DNA replication, regulation of DNA-templated DNA replication initiation, regulation of DNA-templated transcription, regulation of cell cycle, regulation of cell growth, regulation of nucleotide-excision repair, regulation of transcription by RNA polymerase II, response to actinomycin D, response to anisomycin, response to dithiothreitol, response to hydroxyurea, response to sorbitol, stress-activated protein kinase signaling cascade, transcription initiation-coupled chromatin remodeling; MF: DNA replication origin binding, acyltransferase activity, chromatin binding, histone H3 acetyltransferase activity, histone H3K14 acetyltransferase activity, histone H3K23 acetyltransferase activity, histone H3K4 acetyltransferase activity, histone H4 acetyltransferase activity, histone H4K12 acetyltransferase activity, histone H4K16 acetyltransferase activity, histone H4K5 acetyltransferase activity, histone H4K8 acetyltransferase activity, histone acetyltransferase activity, metal ion binding, protein-lysine-acetyltransferase activity, transcription coregulator activity, transferase activity, zinc ion binding; CC: chromatin, chromosome, chromosome, centromeric region, cytoplasm, cytosol, histone H3-K14 acetyltransferase complex, histone acetyltransferase complex, nucleolus, nucleoplasm, nucleus, site of DNA damage
Pathways: Chromatin modifying enzymes, Chromatin organization, HATs acetylate histones
UniProt: Q5SVQ0
Entrez ID: 217127
|
Does Knockout of Tapt1 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,679
|
Knockout
|
Tapt1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Tapt1 (transmembrane anterior posterior transformation 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cartilage development, cell differentiation, cell projection organization, embryonic skeletal system development, neural crest cell development, ossification, positive regulation of bone development, positive regulation of cartilage development, positive regulation of cilium assembly; CC: cell projection, centrosome, ciliary basal body, cilium, cytoplasm, cytoskeleton, cytosol, endoplasmic reticulum membrane, membrane, nucleoplasm
Pathways:
UniProt: Q4VBD2
Entrez ID: 231225
|
Does Knockout of Rdh8 in Immortal mouse chromaffin cells causally result in cell viability?
| 1
| 2,469
|
Knockout
|
Rdh8
|
cell viability
|
Immortal mouse chromaffin cells
|
Gene: Rdh8 (retinol dehydrogenase 8)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: estrogen biosynthetic process, lipid metabolic process, retinol metabolic process, steroid biosynthetic process, testosterone biosynthetic process, visual perception; MF: all-trans-retinol dehydrogenase (NAD+) activity, all-trans-retinol dehydrogenase (NADP+) activity, estradiol 17-beta-dehydrogenase [NAD(P)+] activity, oxidoreductase activity; CC: cytoplasm, cytosol, membrane
Pathways: Retinol metabolism - Mus musculus (mouse)
UniProt: D3Z6W3
Entrez ID: 235033
|
Does Knockout of Fshr in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,681
|
Knockout
|
Fshr
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Fshr (follicle stimulating hormone receptor)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, Sertoli cell development, Sertoli cell proliferation, adenylate cyclase-activating G protein-coupled receptor signaling pathway, adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway, adenylate cyclase-modulating G protein-coupled receptor signaling pathway, basement membrane organization, cellular response to follicle-stimulating hormone stimulus, follicle-stimulating hormone signaling pathway, hormone-mediated signaling pathway, intracellular water homeostasis, locomotory behavior, male gonad development, negative regulation of bone resorption, neuron projection development, ovarian follicle development, ovulation cycle process, phospholipase C-activating G protein-coupled receptor signaling pathway, positive regulation of ERK1 and ERK2 cascade, positive regulation of intracellular estrogen receptor signaling pathway, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, primary ovarian follicle growth, regulation of MAPK cascade, regulation of acetylcholine metabolic process, regulation of chromosome organization, regulation of hormone metabolic process, regulation of intracellular estrogen receptor signaling pathway, regulation of osteoclast differentiation, regulation of platelet-derived growth factor receptor signaling pathway, regulation of protein kinase A signaling, regulation of systemic arterial blood pressure, signal transduction, sperm DNA condensation, spermatid development, spermatogenesis, transcytosis, uterus development; MF: G protein-coupled peptide receptor activity, G protein-coupled receptor activity, follicle-stimulating hormone receptor activity, peptide hormone binding, protein-hormone receptor activity, signaling receptor activity; CC: cell surface, endosome, membrane, plasma membrane, receptor complex
Pathways: Class A/1 (Rhodopsin-like receptors), G alpha (s) signalling events, GPCR downstream signalling, GPCR ligand binding, Hormone ligand-binding receptors, Neuroactive ligand-receptor interaction - Mus musculus (mouse), Ovarian steroidogenesis - Mus musculus (mouse), Signal Transduction, Signaling by GPCR, cAMP signaling pathway - Mus musculus (mouse)
UniProt: P35378
Entrez ID: 14309
|
Does Knockout of Vmn1r230 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 2,492
|
Knockout
|
Vmn1r230
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Vmn1r230 (vomeronasal 1 receptor 230)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, response to pheromone, sensory perception of chemical stimulus, signal transduction; MF: G protein-coupled receptor activity, pheromone binding, pheromone receptor activity; CC: membrane, plasma membrane
Pathways:
UniProt: Q8R2A2
Entrez ID: 171231
|
Does Knockout of Psmd4 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,681
|
Knockout
|
Psmd4
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Psmd4 (proteasome (prosome, macropain) 26S subunit, non-ATPase, 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: identical protein binding, molecular adaptor activity, polyubiquitin modification-dependent protein binding; CC: cytosol, nucleoplasm, nucleus, proteasome accessory complex, proteasome complex, proteasome regulatory particle, base subcomplex
Pathways: Alzheimer disease - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Epstein-Barr virus infection - Mus musculus (mouse), Huntington disease - Mus musculus (mouse), Metabolism of proteins, Parkinson disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Post-translational protein modification, Prion disease - Mus musculus (mouse), Proteasome - Mus musculus (mouse), Proteasome assembly, Spinocerebellar ataxia - Mus musculus (mouse), Targeted protein degradation
UniProt: O35226
Entrez ID: 19185
|
Does Knockout of Ahi1 in Pancreatic Cancer Cell Line causally result in response to chemicals?
| 0
| 2,359
|
Knockout
|
Ahi1
|
response to chemicals
|
Pancreatic Cancer Cell Line
|
Gene: Ahi1 (Abelson helper integration site 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell differentiation, cell projection organization, cell surface receptor protein tyrosine kinase signaling pathway, cilium assembly, eye photoreceptor cell development, intracellular protein localization, morphogenesis of a polarized epithelium, motile cilium assembly, negative regulation of D-glucose import, negative regulation of apoptotic process, non-motile cilium assembly, photoreceptor cell outer segment organization, positive regulation of gene expression, positive regulation of growth, positive regulation of neuron projection development, positive regulation of polarized epithelial cell differentiation, positive regulation of receptor internalization, positive regulation of transcription by RNA polymerase II, regulation of behavior, regulation of protein secretion, retina development in camera-type eye, retinal cone cell development, retinal rod cell development, vesicle targeting, vesicle-mediated transport; MF: identical protein binding, protein binding; CC: MKS complex, adherens junction, anchoring junction, cell projection, cell-cell junction, centriole, centrosome, ciliary basal body, cilium, cytoplasm, cytoskeleton, non-motile cilium, photoreceptor distal connecting cilium, photoreceptor outer segment
Pathways:
UniProt: E9QP54, E9Q552, A0A1L1SQE2
Entrez ID: 52906
|
Does Knockout of Coil in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 161
|
Knockout
|
Coil
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Coil (coilin)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: U1 snRNA binding, U2 snRNA binding, disulfide oxidoreductase activity, identical protein binding, protein binding; CC: Cajal body, female germ cell nucleus, fibrillar center, nuclear body, nucleolus, nucleoplasm, nucleus
Pathways:
UniProt: Q5SU73
Entrez ID: 12812
|
Does Knockout of Kcnc2 in Embryonic Fibroblast Cell Line causally result in autophagy?
| 1
| 1,043
|
Knockout
|
Kcnc2
|
autophagy
|
Embryonic Fibroblast Cell Line
|
Gene: Kcnc2 (potassium voltage gated channel, Shaw-related subfamily, member 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: action potential, cellular response to ammonium ion, cellular response to nitric oxide, cellular response to toxic substance, globus pallidus development, membrane hyperpolarization, monoatomic ion transmembrane transport, monoatomic ion transport, nitric oxide-cGMP-mediated signaling, optic nerve development, positive regulation of potassium ion transmembrane transport, potassium ion transmembrane transport, potassium ion transport, protein heterooligomerization, protein homooligomerization, regulation of action potential firing rate, regulation of presynaptic membrane potential, response to amine, response to ethanol, response to kainic acid, response to light intensity, response to magnesium ion, response to nerve growth factor, response to toxic substance, transmembrane transport; MF: delayed rectifier potassium channel activity, metal ion binding, monoatomic ion channel activity, potassium channel activity, protein binding, transmembrane transporter binding, voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential, voltage-gated potassium channel activity; CC: GABA-ergic synapse, apical plasma membrane, axolemma, axon, axon terminus, basolateral plasma membrane, cell body, cell projection, dendrite, dendrite membrane, membrane, monoatomic ion channel complex, neuron projection, neuronal cell body, neuronal cell body membrane, perikaryon, plasma membrane, postsynaptic membrane, presynaptic membrane, synapse, terminal bouton, vesicle, voltage-gated potassium channel complex
Pathways: Glucagon-like Peptide-1 (GLP1) regulates insulin secretion, Integration of energy metabolism, Metabolism, Neuronal System, Potassium Channels, Regulation of insulin secretion, Voltage gated Potassium channels
UniProt: Q14B80
Entrez ID: 268345
|
Does Knockout of Tomm20 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 1
| 2,307
|
Knockout
|
Tomm20
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Tomm20 (translocase of outer mitochondrial membrane 20)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: intracellular protein transport, protein import into mitochondrial matrix, protein targeting, protein targeting to mitochondrion, protein transport, response to 3,3',5-triiodo-L-thyronine, response to muscle activity, tRNA import into mitochondrion; MF: mitochondrion targeting sequence binding, protein binding, protein transmembrane transporter activity, protein-transporting ATPase activity, unfolded protein binding; CC: cell periphery, membrane, migrasome, mitochondria-associated endoplasmic reticulum membrane contact site, mitochondrial envelope, mitochondrial outer membrane, mitochondrial outer membrane translocase complex, mitochondrion, sperm midpiece
Pathways: Autophagy, Deubiquitination, Macroautophagy, Metabolism of proteins, Mitophagy, PINK1-PRKN Mediated Mitophagy, Post-translational protein modification, Selective autophagy, Ub-specific processing proteases
UniProt: Q9DCC8
Entrez ID: 67952
|
Does Knockout of Cela2a in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 1,130
|
Knockout
|
Cela2a
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Cela2a (chymotrypsin-like elastase family, member 2A)
Type: protein-coding
Summary: This gene encodes a serine protease enzyme that hydrolyzes elastin. This gene is highly expressed in the pancreatic acinar cells where the encoded preproprotein undergoes processing including signal peptide cleavage to generate an inactive zymogen. The removal of N-terminal activation peptide from the zymogen by trypsin generates active elastase enzyme. This gene is also expressed in the mouse epidermis where it participates in pro-filaggrin processing. [provided by RefSeq, Jul 2016].
Gene Ontology: BP: insulin catabolic process, proteolysis, regulation of insulin secretion, regulation of platelet aggregation, response to insulin; MF: endopeptidase activity, hydrolase activity, peptidase activity, serine hydrolase activity, serine-type endopeptidase activity, serine-type peptidase activity; CC: extracellular matrix, extracellular region, extracellular space, keratohyalin granule
Pathways: Developmental Biology, Formation of the cornified envelope, Keratinization, Pancreatic secretion - Mus musculus (mouse), Protein digestion and absorption - Mus musculus (mouse)
UniProt: P05208
Entrez ID: 13706
|
Does Knockout of Rps21 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 81
|
Knockout
|
Rps21
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Rps21 (ribosomal protein S21)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cytoplasmic translation, endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA), translation; MF: ribosome binding, structural constituent of ribosome; CC: cytoplasm, cytosol, cytosolic ribosome, cytosolic small ribosomal subunit, endoplasmic reticulum, postsynapse, ribonucleoprotein complex, ribosome, rough endoplasmic reticulum, synapse
Pathways: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Cap-dependent Translation Initiation, Coronavirus disease - COVID-19 - Mus musculus (mouse), Eukaryotic Translation Initiation, Formation of a pool of free 40S subunits, Formation of the ternary complex, and subsequently, the 43S complex, GTP hydrolysis and joining of the 60S ribosomal subunit, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Metabolism of proteins, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Ribosomal scanning and start codon recognition, Ribosome - Mus musculus (mouse), Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Translation, Translation initiation complex formation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q9CQR2
Entrez ID: 66481
|
Does Knockout of Epha6 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,679
|
Knockout
|
Epha6
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Epha6 (Eph receptor A6)
Type: protein-coding
Summary: Predicted to enable transmembrane-ephrin receptor activity. Predicted to be involved in axon guidance and ephrin receptor signaling pathway. Predicted to be located in nucleoplasm. Predicted to be active in dendrite and plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; endometrium; male reproductive gland or organ; and sensory organ. Orthologous to human EPHA6 (EPH receptor A6). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: axon guidance, cell surface receptor protein tyrosine kinase signaling pathway, central nervous system development, ephrin receptor signaling pathway, regulation of developmental process; MF: ATP binding, GPI-linked ephrin receptor activity, ephrin receptor activity, kinase activity, nucleotide binding, protein kinase activity, protein tyrosine kinase activity, transferase activity, transmembrane receptor protein tyrosine kinase activity, transmembrane-ephrin receptor activity; CC: dendrite, membrane, plasma membrane
Pathways: Axon guidance - Mus musculus (mouse)
UniProt: G1K381
Entrez ID: 13840
|
Does Knockout of Zfp451 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,289
|
Knockout
|
Zfp451
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Zfp451 (zinc finger protein 451)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of transcription initiation by RNA polymerase II, negative regulation of transforming growth factor beta receptor signaling pathway, protein sumoylation; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, SUMO ligase activity, metal ion binding, sequence-specific DNA binding, transcription corepressor activity, transcription regulator inhibitor activity, transferase activity, zinc ion binding; CC: PML body, nucleoplasm, nucleus
Pathways:
UniProt: Q8C0P7
Entrez ID: 98403
|
Does Knockout of Polg2 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 2,477
|
Knockout
|
Polg2
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Polg2 (polymerase (DNA directed), gamma 2, accessory subunit)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA biosynthetic process, DNA repair, DNA replication, DNA-templated DNA replication, in utero embryonic development, mitochondrial DNA metabolic process, mitochondrial DNA replication, mitochondrion organization; MF: DNA binding, DNA polymerase binding, DNA polymerase processivity factor activity, DNA-directed DNA polymerase activity, double-stranded DNA binding, identical protein binding; CC: cytoplasm, gamma DNA polymerase complex, mitochondrial matrix, mitochondrial nucleoid, mitochondrion
Pathways: DNA Replication, Strand-asynchronous mitochondrial DNA replication
UniProt: Q9QZM2
Entrez ID: 50776
|
Does Knockout of Ccnd1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 82
|
Knockout
|
Ccnd1
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Ccnd1 (cyclin D1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, G1/S transition of mitotic cell cycle, Leydig cell differentiation, Wnt signaling pathway, animal organ regeneration, cell division, cell population proliferation, cellular response to hypoxia, endoplasmic reticulum unfolded protein response, fat cell differentiation, lactation, liver development, liver regeneration, mammary gland alveolus development, mammary gland epithelial cell proliferation, mitotic G1 DNA damage checkpoint signaling, negative regulation of epithelial cell differentiation, negative regulation of neuron apoptotic process, negative regulation of transcription by RNA polymerase II, neuron differentiation, positive regulation of G1/S transition of mitotic cell cycle, positive regulation of G2/M transition of mitotic cell cycle, positive regulation of cell population proliferation, positive regulation of mammary gland epithelial cell proliferation, re-entry into mitotic cell cycle, regulation of G1/S transition of mitotic cell cycle, regulation of cell cycle, response to UV-A, response to X-ray, response to calcium ion, response to corticosterone, response to estradiol, response to estrogen, response to ethanol, response to glucocorticoid, response to iron ion, response to leptin, response to magnesium ion, response to steroid hormone, response to vitamin E, response to xenobiotic stimulus; MF: cyclin-dependent protein serine/threonine kinase activator activity, cyclin-dependent protein serine/threonine kinase regulator activity, enzyme binding, histone deacetylase binding, kinase activity, proline-rich region binding, protein binding, protein kinase activity, protein kinase binding, protein serine/threonine kinase activator activity, protein-containing complex binding, transcription corepressor activity; CC: bicellular tight junction, cyclin D1-CDK4 complex, cyclin D1-CDK6 complex, cyclin-dependent protein kinase holoenzyme complex, cytoplasm, cytosol, membrane, microtubule organizing center, nuclear membrane, nucleoplasm, nucleus, transcription repressor complex
Pathways: AGE-RAGE signaling pathway in diabetic complications - Mus musculus (mouse), AMPK signaling pathway - Mus musculus (mouse), Acute myeloid leukemia - Mus musculus (mouse), Adaptive Immune System, Alcoholic liver disease - Mus musculus (mouse), Apelin signaling pathway - Mus musculus (mouse), Bladder cancer - Mus musculus (mouse), Breast cancer - Mus musculus (mouse), Cell Cycle, Cell Cycle, Mitotic, Cell cycle - Mus musculus (mouse), Cellular senescence - Mus musculus (mouse), Chemical carcinogenesis - receptor activation - Mus musculus (mouse), Chromatin modifying enzymes, Chromatin organization, Chronic myeloid leukemia - Mus musculus (mouse), Co-inhibition by PD-1, Colorectal cancer - Mus musculus (mouse), Cushing syndrome - Mus musculus (mouse), Cyclin A:Cdk2-associated events at S phase entry, Cyclin D associated events in G1, Cyclin E associated events during G1/S transition , Drug-mediated inhibition of CDK4/CDK6 activity, Endometrial cancer - Mus musculus (mouse), Epstein-Barr virus infection - Mus musculus (mouse), Focal adhesion - Mus musculus (mouse), FoxO signaling pathway - Mus musculus (mouse), G1 Phase, G1/S Transition, Gastric cancer - Mus musculus (mouse), Gene expression (Transcription), Generic Transcription Pathway, Glioma - Mus musculus (mouse), Hedgehog signaling pathway - Mus musculus (mouse), Hepatitis C - Mus musculus (mouse), Hepatocellular carcinoma - Mus musculus (mouse), Hippo signaling pathway - Mus musculus (mouse), Human T-cell leukemia virus 1 infection - Mus musculus (mouse), Human cytomegalovirus infection - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), Immune System, JAK-STAT signaling pathway - Mus musculus (mouse), Kaposi sarcoma-associated herpesvirus infection - Mus musculus (mouse), Measles - Mus musculus (mouse), Melanoma - Mus musculus (mouse), MicroRNAs in cancer - Mus musculus (mouse), Mitotic G1 phase and G1/S transition, Non-small cell lung cancer - Mus musculus (mouse), Oxytocin signaling pathway - Mus musculus (mouse), PI3K-Akt signaling pathway - Mus musculus (mouse), PTK6 Regulates Cell Cycle, Pancreatic cancer - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Prolactin signaling pathway - Mus musculus (mouse), Prostate cancer - Mus musculus (mouse), Proteoglycans in cancer - Mus musculus (mouse), RMTs methylate histone arginines, RNA Polymerase II Transcription, RUNX3 regulates p14-ARF, Regulation of PD-L1(CD274) Post-translational modification, Regulation of PD-L1(CD274) expression, Regulation of RUNX1 Expression and Activity, Regulation of T cell activation by CD28 family, S Phase, SCF(Skp2)-mediated degradation of p27/p21, SPOP-mediated proteasomal degradation of PD-L1(CD274), Signal Transduction, Signaling by Non-Receptor Tyrosine Kinases, Signaling by PTK6, Small cell lung cancer - Mus musculus (mouse), Thyroid cancer - Mus musculus (mouse), Thyroid hormone signaling pathway - Mus musculus (mouse), Tight junction - Mus musculus (mouse), Transcriptional regulation by RUNX1, Transcriptional regulation by RUNX2, Transcriptional regulation by RUNX3, Ubiquitin-dependent degradation of Cyclin D, Viral carcinogenesis - Mus musculus (mouse), Viral myocarditis - Mus musculus (mouse), Wnt signaling pathway - Mus musculus (mouse), p53 signaling pathway - Mus musculus (mouse)
UniProt: P25322
Entrez ID: 12443
|
Does Knockout of Fam135a in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 2,176
|
Knockout
|
Fam135a
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Fam135a (family with sequence similarity 135, member A)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways: RHO GTPase cycle, RND1 GTPase cycle, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q6NS59
Entrez ID: 68187
|
Does Knockout of Zfp113 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 81
|
Knockout
|
Zfp113
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Zfp113 (zinc finger protein 113)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, identical protein binding, metal ion binding, zinc ion binding; CC: nucleus
Pathways: Gene expression (Transcription), Generic Transcription Pathway, Herpes simplex virus 1 infection - Mus musculus (mouse), RNA Polymerase II Transcription
UniProt: Q5DTG4, Q8C689, D3Z3H8
Entrez ID: 56314
|
Does Knockout of Cmc2 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,152
|
Knockout
|
Cmc2
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Cmc2 (C-X9-C motif containing 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cytosol, mitochondrion
Pathways:
UniProt: Q8K199
Entrez ID: 66531
|
Does Knockout of Gm13283 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Gm13283
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Gm13283 (predicted gene 13283)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: B cell activation involved in immune response, T cell activation involved in immune response, adaptive immune response, defense response, defense response to virus, humoral immune response, natural killer cell activation involved in immune response, response to exogenous dsRNA, type I interferon-mediated signaling pathway; MF: cytokine activity, cytokine receptor binding, type I interferon receptor binding; CC: extracellular region, extracellular space
Pathways:
UniProt: A0A087WPG5
Entrez ID: 545645
|
Does Knockout of Srsf7 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 2,477
|
Knockout
|
Srsf7
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Srsf7 (serine and arginine-rich splicing factor 7)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Multiple protein-coding and non-protein-coding transcript variants have been found for this gene. [provided by RefSeq, Apr 2022].
Gene Ontology: BP: RNA splicing, cellular response to leukemia inhibitory factor, mRNA processing, mRNA transport, negative regulation of mRNA splicing, via spliceosome, regulation of alternative mRNA splicing, via spliceosome; MF: RNA binding, mRNA binding, metal ion binding, nucleic acid binding, protein binding, protein domain specific binding, zinc ion binding; CC: cytoplasm, nuclear speck, nucleoplasm, nucleus
Pathways: Amyotrophic lateral sclerosis - Mus musculus (mouse), Gene expression (Transcription), Herpes simplex virus 1 infection - Mus musculus (mouse), Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, RNA Polymerase II Transcription, RNA Polymerase II Transcription Termination, Spliceosome - Mus musculus (mouse), Transport of Mature Transcript to Cytoplasm, Transport of Mature mRNA derived from an Intron-Containing Transcript, mRNA 3'-end processing, mRNA Splicing, mRNA Splicing - Major Pathway, mRNA Splicing - Minor Pathway
UniProt: Q8BL97
Entrez ID: 225027
|
Does Knockout of Dtx1 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,280
|
Knockout
|
Dtx1
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Dtx1 (deltex 1, E3 ubiquitin ligase)
Type: protein-coding
Summary: Predicted to enable Notch binding activity; ubiquitin protein ligase activity; and ubiquitin protein ligase binding activity. Acts upstream of or within several processes, including Notch signaling pathway; cellular response to leukemia inhibitory factor; and negative regulation of T cell differentiation. Predicted to be located in cytosol and nuclear body. Predicted to be active in nucleoplasm. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; genitourinary system; and sensory organ. Orthologous to human DTX1 (deltex E3 ubiquitin ligase 1). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: Notch signaling pathway, cellular response to leukemia inhibitory factor, glial cell differentiation, negative regulation of T cell differentiation, negative regulation of neuron differentiation, protein ubiquitination, regulation of Notch signaling pathway; MF: Notch binding, SH3 domain binding, metal ion binding, protein binding, transferase activity, ubiquitin protein ligase activity, ubiquitin protein ligase binding, zinc ion binding; CC: cytoplasm, cytosol, nuclear body, nucleoplasm, nucleus
Pathways: Activated NOTCH1 Transmits Signal to the Nucleus, Notch signaling pathway - Mus musculus (mouse), Signal Transduction, Signaling by NOTCH, Signaling by NOTCH1
UniProt: Q61010
Entrez ID: 14357
|
Does Knockout of Noc3l in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 579
|
Knockout
|
Noc3l
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Noc3l (NOC3 like DNA replication regulator)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA replication initiation, fat cell differentiation; CC: mitochondrion, nuclear speck, nucleolus, nucleoplasm, nucleus
Pathways:
UniProt: Q8VI84
Entrez ID: 57753
|
Does Knockout of Kif14 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,267
|
Knockout
|
Kif14
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Kif14 (kinesin family member 14)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: SCF-dependent proteasomal ubiquitin-dependent protein catabolic process, activation of protein kinase activity, cell division, cell proliferation in forebrain, cerebellar Purkinje cell layer structural organization, cerebellar cortex development, cerebellar granular layer structural organization, cerebral cortex development, establishment of protein localization, hippocampus development, microtubule depolymerization, microtubule-based movement, mitotic metaphase chromosome alignment, negative regulation of apoptotic process, negative regulation of integrin activation, negative regulation of neuron apoptotic process, olfactory bulb development, positive regulation of cell population proliferation, positive regulation of cytokinesis, proteasome-mediated ubiquitin-dependent protein catabolic process, regulation of G1/S transition of mitotic cell cycle, regulation of G2/M transition of mitotic cell cycle, regulation of Rap protein signal transduction, regulation of cell adhesion, regulation of cell growth, regulation of cell maturation, regulation of cell migration, regulation of myelination, regulation of neuron apoptotic process, substrate adhesion-dependent cell spreading; MF: ATP binding, ATP hydrolysis activity, PDZ domain binding, microtubule binding, microtubule motor activity, nucleotide binding, plus-end-directed microtubule motor activity, protein kinase binding, tubulin binding; CC: Flemming body, cytoplasm, cytoskeleton, cytosol, kinesin complex, membrane, microtubule, midbody, nucleus, plasma membrane, spindle, spindle midzone
Pathways: RHO GTPase Effectors, RHO GTPase cycle, RHO GTPases activate CIT, RND1 GTPase cycle, RND2 GTPase cycle, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: L0N7N1
Entrez ID: 381293
|
Does Knockout of Tmc1 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,682
|
Knockout
|
Tmc1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Tmc1 (transmembrane channel-like gene family 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: auditory receptor cell development, calcium ion transmembrane transport, detection of mechanical stimulus involved in sensory perception of sound, monoatomic ion transmembrane transport, monoatomic ion transport, regulation of calcium ion transmembrane transport, sensory perception of sound, vestibular reflex; MF: calcium channel activity, mechanosensitive monoatomic ion channel activity, protein binding, voltage-gated calcium channel activity; CC: external side of plasma membrane, membrane, plasma membrane, stereocilium, stereocilium tip
Pathways:
UniProt: Q8R4P5
Entrez ID: 13409
|
Does Knockout of Myh9 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Myh9
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Myh9 (myosin, heavy polypeptide 9, non-muscle)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: actin cytoskeleton organization, actin filament bundle assembly, actin filament bundle distribution, actin filament capping, actin filament polymerization, actin filament-based movement, actomyosin structure organization, angiogenesis, blood vessel endothelial cell migration, cell adhesion, cell morphogenesis, cell motility, cell-cell adhesion, cortical granule exocytosis, cytokinetic process, cytoplasmic actin-based contraction involved in cell motility, cytoskeleton organization, endodermal cell differentiation, establishment of T cell polarity, establishment of meiotic spindle localization, follicle-stimulating hormone signaling pathway, in utero embryonic development, lysosome localization, meiotic spindle organization, membrane protein ectodomain proteolysis, monocyte differentiation, myoblast fusion, negative regulation of actin filament severing, negative regulation of vascular associated smooth muscle cell migration, phagocytosis, engulfment, phospholipase C-activating G protein-coupled receptor signaling pathway, plasma membrane repair, platelet formation, positive regulation of ERK1 and ERK2 cascade, positive regulation of G protein-coupled receptor signaling pathway, positive regulation of endocytosis, positive regulation of focal adhesion assembly, positive regulation of inositol trisphosphate biosynthetic process, positive regulation of insulin secretion involved in cellular response to glucose stimulus, positive regulation of phagocytosis, positive regulation of protein processing in phagocytic vesicle, protein transport, regulated exocytosis, regulation of actin filament organization, regulation of actin filament-based process, regulation of cell shape, regulation of plasma membrane repair, symbiont entry into host cell, uropod organization; MF: ADP binding, ATP binding, G-protein alpha-subunit binding, actin binding, actin filament binding, calmodulin binding, cytoskeletal motor activity, follicle-stimulating hormone receptor binding, identical protein binding, integrin binding, microfilament motor activity, nucleotide binding, protein binding, protein domain specific binding, protein homodimerization activity, protein kinase binding, protein-membrane adaptor activity, scaffold protein binding, virus receptor activity; CC: COP9 signalosome, Golgi apparatus, actin cytoskeleton, actin filament, actomyosin, actomyosin contractile ring, adherens junction, apical plasma membrane, brush border, cell cortex, cell leading edge, cell surface, cleavage furrow, cortical cytoskeleton, cortical granule, cytoplasm, cytoplasmic side of plasma membrane, cytoplasmic vesicle, cytoskeleton, cytosol, endosome, focal adhesion, immunological synapse, lamellipodium, lateral plasma membrane, myosin II complex, myosin II filament, myosin complex, myosin filament, neuromuscular junction, nuclear body, nucleus, phagocytic vesicle, plasma membrane, protein-containing complex, ruffle, spindle, stress fiber, uropod
Pathways: Fcgamma receptor (FCGR) dependent phagocytosis, Immune System, Innate Immune System, RHO GTPase Effectors, RHO GTPases activate PAKs, Regulation of actin cytoskeleton - Mus musculus (mouse), Regulation of actin dynamics for phagocytic cup formation, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Tight junction - Mus musculus (mouse), Vascular smooth muscle contraction - Mus musculus (mouse)
UniProt: Q8VDD5
Entrez ID: 17886
|
Does Knockout of Acsf3 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 2,477
|
Knockout
|
Acsf3
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Acsf3 (acyl-CoA synthetase family member 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: fatty acid biosynthetic process, fatty acid metabolic process, lipid metabolic process, malonate catabolic process; MF: ATP binding, CoA-ligase activity, ligase activity, malonyl-CoA synthetase activity, nucleotide binding, very long-chain fatty acid-CoA ligase activity; CC: mitochondrion
Pathways: Fatty acid biosynthesis - Mus musculus (mouse), Fatty acid metabolism, Fatty acyl-CoA biosynthesis, Metabolism, Metabolism of lipids, Synthesis of very long-chain fatty acyl-CoAs, Valine, leucine and isoleucine degradation - Mus musculus (mouse)
UniProt: Q3URE1
Entrez ID: 257633
|
Does Knockout of Gosr2 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,262
|
Knockout
|
Gosr2
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Gosr2 (golgi SNAP receptor complex member 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: intra-Golgi vesicle-mediated transport, protein transport, vesicle fusion, vesicle-mediated transport; MF: SNAP receptor activity, SNARE binding; CC: ER to Golgi transport vesicle membrane, Golgi apparatus, Golgi membrane, SNARE complex, cytoplasm, cytosol, endoplasmic reticulum, endoplasmic reticulum membrane, late endosome membrane, membrane, nucleoplasm
Pathways: Asparagine N-linked glycosylation, COPI-mediated anterograde transport, COPII-mediated vesicle transport, Cargo concentration in the ER, ER to Golgi Anterograde Transport, Intra-Golgi and retrograde Golgi-to-ER traffic, Intra-Golgi traffic, Membrane Trafficking, Metabolism of proteins, Post-translational protein modification, SNARE interactions in vesicular transport - Mus musculus (mouse), Transport to the Golgi and subsequent modification, Vesicle-mediated transport
UniProt: O35166
Entrez ID: 56494
|
Does Knockout of Armc7 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 1
| 1,265
|
Knockout
|
Armc7
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Armc7 (armadillo repeat containing 7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, biological_process, mRNA processing
Pathways:
UniProt: Q3UJZ3
Entrez ID: 276905
|
Does Knockout of Mob3b in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 1,130
|
Knockout
|
Mob3b
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Mob3b (MOB kinase activator 3B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: regulation of hippo signaling, signal transduction; MF: metal ion binding, protein kinase activator activity; CC: cytoplasm, nucleus
Pathways:
UniProt: Q8VE04
Entrez ID: 214944
|
Does Knockout of Jcad in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 81
|
Knockout
|
Jcad
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Jcad (junctional cadherin 5 associated)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell adhesion, positive regulation of MAPK cascade, positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis, positive regulation of cell migration involved in sprouting angiogenesis, positive regulation of sprouting angiogenesis, positive regulation of vascular endothelial growth factor signaling pathway; CC: adherens junction, anchoring junction, cell junction, cell-cell junction, perinuclear region of cytoplasm, ruffle membrane
Pathways:
UniProt: Q5DTX6
Entrez ID: 240185
|
Does Knockout of Rgl2 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,682
|
Knockout
|
Rgl2
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Rgl2 (ral guanine nucleotide dissociation stimulator-like 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of cardiac muscle cell apoptotic process, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, regulation of Ral protein signal transduction, signal transduction, small GTPase-mediated signal transduction; MF: guanyl-nucleotide exchange factor activity
Pathways: MAPK family signaling cascades, MAPK1/MAPK3 signaling, RAF/MAP kinase cascade, Ras signaling pathway - Mus musculus (mouse), Signal Transduction
UniProt: Q61193
Entrez ID: 19732
|
Does Knockout of Btn2a2 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,278
|
Knockout
|
Btn2a2
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Btn2a2 (butyrophilin, subfamily 2, member A2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: T cell receptor signaling pathway, negative regulation of ERK1 and ERK2 cascade, negative regulation of G1/S transition of mitotic cell cycle, negative regulation of T cell receptor signaling pathway, negative regulation of activated T cell proliferation, negative regulation of cytokine production, negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, positive regulation of regulatory T cell differentiation, regulation of cytokine production; CC: cell surface, external side of plasma membrane, membrane
Pathways: Adaptive Immune System, Butyrophilin (BTN) family interactions, Immune System
UniProt: A4QPC6
Entrez ID: 238555
|
Does Knockout of Lig4 in Lymphoma Cell Line causally result in response to chemicals?
| 1
| 1,558
|
Knockout
|
Lig4
|
response to chemicals
|
Lymphoma Cell Line
|
Gene: Lig4 (ligase IV, DNA, ATP-dependent)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DN2 thymocyte differentiation, DNA biosynthetic process, DNA damage response, DNA recombination, DNA repair, T cell receptor V(D)J recombination, V(D)J recombination, base-excision repair, cell division, cellular response to ionizing radiation, cellular response to lithium ion, central nervous system development, chromosome organization, double-strand break repair, double-strand break repair via classical nonhomologous end joining, double-strand break repair via nonhomologous end joining, fibroblast proliferation, immunoglobulin V(D)J recombination, in utero embryonic development, isotype switching, negative regulation of neuron apoptotic process, neuron apoptotic process, nucleotide-excision repair, DNA gap filling, positive regulation of chromosome organization, positive regulation of fibroblast proliferation, positive regulation of neurogenesis, pro-B cell differentiation, response to X-ray, response to gamma radiation, response to ionizing radiation, single strand break repair, somatic stem cell population maintenance, stem cell proliferation; MF: AMP binding, ATP binding, DNA binding, DNA ligase (ATP) activity, DNA ligase activity, ligase activity, magnesium ion binding, metal ion binding, nucleotide binding, protein binding; CC: DNA ligase IV complex, DNA-dependent protein kinase-DNA ligase 4 complex, condensed chromosome, nonhomologous end joining complex, nucleoplasm, nucleus
Pathways: DNA Double-Strand Break Repair, DNA Repair, Non-homologous end-joining - Mus musculus (mouse), Nonhomologous End-Joining (NHEJ)
UniProt: Q8BTF7
Entrez ID: 319583
|
Does Knockout of Prap1 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,280
|
Knockout
|
Prap1
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Prap1 (proline-rich acidic protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA damage response, signal transduction by p53 class mediator, cellular response to X-ray, deactivation of mitotic spindle assembly checkpoint, negative regulation of apoptotic process, positive regulation of intestinal lipid absorption, positive regulation of phospholipid transport, positive regulation of triglyceride transport; MF: lipid binding, protein binding, triglyceride binding; CC: endoplasmic reticulum, extracellular region
Pathways: Autophagy - animal - Mus musculus (mouse)
UniProt: Q80XD8
Entrez ID: 22264
|
Does Knockout of Clk2 in Regulatory T cell causally result in protein/peptide accumulation?
| 0
| 1,482
|
Knockout
|
Clk2
|
protein/peptide accumulation
|
Regulatory T cell
|
Gene: Clk2 (CDC-like kinase 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of gluconeogenesis, protein autophosphorylation, protein phosphorylation, regulation of RNA splicing, response to ionizing radiation, response to retinoic acid; MF: ATP binding, identical protein binding, kinase activity, nucleotide binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, protein serine/threonine/tyrosine kinase activity, protein tyrosine kinase activity, transferase activity; CC: nuclear body, nuclear speck, nucleoplasm, nucleus
Pathways:
UniProt: O35491
Entrez ID: 12748
|
Does Knockout of Fam178b in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,286
|
Knockout
|
Fam178b
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Fam178b (family with sequence similarity 178, member B)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q24JP3
Entrez ID: 381337
|
Does Knockout of E2f4 in Acute Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 684
|
Knockout
|
E2f4
|
cell proliferation
|
Acute Myeloid Leukemia Cell Line
|
Gene: E2f4 (E2F transcription factor 4)
Type: protein-coding
Summary: Enables DNA-binding transcription factor activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Acts upstream of or within several processes, including G1/S transition of mitotic cell cycle; cell volume homeostasis; and positive regulation of transcription by RNA polymerase II. Located in chromatin and nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Used to study otitis media. Human ortholog(s) of this gene implicated in Lynch syndrome. Orthologous to human E2F4 (E2F transcription factor 4). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: G1/S transition of mitotic cell cycle, animal organ morphogenesis, blood circulation, cell projection organization, cell volume homeostasis, centriole assembly, cilium assembly, epithelial cell development, motile cilium assembly, multi-ciliated epithelial cell differentiation, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of cell cycle, regulation of cell population proliferation, regulation of cell size, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription activator activity, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, chromatin binding, promoter-specific chromatin binding, protein binding, protein dimerization activity, protein domain specific binding, sequence-specific double-stranded DNA binding; CC: RNA polymerase II transcription regulator complex, chromatin, cytoplasm, nucleoplasm, nucleus, transcription regulator complex
Pathways: Cell Cycle, Cell Cycle, Mitotic, Cell cycle - Mus musculus (mouse), Cellular senescence - Mus musculus (mouse), Cyclin D associated events in G1, G0 and Early G1, G1 Phase, Gene expression (Transcription), Generic Transcription Pathway, Mitotic G1 phase and G1/S transition, RNA Polymerase II Transcription, SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription, Signal Transduction, Signaling by TGF-beta Receptor Complex, Signaling by TGFB family members, TGF-beta signaling pathway - Mus musculus (mouse), Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
UniProt: Q8R0K9
Entrez ID: 104394
|
Does Knockout of Top3a in Acute Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 684
|
Knockout
|
Top3a
|
cell proliferation
|
Acute Myeloid Leukemia Cell Line
|
Gene: Top3a (topoisomerase (DNA) III alpha)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA recombination, DNA repair, DNA topological change, chromosome separation, double-strand break repair via homologous recombination, mitochondrial DNA metabolic process, resolution of DNA recombination intermediates; MF: DNA binding, DNA topoisomerase activity, DNA topoisomerase type I (single strand cut, ATP-independent) activity, isomerase activity, metal ion binding, single-stranded DNA binding, zinc ion binding; CC: PML body, RecQ family helicase-topoisomerase III complex, chromosome, mitochondrial matrix, mitochondrion, nucleoplasm, nucleus
Pathways: Cell Cycle, Cell Cycle Checkpoints, DNA Double-Strand Break Repair, DNA Repair, Fanconi anemia pathway - Mus musculus (mouse), G2/M Checkpoints, G2/M DNA damage checkpoint, Gene expression (Transcription), Generic Transcription Pathway, HDR through Homologous Recombination (HRR), HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), HDR through Single Strand Annealing (SSA), Homologous DNA Pairing and Strand Exchange, Homologous recombination - Mus musculus (mouse), Homology Directed Repair, Presynaptic phase of homologous DNA pairing and strand exchange, Processing of DNA double-strand break ends, RNA Polymerase II Transcription, Regulation of TP53 Activity, Regulation of TP53 Activity through Phosphorylation, Resolution of D-Loop Structures, Resolution of D-loop Structures through Holliday Junction Intermediates, Transcriptional Regulation by TP53
UniProt: O70157
Entrez ID: 21975
|
Does Knockout of Trim44 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,679
|
Knockout
|
Trim44
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Trim44 (tripartite motif-containing 44)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: innate immune response, negative regulation of protein K48-linked ubiquitination, positive regulation of DNA-templated transcription, positive regulation of cytokine-mediated signaling pathway, positive regulation of defense response to virus by host, positive regulation of non-canonical NF-kappaB signal transduction, protein stabilization, regulation of gene expression; MF: metal ion binding, ubiquitin protein ligase activity, zinc ion binding; CC: cytoplasm
Pathways:
UniProt: Q9QXA7
Entrez ID: 80985
|
Does Knockout of Spink4 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 687
|
Knockout
|
Spink4
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Spink4 (serine peptidase inhibitor, Kazal type 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: peptidase inhibitor activity, serine-type endopeptidase inhibitor activity
Pathways:
UniProt: O35679
Entrez ID: 20731
|
Does Knockout of Pes1 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 1
| 2,307
|
Knockout
|
Pes1
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Pes1 (pescadillo ribosomal biogenesis factor 1)
Type: protein-coding
Summary: Predicted to enable RNA binding activity. Acts upstream of or within maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); nucleolus organization; and protein localization to organelle. Located in condensed chromosome and nucleolus. Part of PeBoW complex. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and respiratory system. Orthologous to human PES1 (pescadillo ribosomal biogenesis factor 1). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: fibroblast proliferation, maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), nucleolus organization, rRNA processing, regulation of cell cycle, ribosomal large subunit biogenesis, ribosome biogenesis; MF: RNA binding, protein binding, ribonucleoprotein complex binding; CC: PeBoW complex, chromosome, condensed chromosome, cytosol, nucleolus, nucleoplasm, nucleus, preribosome, large subunit precursor
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q9EQ61
Entrez ID: 64934
|
Does Knockout of Gas7 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 1,130
|
Knockout
|
Gas7
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Gas7 (growth arrest specific 7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: actin filament bundle assembly, actin filament polymerization, cell differentiation, clathrin coat assembly, clathrin-dependent endocytosis, nervous system development, neuron differentiation, neuron projection morphogenesis, regulation of cell shape; MF: actin filament binding, identical protein binding; CC: actin filament, clathrin-coated pit, clathrin-coated vesicle, cytoplasm, plasma membrane, ruffle
Pathways:
UniProt: B1ATI9, Q3U432, Q0VBR8, F6QB26, Q3U8N2, A0A6I8MWW1, A0A8I4T5Q7, A0A8I4SYY7
Entrez ID: 14457
|
Does Knockout of Dppa4 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 2,477
|
Knockout
|
Dppa4
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Dppa4 (developmental pluripotency associated 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: lung-associated mesenchyme development, system development; MF: chromatin binding; CC: nucleoplasm, nucleus
Pathways:
UniProt: Q8CCG4
Entrez ID: 73693
|
Does Knockout of Tcerg1l in Microglial Cell Line causally result in response to virus?
| 0
| 1,438
|
Knockout
|
Tcerg1l
|
response to virus
|
Microglial Cell Line
|
Gene: Tcerg1l (transcription elongation regulator 1-like)
Type: protein-coding
Summary: Predicted to enable RNA polymerase binding activity and transcription coregulator activity. Predicted to be active in nucleus. Is expressed in central nervous system and dorsal root ganglion. Orthologous to human TCERG1L (transcription elongation regulator 1 like). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: MF: RNA polymerase binding, transcription coregulator activity
Pathways:
UniProt: Q3B807
Entrez ID: 70571
|
Does Knockout of Steap1 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,684
|
Knockout
|
Steap1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Steap1 (six transmembrane epithelial antigen of the prostate 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: heme binding, metal ion binding; CC: endosome, endosome membrane, membrane, plasma membrane
Pathways: Mineral absorption - Mus musculus (mouse)
UniProt: Q9CWR7
Entrez ID: 70358
|
Does Knockout of Sod2 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,681
|
Knockout
|
Sod2
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Sod2 (superoxide dismutase 2, mitochondrial)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: acetylcholine-mediated vasodilation involved in regulation of systemic arterial blood pressure, apoptotic mitochondrial changes, cellular response to ethanol, cellular response to oxidative stress, detection of oxygen, erythrophore differentiation, glutathione metabolic process, heart development, hemopoiesis, hydrogen peroxide biosynthetic process, hydrogen peroxide metabolic process, intracellular oxygen homeostasis, intrinsic apoptotic signaling pathway in response to DNA damage, intrinsic apoptotic signaling pathway in response to oxidative stress, liver development, locomotory behavior, mitochondrion organization, multicellular organismal-level iron ion homeostasis, negative regulation of apoptotic process, negative regulation of cell population proliferation, negative regulation of fat cell differentiation, negative regulation of fibroblast proliferation, negative regulation of membrane hyperpolarization, negative regulation of neuron apoptotic process, negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway, negative regulation of vascular associated smooth muscle cell proliferation, neuron development, positive regulation of cell migration, positive regulation of hydrogen peroxide biosynthetic process, positive regulation of nitric oxide biosynthetic process, positive regulation of vascular associated smooth muscle cell apoptotic process, positive regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching, post-embryonic development, protein homotetramerization, regulation of blood pressure, regulation of mitochondrial membrane potential, regulation of transcription by RNA polymerase II, release of cytochrome c from mitochondria, removal of superoxide radicals, respiratory electron transport chain, response to L-ascorbic acid, response to activity, response to axon injury, response to cadmium ion, response to electrical stimulus, response to gamma radiation, response to hydrogen peroxide, response to hyperoxia, response to hypoxia, response to immobilization stress, response to isolation stress, response to lipopolysaccharide, response to magnetism, response to manganese ion, response to nutrient levels, response to oxidative stress, response to oxygen levels, response to reactive oxygen species, response to selenium ion, response to silicon dioxide, response to superoxide, response to xenobiotic stimulus, response to zinc ion, superoxide anion generation, superoxide metabolic process, vasodilation; MF: DNA binding, enzyme binding, identical protein binding, manganese ion binding, metal ion binding, oxidoreductase activity, oxygen binding, protein binding, superoxide dismutase activity; CC: cytoplasm, mitochondrial inner membrane, mitochondrial matrix, mitochondrial nucleoid, mitochondrion, myelin sheath
Pathways: Cellular response to chemical stress, Cellular responses to stimuli, Cellular responses to stress, Chemical carcinogenesis - reactive oxygen species - Mus musculus (mouse), Detoxification of Reactive Oxygen Species, FoxO signaling pathway - Mus musculus (mouse), Huntington disease - Mus musculus (mouse), Lipid and atherosclerosis - Mus musculus (mouse), Longevity regulating pathway - Mus musculus (mouse), Longevity regulating pathway - multiple species - Mus musculus (mouse), Mitochondrial biogenesis, Organelle biogenesis and maintenance, Peroxisome - Mus musculus (mouse), Transcriptional activation of mitochondrial biogenesis, superoxide radicals degradation
UniProt: P09671
Entrez ID: 20656
|
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